membraPure Aquinity Integrated Pure & Ultrapure Water System
| Brand | membraPure |
|---|---|
| Origin | Germany |
| Manufacturer Type | Direct Manufacturer |
| Origin Category | Imported |
| Model | Aquinity |
| Pure Water Grade | ASTM Type I |
| Resistivity | 18.2 MΩ·cm |
| Heavy Metals & Soluble Silica | <0.1 ppb |
| Total Organic Carbon (TOC) | <5 ppb |
| Microbial Count | <0.1 CFU/mL |
| Endotoxins | <0.001 EU/mL |
| Particles (>0.1 µm) | <1 particle/mL |
| Flow Rate | 1.8 L/min |
| Production Capacity | 3 / 7 / 10 L/h |
| Recovery Rate | 35% |
Overview
The membraPure Aquinity Integrated Pure & Ultrapure Water System is an engineered solution for laboratories requiring dual-grade water production—simultaneous generation of ASTM Type I ultrapure water and ASTM Type III pure water—from a single, compact platform. Designed and manufactured in Germany, the system employs a multi-stage purification architecture grounded in reverse osmosis (RO), electrodeionization (EDI), ultrafiltration (UF), and dual-wavelength UV photo-oxidation (185/254 nm). This configuration ensures consistent removal of ionic contaminants, organic molecules, microorganisms, endotoxins, and sub-micron particulates—critical for applications demanding trace-level purity, including HPLC mobile phase preparation, ICP-MS calibration, cell culture media formulation, and molecular biology workflows such as PCR and sequencing.
Key Features
- Integrated dual-loop design: Independent purification pathways for pure water (RO + EDI) and ultrapure water (additional UF + 185/254 nm UV + final 0.1 µm filtration), minimizing cross-contamination risk.
- Real-time resistivity monitoring at point-of-use with temperature compensation (±0.1 °C), continuously verifying 18.2 MΩ·cm compliance per ASTM D1193 and ISO 3696.
- On-board TOC analyzer with catalytic UV oxidation and NDIR detection, delivering continuous <5 ppb TOC verification—essential for low-background analytical chemistry.
- Endotoxin-retentive ultrafiltration membrane (MWCO ≤ 10 kDa) validated to reduce endotoxin levels to <0.001 EU/mL, supporting sterile and pyrogen-free applications.
- Sanitizable stainless-steel (316L) distribution loop with integrated hot-water recirculation (80–85 °C) and automated sanitization cycles compliant with USP and EU GMP Annex 1 guidelines.
- Intuitive touchscreen HMI with configurable user access levels, event logging, and alarm history—fully audit-trail capable for GLP/GMP environments.
Sample Compatibility & Compliance
The Aquinity system is validated for compatibility with high-sensitivity instrumentation including HPLC, UHPLC, LC-MS, GC-MS, ICP-OES, and ICP-MS. Its output meets or exceeds international standards for laboratory water quality: ASTM Type I (D1193-20), ISO 3696:1987 Class 1, CLSI EP28-A3c, and USP Purified Water & Water for Injection (WFI) specifications where applicable. All wetted materials—including tubing, filters, and sensors—are USP Class VI-certified and extractables-tested per ISO 10993-12. The system supports full 21 CFR Part 11 compliance when paired with optional software modules enabling electronic signatures, role-based access control, and immutable audit trails.
Software & Data Management
The Aquinity Control Suite provides local and remote monitoring via Ethernet or Wi-Fi. It logs all critical parameters—including resistivity, TOC, pressure differentials, UV intensity, flow rate, and filter service intervals—with timestamped records stored for ≥12 months. Data export is supported in CSV and PDF formats; integration with LIMS is enabled through OPC UA and Modbus TCP protocols. Optional cloud-based fleet management allows centralized oversight of multiple units across distributed lab sites, with customizable alerting (email/SMS) for deviations from setpoint thresholds or maintenance milestones.
Applications
- HPLC/UHPLC mobile phase and blank preparation, ensuring baseline stability and minimal column fouling.
- ICP-MS and ICP-OES diluent preparation, where sub-ppt metal contamination must be avoided.
- Cell culture and stem cell expansion, leveraging low endotoxin and microbial content for reproducible viability assays.
- Next-generation sequencing library preparation and qPCR master mix formulation, where nucleic acid integrity depends on ultra-low nuclease and DNase activity.
- Cleaning of precision glassware and analytical components, using dedicated pure water loop to prevent residue buildup without compromising ultrapure loop integrity.
FAQ
What is the maximum allowable feed water conductivity for optimal Aquinity performance?
Feed water conductivity should not exceed 500 µS/cm (TDS ≤ 300 ppm); higher values require pretreatment evaluation.
Can the system be configured for continuous 24/7 operation in a core facility?
Yes—the Aquinity is rated for uninterrupted duty cycle with redundant pump control, automatic leak detection, and fail-safe shut-down logic.
Is validation documentation provided for IQ/OQ/PQ protocols?
Full factory-verified IQ/OQ documentation is included; PQ support packages with third-party certified test protocols are available upon request.
How often must consumables be replaced under typical lab usage (10 L/h, 8 h/day)?
Pre-filters: 6 months | RO membrane: 24–36 months | EDI stack: 36–48 months | UF cartridge: 12 months | Final 0.1 µm filter: 3–6 months.
Does the system support external dispensing arms or wall-mounted manifolds?
Yes—modular outlet configurations include single-point faucets, multi-port dispensing stations, and sterile-grade air-gap manifolds compatible with ISO Class 5 laminar flow hoods.
