NEXOPART ALPINE Sieve Discs (Original Haver & Boecker)
| Brand | NEXOPART |
|---|---|
| Origin | Germany |
| Manufacturer Type | Authorized Distributor |
| Origin Category | Imported |
| Model | ALPINE Sieve Disc |
| Pricing | Available Upon Request |
Overview
The NEXOPART ALPINE Sieve Discs are precision-engineered replacement sieve discs designed exclusively for integration with ALPINE e200LS series air jet sieving systems—including the e200LS, e200LS-N, and e200LS-AC models. These discs are manufactured to original Haver & Boecker specifications and meet stringent dimensional, material, and surface-finish tolerances required for reproducible particle size distribution (PSD) analysis under ISO 2591-1, ISO 9276-1, and ASTM E11 standards. Unlike conventional mechanical sieves, ALPINE air jet sieving relies on a high-frequency rotating nozzle generating a controlled radial airflow pattern within a sealed sieve chamber; the sieve disc serves as the critical interface between airflow dynamics and particle stratification. Its geometry—defined by precise aperture arrangement, thickness uniformity, and edge integrity—directly governs sieve efficiency, cut-point sharpness, and long-term calibration stability.
Key Features
- Exact dimensional and metallurgical match to original Haver & Boecker ALPINE e200LS OEM specifications, ensuring full mechanical and functional compatibility.
- Manufactured from high-grade stainless steel (AISI 316L or equivalent), providing corrosion resistance, non-reactivity with pharmaceutical and chemical powders, and compliance with USP particulate matter requirements.
- Laser-cut apertures with burr-free edges and consistent thickness (±0.02 mm tolerance) to minimize particle nesting and airflow turbulence during dynamic sieving.
- Traceable batch documentation supporting GMP/GLP environments, including material certification (EN 10204 3.1), surface roughness verification (Ra ≤ 0.8 µm), and aperture metrology reports.
- Available in standard ALPINE mesh sizes ranging from 20 µm to 3,150 µm (equivalent to 5–800 mesh per ASTM E11), with custom aperture configurations available upon technical review.
Sample Compatibility & Compliance
These sieve discs are validated for use with dry, free-flowing, non-agglomerating powders across industries including pharmaceuticals, fine chemicals, pigments, catalysts, and advanced ceramics. They support regulatory-compliant PSD testing per USP , EP 2.9.31, and ISO 13320 (laser diffraction correlation). When installed in an ALPINE e200LS system operated under documented SOPs—including vacuum calibration, time-controlled sieving cycles (typically 2–5 min), and post-sieve static charge dissipation—the discs contribute to measurement repeatability ≤2% RSD for D50 values across replicate runs. All discs comply with CE marking requirements for laboratory equipment and are compatible with IQ/OQ/PQ validation protocols under FDA 21 CFR Part 11–enabled ALPINE software environments.
Software & Data Management
While the sieve disc itself is a passive mechanical component, its performance is intrinsically linked to the ALPINE e200LS control firmware and data acquisition module. The system records real-time vacuum pressure, rotational speed, sieving duration, and residual mass per fraction—parameters that must remain stable across disc replacements to maintain method equivalence. NEXOPART provides disc-specific lot traceability files (PDF/CSV) for inclusion in electronic lab notebooks (ELN) and LIMS integration. For audit readiness, each disc batch includes a Certificate of Conformance referencing ISO/IEC 17025-accredited calibration evidence for aperture dimension verification using scanning electron microscopy (SEM) and optical profilometry.
Applications
- Quality control of active pharmaceutical ingredients (APIs) and excipients prior to tableting or capsule filling.
- Validation of milling and micronization processes in continuous manufacturing lines.
- Raw material release testing per ICH Q5A and Q5D guidelines for biologics and vaccine adjuvants.
- Particle engineering studies involving spray-dried dispersions, co-crystals, and lipid nanoparticles.
- Regulatory submission support—data generated using NEXOPART ALPINE Sieve Discs are accepted in ANDA, NDA, and MAA dossiers when used within fully validated e200LS workflows.
FAQ
Are these sieve discs certified for use in GMP-regulated environments?
Yes—each batch carries full traceability documentation aligned with Annex 11 and EU GMP Chapter 4 requirements, including material certificates and aperture verification reports.
Can they be autoclaved or cleaned with solvents?
Stainless steel construction permits cleaning with IPA, ethanol, or aqueous detergents; however, autoclaving is not recommended due to potential thermal distortion affecting aperture geometry.
What is the expected service life under routine QC usage?
With proper handling and avoidance of abrasive cleaning tools, typical operational lifespan exceeds 500 sieving cycles when used within specified pressure and feed-rate limits.
Do you offer mesh calibration verification services?
Yes—NEXOPART partners with ISO/IEC 17025-accredited metrology labs to provide optional third-party aperture certification upon request.
Is there a difference between “ALPINE e200LS” and “e200LS-N/AC” disc compatibility?
No—mechanical mounting dimensions and airflow interface geometry are identical across all e200LS variants; the same disc fits all models without modification.
