Agilent 7890A-7000B Used GC-MS System

Overview

The Agilent 7890A-7000B is a pre-owned, fully refurbished triple quadrupole gas chromatography–mass spectrometry (GC-MS/MS) system engineered for high-sensitivity, quantitative trace analysis in regulated and research laboratories. This configuration integrates the Agilent 7890A gas chromatograph—featuring advanced electronic pressure control (EPC), split/splitless injection, and oven temperature programming up to 450 °C—with the 7000B triple quadrupole mass spectrometer, which delivers selective reaction monitoring (SRM) capability with unit-mass resolution, low-picoamp detection limits, and robust ion optics optimized for routine environmental, food safety, and pharmaceutical residue testing. The system operates on electron ionization (EI) and optional chemical ionization (CI) modes, supporting both targeted quantitation and confirmatory identification per ICH M7 and USP guidelines.

Key Features

• Refurbished and functionally verified GC-MS/MS platform meeting Agilent’s second-life instrument performance specifications
• 7890A GC module with dual independent EPC channels, 120-position autosampler compatibility, and inert flow path for reduced adsorption of polar analytes
• 7000B MS module with triple quadrupole architecture enabling >10,000 SRM transitions per run, collision cell with nitrogen or argon gas, and dynamic dwell time optimization
• Mass range: 10–1050 m/z; scan speed up to 12,000 Da/sec in full-scan mode; SRM dwell times adjustable from 1 ms to 1000 ms
• Integrated vacuum system with turbomolecular pump (70 L/s) and backing pump; base pressure <5 × 10⁻⁶ Torr achieved within 30 minutes post-pump-down
• Compliant with FDA 21 CFR Part 11 requirements when deployed with MassHunter software vB.08.03 or higher and appropriate audit-trail configuration

Sample Compatibility & Compliance

This GC-MS/MS system supports volatile and semi-volatile organic compounds (VOCs/SVOCs) across matrices including water, soil extracts, biological fluids, food homogenates, and polymer leachates. It accommodates standard 2 mL autosampler vials and is compatible with common derivatization protocols (e.g., silylation, acylation). All refurbished units undergo comprehensive calibration verification using NIST-traceable standards (e.g., perfluorotributylamine, chlorobenzene), retention time locking (RTL), and tune report validation per Agilent G1701EA Rev. E specifications. The system satisfies analytical method requirements outlined in EPA Methods 8270D (SVOCs), 8260D (VOCs), 1613B (PCBs), and EU Commission Regulation (EU) No 2021/2008 for pesticide residue analysis.

Software & Data Management

Controlled via Agilent MassHunter Workstation (Quantitative and Qualitative Analysis editions), the system supports secure user authentication, electronic signatures, and full audit-trail logging—including method changes, data reprocessing events, and instrument parameter adjustments. Raw data files (.d format) are stored with embedded metadata (acquisition time, operator ID, instrument serial number) and support long-term archival in accordance with ISO/IEC 17025:2017 Clause 7.5.3. Optional integration with Agilent OpenLab CDS enables centralized instrument scheduling, raw data backup, and LIMS interfacing via ASTM E1467-compliant drivers.

Applications

• Environmental testing: Quantification of PAHs, PCBs, organochlorine pesticides, dioxins/furans in wastewater, sediment, and air particulate matter
• Food safety: Multi-residue screening of >400 pesticides in fruits, vegetables, and infant formula per SANTE/11813/2017 guidelines
• Pharmaceutical impurity profiling: Detection and quantitation of genotoxic impurities (GTIs) at ≤1 ppm levels in drug substances
• Forensic toxicology: Confirmation of controlled substances (e.g., cannabinoids, opioids) in urine and blood specimens per SWGTOX recommendations
• Materials science: Identification of extractables and leachables from medical device packaging under ISO 10993-18

FAQ

What calibration and verification documentation is provided with the instrument?
Each unit ships with a Certificate of Refurbishment, full tune report, retention time lock verification, and calibration verification using NIST-traceable standards. A complete set of as-found/as-left test records is included.
Is the system compatible with current MassHunter software versions?
Yes—the 7000B firmware supports MassHunter vB.08.03 through vB.10.x. Software licensing is transferable upon Agilent’s standard second-user agreement.
Can this system be qualified for GxP environments?
Yes. IQ/OQ protocols aligned with ASTM E2500 and Annex 11 are available; PQ execution requires site-specific matrix validation. Full 21 CFR Part 11 compliance is achievable with proper configuration and administrative controls.
What consumables and spare parts are included?
Standard shipment includes one GC column (30 m × 0.25 mm × 0.25 µm DB-5ms), source cleaning kit, tuning compound vial, and six months of technical support.
How is instrument performance validated prior to delivery?
All systems undergo 72-hour continuous operation testing, sensitivity verification (1 pg OFN @ S/N ≥ 500:1 in SIM mode), peak shape assessment (asymmetry factor <1.3), and carryover evaluation (<0.1%) using certified reference materials.