METTLER TOLEDO ME204 Advanced Analytical Balance with Internal Calibration (0.1 mg Readability)
| Brand | METTLER TOLEDO |
|---|---|
| Origin | Shanghai, China |
| Model | ME204 |
| Maximum Capacity | 220 g |
| Readability | 0.1 mg |
| Repeatability | 0.1 mg |
| Linearity | ±0.2 mg |
| Stabilization Time (typical) | 2 s |
| Sensitivity to Temperature Drift | 2.0 ppm/°C |
| Pan Diameter | Ø90 mm |
| Net Weight | 4.5–4.7 kg |
| Internal Calibration | Yes |
| Built-in Applications | 10 (e.g., formulation, counting, density, % weighing, checkweighing, statistics) |
Overview
The METTLER TOLEDO ME204 is a high-precision analytical balance engineered for routine laboratory applications requiring reliable 0.1 mg readability and long-term measurement stability. Designed within the NewClassic ME platform, it operates on electromagnetic force compensation (EMFC) principle — a proven technology ensuring high reproducibility, minimal drift, and immunity to mechanical wear. Its robust metal frame, reinforced housing, and overload protection up to 100 kg provide structural integrity under daily operational stress, making it suitable for QC labs, academic research environments, and regulated manufacturing settings where consistent traceable mass measurement is essential. The balance complies with international metrological standards including OIML R76 and EN 45501, and supports ISO/IEC 17025-compliant workflows through integrated GLP/GMP documentation features.
Key Features
- Internal calibration system activated via single-button operation, eliminating dependency on external weights and reducing operator error
- Ergonomic design with rounded edges, smooth surfaces, and front-access leveling feet for rapid setup and simplified cleaning
- High-speed stabilization (typically 2 seconds) enabled by advanced digital filtering and optimized damping algorithms
- Dual-range temperature compensation (2.0 ppm/°C sensitivity) ensures minimal drift across ambient fluctuations common in non-climate-controlled labs
- 10 pre-programmed application modes: formulation, parts counting, density determination, percentage weighing, checkweighing, statistical analysis, net/gross/tare operations, free-factor calculation, dynamic weighing, and summation
- GLP/GMP-ready functionality: automatic timestamping, user ID logging, and audit trail-compatible data output (via RS232 or optional USB interface)
- Sturdy cast-metal base and impact-resistant housing enhance durability in shared or high-traffic laboratory environments
Sample Compatibility & Compliance
The ME204 accommodates standard Ø90 mm weighing pans and is compatible with METTLER TOLEDO’s full range of draft shields (including manual and motorized variants) for volatile, hygroscopic, or static-prone samples. Its 220 g capacity and 0.1 mg resolution meet typical requirements for pharmaceutical active ingredient dispensing (per USP ), reference standard preparation, catalyst dosage in catalysis research, and gravimetric titration support. The balance satisfies key regulatory expectations: automatic internal calibration fulfills ASTM E898-22 recommendations for periodic verification; date/time stamping and user authentication align with FDA 21 CFR Part 11 data integrity principles when paired with compliant software; and its construction adheres to IEC 61010-1 safety standards for laboratory electrical equipment.
Software & Data Management
Data export is supported via RS232 serial interface (standard) or optional USB connection, enabling seamless integration with LIMS, ELN, or custom QA/QC databases. When used with METTLER TOLEDO’s LabX Lite (freely available), users gain basic report generation, customizable templates, and electronic signature capability for audit-ready records. All measurements include embedded metadata: timestamp, operator ID (if configured), balance ID, calibration status, and environmental condition flags (where external sensors are connected). Raw data files are generated in ASCII format for third-party statistical analysis tools, supporting Six Sigma initiatives and MSA (Measurement Systems Analysis) validation protocols.
Applications
The ME204 serves as a foundational instrument across multiple disciplines: in pharmaceutical development, it supports excipient blending verification and tablet weight uniformity testing per USP ; in materials science, it enables precise catalyst loading for heterogeneous reaction studies; in food testing labs, it performs moisture content determination via loss-on-drying protocols; in academic chemistry labs, it facilitates stoichiometric reagent preparation and gravimetric precipitate analysis. Its repeatability of 0.1 mg and linearity of ±0.2 mg ensure compliance with ISO 17025 clause 6.4.6 for measurement uncertainty estimation in accredited testing laboratories.
FAQ
Does the ME204 require external calibration weights?
No — it features a fully automated internal calibration mechanism triggered by a single front-panel button press.
Is the ME204 suitable for use in regulated GxP environments?
Yes, when operated with appropriate procedural controls and paired with compliant data capture software, it supports 21 CFR Part 11 and EU Annex 11 requirements.
What is the recommended environmental class for optimal performance?
Class III (moderate vibration, stable temperature ±2°C/hour, humidity 30–70% RH non-condensing) per ISO 4787.
Can the ME204 be connected to a networked lab information system?
Yes — via RS232-to-Ethernet converters or LabX central software for centralized monitoring and remote calibration management.
How often should internal calibration be performed?
Frequency depends on usage intensity and environmental stability; METTLER TOLEDO recommends initiation at startup, after relocation, following large temperature shifts (>2°C), and at defined intervals per your lab’s SOP (typically every 2–8 hours in continuous operation).
