Zealpure Classic Ultra Pure Water System
| Origin | Shanghai, China |
|---|---|
| Manufacturer Type | Distributor |
| Origin Category | Domestic |
| Model | Zealpure Classic |
| Price | USD 2,800 (approx.) |
| Purified Water Grade | ASTM Type I / ISO 3696 Grade 1 |
| Resistivity | 18.2 MΩ·cm @ 25 °C |
| Heavy Metals & Soluble Silica | ≤0.1 ppb |
| Total Organic Carbon (TOC) | ≤3 ppb |
| Microbial Count | <0.001 CFU/mL |
| Endotoxin | <0.001 EU/mL |
| Particles (>0.1 µm) | <1 particle/mL |
Overview
The Zealpure Classic Ultra Pure Water System is an integrated, multi-stage laboratory water purification platform engineered to convert municipal tap water directly into Type I ultrapure water compliant with ASTM D1193-20, ISO 3696:1987, and CLSI EP22-A2 standards. It employs a sequential, synergistic purification architecture grounded in four core physical and chemical separation principles: reverse osmosis (RO), adsorptive carbon filtration, ion exchange (IX), and ultrafiltration (UF), augmented by dual-wavelength UV photooxidation (185 nm + 254 nm). This configuration ensures removal of >99.9% of dissolved ions, sub-ppb-level organic contaminants, endotoxins, nucleases, and particulates ≥0.1 µm—critical for applications demanding molecular-level purity, such as CRISPR-based genome editing workflows, primary cell line maintenance, and low-background trace metal analysis.
Key Features
- Integrated dual-output design: Simultaneously delivers RO-grade water (≥95% ion rejection) and Type I ultrapure water (18.2 MΩ·cm) from a single feed source—eliminating need for separate pre-treatment units.
- Ergonomic front-access architecture: Curved dispensing interface with extended vertical clearance enables unobstructed vessel placement; triple-side access panels facilitate rapid, tool-free replacement of RO membranes, UF cartridges, and mixed-bed ion exchange columns without system disassembly.
- Intelligent operational control: Fully automated startup sequence includes programmable RO membrane antiscalant flush (duration and frequency user-configurable); real-time resistivity/TOC monitoring with audible/visual alerts; auto-shutdown on reservoir fullness or inlet pressure loss.
- Validatable disinfection protocol: Closed-loop recirculation path supports tablet-based chemical sanitization (e.g., hydrogen peroxide or peracetic acid); all wetted surfaces constructed from USP Class VI-certified polypropylene and PTFE-lined stainless steel (316L).
- Endotoxin-specific ultrafiltration: 5 kDa molecular weight cutoff (MWCO) hollow-fiber UF module removes pyrogens to <0.001 EU/mL—validated per USP and EP 2.6.14—enabling safe use in embryology labs and monoclonal antibody production.
- TOC suppression system: Dual-lamp UV chamber (185 nm for hydroxyl radical generation; 254 nm for germicidal action) reduces non-volatile organics to ≤3 ppb, meeting stringent requirements for LC-MS mobile phase preparation and ICP-MS calibration.
Sample Compatibility & Compliance
The Zealpure Classic is compatible with standard municipal tap water supplies (chlorinated or chloraminated) meeting WHO Guidelines for Drinking-water Quality. All purification media are certified free of extractables per USP , and the final water output satisfies ISO 3696 Grade 1 specifications for resistivity, TOC, particles, and microbiological content. The system supports GLP/GMP-aligned operation through optional audit trail logging (via RS-232/USB interface), and its closed-loop design complies with FDA 21 CFR Part 11 requirements for electronic records when paired with validated LIMS integration. Documentation packages include IQ/OQ protocols and material compatibility certificates for all fluid-path components.
Software & Data Management
While the base model features embedded microcontroller-based monitoring (no external PC required), optional firmware upgrade enables Ethernet-enabled data export to laboratory information management systems (LIMS). Real-time parameters—including conductivity, TOC, UV absorbance at 254 nm, and cumulative runtime—are timestamped and stored onboard for ≥12 months. Export formats include CSV and XML, supporting traceability under ISO/IEC 17025 accreditation. Calibration logs, service history, and consumable life tracking are accessible via intuitive LCD menu navigation—no proprietary software installation needed.
Applications
- Life Sciences: Cell culture media preparation (including serum-free and feeder-free systems), transfection reagent formulation, qRT-PCR master mix dilution, ELISA plate coating buffers, and stem cell differentiation protocols requiring endotoxin-free water.
- Instrumental Analysis: Mobile phase preparation for UHPLC and nano-LC systems; blank matrix for ICP-MS multi-element calibration; rinse solutions for AA graphite furnace atomizers; carrier gas humidification in GC-MS headspace analysis.
- Quality Control & Regulatory Testing: USP TOC validation studies; EP 2.2.44 microbial enumeration controls; ASTM D512 chloride interference testing; and ISO 15195 reference material dilution in clinical diagnostics labs.
FAQ
What feed water quality is required for optimal RO membrane performance?
Municipal tap water with total dissolved solids (TDS) ≤500 ppm, free chlorine ≤1 ppm, and turbidity <1 NTU is recommended. Pre-filtration with 5 µm sediment and activated carbon cartridges is included in the standard configuration.
Can the system be validated for GMP environments?
Yes—IQ/OQ documentation templates, material traceability dossiers, and third-party calibration certificates for integrated sensors are available upon request. Optional 21 CFR Part 11-compliant electronic signature modules support audit-ready operation.
How often must consumables be replaced?
RO membranes: 12–24 months depending on feed water hardness; UF cartridges: 6–12 months; ion exchange resins: 6–18 months; UV lamps: 9,000 hours nominal lifetime (typically 12 months continuous use). System displays real-time usage counters for each component.
Is remote monitoring supported?
Standard models support local display and manual data export via USB. Remote telemetry and cloud-based alerting require the optional Ethernet communication module and ZealCloud™ gateway (sold separately).
Does the system meet ISO 14644-1 Class 5 cleanroom water requirements?
Yes—the integrated 0.1 µm final filter and laminar-flow dispensing arm minimize particle generation, and the closed distribution loop maintains particle counts below 1 particle/mL (>0.1 µm), satisfying ISO 14644-1 Class 5 airborne particulate limits for point-of-use delivery.
