Masterflex L/S Programmable Computer-Compatible Peristaltic Pump System Model 77924-50

Overview

The Masterflex L/S Programmable Peristaltic Pump System (Model 77924-50) is a precision-engineered, computer-compatible fluid handling platform designed for demanding laboratory, pilot-scale, and regulated manufacturing environments. Based on the proven L/S-series architecture from Masterflex (a Cole-Parmer brand), this system employs positive displacement peristaltic pumping—where rollers compress flexible tubing against a curved housing to generate flow—ensuring complete fluid isolation, zero contamination risk, and repeatable volumetric delivery without valves or seals. Its brushless DC motor delivers exceptional speed stability (±0.1% accuracy across the full 0.1–600 rpm range), enabling precise control over low-flow microdispensing (down to 0.001 mL/min) and high-throughput transfer (up to 3400 mL/min with 36# tubing and high-pressure head). The system’s modular design supports single- or dual-pump-head configurations and integrates seamlessly into automated workflows via analog, digital, and serial interfaces—making it suitable for GLP/GMP-compliant processes where traceability, repeatability, and regulatory alignment are non-negotiable.

Key Features

• Graphical LCD interface with intuitive multilingual menu (including Chinese), configurable keypad lock, and real-time display of operational parameters (speed, volume dispensed, elapsed time, mode status)
• Digital PWM motor control ensures stable, low-noise operation and eliminates mechanical wear associated with brushed motors
• Bidirectional rotation enables pre- and post-pump tube flushing, backflushing of viscous or particulate-laden fluids, and bidirectional process sequencing
• Four programmable dispensing modes: continuous run, timed dispense, repeat dispense (with adjustable interval and cycle count), and volume-based dispense (target volume from 0.001 to 9999 mL)
• Integrated analog I/O (0–20 mA, 4–20 mA, 0–10 V) and TTL-level remote control signals support integration with PLCs, balances, pH meters, and environmental controllers
• Dual-pump-head capability (via 07551-00 driver) allows synchronized or independent control of two flow paths using identical or disparate tubing sizes
• IP33-rated enclosure provides protection against vertically falling water droplets and solid objects >2.5 mm—suitable for standard laboratory benchtop use
• Compliance-ready firmware with password-protected user roles, timestamped audit trails, and encrypted log files meeting FDA 21 CFR Part 11 requirements for electronic records and signatures

Sample Compatibility & Compliance

The 77924-50 system accommodates a broad spectrum of chemically aggressive, sterile, shear-sensitive, and high-viscosity fluids through its extensive L/S tubing portfolio—including platinum-cured silicone (biocompatible, USP Class VI), Tygon® LFL (low extractables, long service life), PTFE-lined, and PTFE-diaphragm pump heads. Tubing selection directly governs pressure rating, chemical resistance, and flow linearity; for instance, 15#, 24#, 35#, and 36# thick-wall tubing (2.4 mm wall thickness) support higher suction lift and elevated discharge pressures (up to 10.2 bar with optional high-pressure head). All configurations maintain fluid path integrity without wetted metal parts, eliminating corrosion, leaching, or cross-contamination risks. The system conforms to ETL and CE safety standards, carries ISO 9001:2000 quality management certification, and supports validation documentation packages required for pharmaceutical, biotech, and food-grade applications under cGMP, ISO 13485, and ASTM D4169 protocols.

Software & Data Management

Masterflex FlowPro™ software transforms the 77924-50 into a networked fluid automation node. Installed on Windows-based host PCs, FlowPro enables centralized control of up to 25 pumps via RS-232 or USB-to-serial adapters. Each pump can be individually configured for flow unit (mL/min or L/min), tubing ID/OD/wall dimensions (to auto-limit flow range and enhance volumetric accuracy), and multi-stage timed or volume-triggered sequences—up to 50 discrete steps per program. Critical features include real-time data logging (flow rate, direction, start/stop events), external device synchronization (e.g., balance-triggered stop, stirrer speed coupling), and automated report generation. All user actions—including parameter changes, program uploads, and emergency stops—are captured in tamper-evident, encrypted audit logs with user ID, timestamp, and action description—fully satisfying FDA 21 CFR Part 11 requirements for electronic record retention, role-based access control, and electronic signature enforcement.

Applications

This system serves as a foundational fluid transfer solution across diverse technical domains. In analytical chemistry labs, it delivers precise reagent metering for titrators, autosamplers, and ICP-MS sample introduction systems. In bioprocessing, it handles cell culture media, buffers, and harvest streams under aseptic conditions—especially when paired with USP Class VI platinum-cured tubing and gamma-sterilizable pump heads. For formulation development, the repeat dispense and volume-based modes enable accurate multi-component blending into vessels (e.g., 100×20 L batches with eight ingredient streams), with weight feedback from calibrated balances triggering step transitions. Environmental testing labs use it for continuous eluent delivery in ion chromatography or automated leachate sampling. Additionally, its analog I/O compatibility makes it ideal for closed-loop pH or conductivity control in fermentation reactors and wastewater treatment simulators.

FAQ

What tubing sizes are supported by the 77924-50 system, and how do they affect flow performance?
The system supports L/S-series tubing ranging from #13 (0.8 mm ID) to #36 (9.6 mm ID), with wall thicknesses of 1.6 mm or 2.4 mm. Smaller IDs yield finer resolution at low flow rates; larger IDs with 2.4 mm walls (e.g., #35, #36) deliver higher flow capacity and pressure tolerance—up to 3400 mL/min with the high-pressure pump head.
Can the pump operate without a computer connection?
Yes—the front-panel LCD and keypad allow fully autonomous operation in all four dispensing modes. Computer connectivity is optional and used only for advanced programming, multi-pump coordination, or regulatory-compliant data capture.
Is calibration required for different fluids, and how is it managed?
Because flow rate depends on fluid density, viscosity, and tubing elasticity, users perform one-time volumetric calibration per tubing size and fluid type. The pump stores one calibration curve per tubing ID, enabling correction factors to be applied in real time during volume-based dispensing.
Does the system support integration with laboratory information management systems (LIMS)?
While not natively LIMS-integrated, FlowPro™ exports CSV-formatted logs and supports OPC UA-compatible industrial gateways. Custom API scripting (via serial command set) enables bidirectional communication with third-party LIMS platforms for sample tracking and result association.
What safety certifications apply to the 77924-50 driver unit?
The driver is ETL Listed to UL 61010-1 (Laboratory Equipment Safety) and CE-marked per the Low Voltage Directive (2014/35/EU) and EMC Directive (2014/30/EU), ensuring safe operation in global laboratory environments.