Millipore D24 UV Ultra Pure Water System

Overview

The Millipore D24 UV Ultra Pure Water System is a fully integrated, high-performance laboratory water purification platform engineered for consistent production of Type I ultrapure water (per ASTM D1193-20 and ISO 3696:1987 Class 1) directly from municipal tap water. Leveraging Merck Millipore’s legacy in membrane science and ion exchange technology, the system combines a high-rejection reverse osmosis (RO) stage, dual-wavelength (185/254 nm) UV oxidation, nuclear-grade mixed-bed ion exchange resin (JetPore®), and terminal ultrafiltration to achieve stringent purity specifications required for sensitive analytical, molecular biology, and cell culture applications. Its temperature-compensated RO pump control ensures stable output across ambient feed water temperatures (5–40 °C), eliminating flow rate drift commonly observed in non-regulated systems. Designed and manufactured in Germany under ISO 9001:2015 quality management protocols, the D24 UV meets CE, CCC, and RoHS regulatory requirements and supports compliance with GLP, GMP, and FDA 21 CFR Part 11 when paired with audit-trail-enabled software modules.

Key Features

• Integrated dual-wavelength UV chamber (185 nm for TOC oxidation; 254 nm for microbial inactivation) positioned pre- and post-polishing stages
• High-capacity polishing cartridge containing 2000 g of proprietary JetPore® nuclear-grade ion exchange resin for extended service life and low leachables
• Temperature-negative-feedback RO pump system: automatically increases pressure by ~3% per °C drop to maintain constant 24 L/h pure water output between 3–40 °C
• Ultra-low dead-volume PVDF/PFA fluidic path with Parker-certified fittings and tubing to minimize extractables and biofilm risk
• High-precision resistivity sensor with 0.01 cm⁻¹ cell constant and ±0.1 °C thermal sensitivity; supports both temperature-compensated and USP-compliant non-compensated display modes
• Onboard wastewater recovery module achieving up to 50% feed water reuse, reducing operational cost and environmental footprint
• Remote dispensing arm with 360° rotation, real-time水质 display, audible/visual alarms, and compatibility with vessels from 250 mL beakers to 30 L carboys

Sample Compatibility & Compliance

The D24 UV delivers water meeting or exceeding international standards for critical laboratory use: ASTM Type I, ISO 3696 Class 1, CLSI EP28-A3c, and USP TOC limits. Terminal filtration options—including Millipak® Express 40 (0.22 µm sterilizing grade) and BioPak® ultrafilters (10 kDa MWCO)—enable application-specific configuration for endotoxin-free, nuclease-free, or particle-free water. All components are certified compliant with EU Medical Device Regulation (MDR 2017/745) Annex I essential requirements. Factory calibration includes traceable verification of resistivity, TOC, and endotoxin performance against NIST-traceable reference materials. System documentation includes QA test reports, metrological certification of sensors, and pyrogen challenge validation data per USP .

Software & Data Management

The intuitive touchscreen interface logs all operational parameters—including feed pressure, RO rejection rate, resistivity trends, UV lamp intensity, and cartridge usage hours—with automatic timestamping and user ID tagging. Historical data export is supported via USB or optional Ethernet connectivity (Modbus TCP/IP). When configured with Millipore’s LabManager™ software suite, the system enables full 21 CFR Part 11 compliance: electronic signatures, role-based access control, immutable audit trails, and automated report generation for QC/QA review. Calibration records, maintenance logs, and alarm histories are stored onboard for ≥12 months and can be printed directly from the display.

Applications

This system serves as the primary water source for high-sensitivity workflows including HPLC and UHPLC mobile phase preparation, ICP-MS and AAS standard dilution, ELISA and Western blotting reagent formulation, mammalian and stem cell culture media preparation, PCR/qPCR master mix assembly, and nanoparticle synthesis where trace metal or organic contamination compromises reproducibility. Its low endotoxin and nuclease levels support primary neuronal culture, organoid development, and CRISPR-Cas9 transfection protocols. The high-flow ultrapure output (2 L/min) also supports centralized distribution networks via optional 30–350 L stainless steel or PVDF storage tanks equipped with recirculation loops and additional 254 nm UV irradiation.

FAQ

What feed water quality is required for optimal D24 UV performance?
Municipal tap water with conductivity ≤ 2000 µS/cm at 25 °C, TOC ≤ 2000 ppb, free chlorine ≤ 3 ppb, SDI ≤ 12, pH 4–10, and pressure 1–6 bar.
Can the system be wall-mounted or installed under a bench?
Yes—optional wall-mount kits and under-cabinet brackets are available to optimize lab space utilization.
Is the resistivity sensor calibrated traceably to national standards?
Yes—each unit ships with a factory calibration certificate referencing NIST-traceable KCl solutions and verified per ISO/IEC 17025 accredited procedures.
How does the system handle low-temperature feed water conditions?
Its closed-loop temperature feedback algorithm dynamically adjusts RO pump pressure to maintain rated 24 L/h output across 5–40 °C ambient range without manual intervention.
What validation documentation is provided upon installation?
Includes Certificate of Conformance, Sensor Calibration Report, Endotoxin Challenge Test Summary, and ISO 9001:2015 QA Test Record—all signed and dated by authorized Merck Millipore Quality Assurance personnel.