Masterflex L/S Digital Programmable Split-Drive Peristaltic Pump Model 77301-20
| Brand | Cole-Parmer |
|---|---|
| Origin | USA |
| Manufacturer Type | Authorized Distributor |
| Product Category | Imported Laboratory Equipment |
| Models | 77301-20, 77923-60, 77923-70 |
| Flow Rate Range | 0.006–3400 mL/min |
| Speed Range | 10–600 rpm |
| Speed Accuracy | ±0.3% |
| Flow Control Accuracy | ±0.5% |
| Volume Dispensing Range | 1 mL–999 L |
| Repetition Count | 1–99 cycles |
| Interval Time Between Cycles | 1–9999 s |
| Input/Output Signals | 0–20 mA, 4–20 mA, 0–10 V, TTL pulse |
| Motor Protection Rating | IP56 |
| Controller Protection Rating (77301-20) | IP22 |
| Power Supply | 90–260 V AC, 75 W, 1/10 HP |
| Dimensions (Controller) | 24.8 × 23.3 × 12.9 cm |
| Dimensions (Drive Unit) | 26.7 × 9.7 × 11.7 cm |
| Max. Tube ID × OD × Wall Thickness Supported | 9.6 × 14.4 × 2.4 mm |
| Compatible Tubing Standards | L/S® series (e.g., #13–#36), Tygon® LFL, Platinum-Cured Silicone, PTFE-lined |
| Certifications | UL, CE, ISO 9001:2000 |
Overview
The Masterflex L/S Digital Programmable Split-Drive Peristaltic Pump Model 77301-20 is an industrial-grade, precision fluid handling system engineered for reproducible volumetric delivery in analytical, bioprocessing, and quality control laboratories. Based on the well-established peristaltic pumping principle—where a rotating roller compresses flexible tubing to generate positive displacement—the 77301-20 delivers contamination-free, pulseless flow without valves or seals. Its split-drive architecture physically separates the motor-driven pump head from the digital controller, enabling remote placement of the drive unit in harsh or space-constrained environments while maintaining full operational oversight at the control panel. The system employs brushless DC motors with precision PWM speed regulation, ensuring long-term stability, zero maintenance, and bidirectional operation essential for pre- and post-pumping tube rinse protocols.
Key Features
- Dual-mode digital interface with four-digit LED display showing real-time values for flow rate, rotational speed, elapsed time, dispensed volume, and cycle count
- Intuitive touch-key navigation for parameter adjustment—up/down keys for incremental changes; dedicated forward/reverse toggle for directional control
- Keyboard lock function prevents accidental setting modification during unattended operation
- Remote analog and digital I/O support (0–20 mA, 4–20 mA, 0–10 V, TTL pulse) enables integration into PLC-controlled or SCADA-based process automation systems
- IP56-rated drive unit withstands washdown conditions, dust ingress, and incidental splashing—suitable for ISO Class 8 cleanrooms and manufacturing floor deployment
- IP22-rated controller provides basic environmental protection for benchtop use; optional 77301-30 variant offers full IP56 rating on both controller and drive
- Motor-controller cable length: 7.6 m standard, with extended cabling options available for distributed system layouts
- Two-pump-head capability supports parallel operation for increased throughput or dual-stream applications such as reagent mixing or sequential dosing
- Onboard calibration memory stores one set of flow-rate vs. tubing size profiles—enabling rapid switching between L/S® tube sizes (#13 through #36) without recalibration
Sample Compatibility & Compliance
The 77301-20 accommodates a wide range of chemically resistant tubing materials—including Tygon® LFL, platinum-cured silicone (standard and enhanced bio-grade), and PTFE-lined or PTFE-diaphragm pump heads—ensuring compatibility with aggressive solvents, high-pH buffers, cell culture media, and viscous biologics. It supports L/S®-standard tubing dimensions up to 9.6 mm inner diameter, delivering flow rates from 0.6 mL/min (with #13 tubing) to 3400 mL/min (with #36 high-pressure tubing). All configurations comply with UL 61010-1 and CE marking requirements for laboratory electrical safety. The system meets ISO 9001:2000 quality management standards and is routinely validated under GLP and GMP frameworks where traceability, repeatability, and audit-ready documentation are required. While not inherently 21 CFR Part 11 compliant, its analog/digital I/O interface allows seamless integration with validated software platforms that provide electronic signatures, audit trails, and user access controls.
Software & Data Management
As a hardware-only platform, the 77301-20 does not include embedded software but is fully compatible with third-party data acquisition and process control systems via its standardized analog and TTL interfaces. Users may log flow parameters, cycle events, and alarm states using LabVIEW, MATLAB, or custom SCADA implementations. For standalone operation, all critical settings—including target volume, repetition count, interval timing, and direction—are retained in non-volatile memory after power loss. Optional accessories such as footswitches (07595-42/43) and handheld remotes (07595-60/83) extend operator flexibility in glove-box or biosafety cabinet environments. Remote control cable extensions (e.g., 77300-32, 8.3 m) facilitate installation in ventilated enclosures or behind fume hoods.
Applications
This pump serves critical roles across pharmaceutical development (buffer preparation, column equilibration, fraction collection), clinical diagnostics (sample dilution, reagent dispensing), food & beverage QA (viscosity-adjusted syrup transfer), and environmental testing (continuous wastewater sampling). Its bidirectional capability supports automated cleaning-in-place (CIP) sequences, while high-resolution volumetric dispensing (down to 20 µL with #13 tubing) meets USP requirements for low-volume assay preparation. Multi-pump-head configurations enable simultaneous delivery of multiple reagents into microplate readers or parallel bioreactor feeds. When paired with Easy-Load II pump heads and Tygon LFL tubing, it achieves >1000 hours of continuous operation in sterile liquid transfer applications.
FAQ
What tubing sizes are supported by the 77301-20?
It accepts all L/S®-standard tubing, including #13 (0.8 mm ID), #14 (1.6 mm ID), #16 (3.2 mm ID), #17–#18 (6.4–8.0 mm ID), and high-pressure variants #15, #24, #35, and #36 (up to 9.6 mm ID).
Can the pump be integrated into a validated production environment?
Yes—its analog I/O signals and deterministic mechanical behavior support qualification per IQ/OQ/PQ protocols. Calibration records, maintenance logs, and operational history must be maintained externally per GMP Annex 11.
Is firmware upgrade capability available?
No—the 77301-20 uses fixed-function digital logic; no field-upgradable firmware is provided. Parameter retention and signal integrity are ensured through hardware-level design.
What is the maximum allowable backpressure for continuous operation?
With #36 tubing and a high-pressure pump head, the system sustains up to 10.2 bar (148 psi); performance degrades linearly above this threshold depending on tubing elasticity and temperature.
How is accuracy verified during routine qualification?
Accuracy is confirmed using gravimetric measurement per ASTM D1298 or ISO 4787, comparing dispensed mass against theoretical volume based on calibrated tubing dimensions and rotational speed.
