MakeWave MKX-E1G6A Microwave-Assisted Extraction System
| Brand | MakeWave |
|---|---|
| Origin | Shandong, China |
| Manufacturer Type | Original Equipment Manufacturer (OEM) |
| Country of Origin | China |
| Model | MKX-E1G6A |
| Microwave Output Power | 800 W (continuous, non-pulsed) |
| Microwave Frequency | 2450 MHz |
| Temperature Control Range | 0–220 °C |
| Temperature Accuracy | ±1% of setpoint |
| Cavity Material | Seamless 304 stainless steel with multi-layer PTFE coating |
| Cavity Volume | ~20 L |
| Maximum Operating Pressure | 3 MPa |
| Sample Capacity | 6 × 80 mL parallel high-pressure extraction vessels |
| Power Supply | 220 V AC, 50 Hz |
| Total Power Consumption | 1300 W |
| Dimensions (W×H×D) | 782 × 492 × 450 mm |
| Weight | 65 kg |
| Safety Compliance | Microwave leakage < 5 mW/cm² (exceeding GB 10436-2008), ISO 9001 certified |
Overview
The MakeWave MKX-E1G6A Microwave-Assisted Extraction System is an engineered platform for controlled, reproducible, and scalable microwave-enhanced solid-liquid extraction. It operates on the principle of dielectric heating—where polar solvents and target analytes absorb microwave energy at 2450 MHz, inducing rapid and uniform internal heating within sealed reaction vessels. Unlike conventional conductive heating methods, this volumetric energy transfer accelerates mass transfer kinetics, reduces solvent consumption, and improves extraction efficiency for thermolabile and recalcitrant compounds. Designed for compliance-driven laboratories, the MKX-E1G6A supports method development and routine analysis in regulated environments—including those adhering to ASTM D7676 (microwave-assisted extraction of organic compounds from soils), USP <2021> (microwave digestion/extraction), and EPA Method 3546. Its 20 L monolithic cavity, rated for continuous 800 W output and sustained operation up to 220 °C and 3 MPa, provides a stable thermal-mechanical environment for validated protocols.
Key Features
- Seamless 304 stainless steel cavity with multi-layer PTFE interior coating—resistant to aggressive acids, bases, and oxidants; facilitates cleaning and extends service life under repeated high-temperature cycling.
- 6-position parallel processing system with 80 mL PTFE-lined high-pressure extraction vessels—each equipped with integrated fiber-optic temperature sensing and pressure transduction for real-time, vessel-level monitoring.
- Non-pulsed, continuously variable microwave power delivery (0–800 W) enables precise energy dosing—critical for optimizing extraction selectivity and minimizing thermal degradation.
- PLC-based control architecture with 7-inch capacitive touchscreen interface—supports programmable ramp-hold-cool profiles, automatic data logging (time, temperature, pressure, power), and export to CSV format for LIMS integration.
- Dual-safety interlock system: mechanical door latch with λ/4 choke structure suppresses microwave leakage (<5 mW/cm²), while negative-pressure exhaust actively evacuates volatile byproducts during and after extraction cycles.
- Optional real-time video monitoring module—mounted via borosilicate observation window—enables visual confirmation of sample homogeneity, boiling behavior, and vessel integrity without interrupting operation.
Sample Compatibility & Compliance
The MKX-E1G6A accommodates diverse sample matrices including plant biomass (e.g., essential oil precursors), pharmaceutical botanicals, environmental solids (soils, sediments, airborne particulates), and polymer-embedded residues. Its 80 mL vessel configuration is optimized for EPA-compliant extractions using low-dielectric solvents (e.g., hexane, dichloromethane) when paired with optional dielectric enhancers. All wetted components comply with USP Class VI biocompatibility requirements. The system meets ISO 9001:2015 quality management standards and conforms to electromagnetic compatibility (EMC) directives per IEC 61000-6-3 and safety requirements per IEC 61010-1. For GLP/GMP applications, audit trails, user access levels, and electronic signature support can be implemented via firmware extension.
Software & Data Management
The embedded control software records timestamped process variables at 1-second intervals and stores up to 100 complete extraction protocols locally. Data export is compatible with standard laboratory informatics systems—CSV files include calibrated temperature (via embedded fiber-optic sensor), absolute pressure (piezoresistive transducer), and delivered microwave power (RF power meter feedback loop). Optional Ethernet or RS-485 interfaces enable remote supervision and integration into centralized lab automation frameworks. Full traceability is maintained through session logs that record operator ID, start/stop times, parameter deviations, and alarm events—supporting FDA 21 CFR Part 11 readiness when deployed with validated authentication modules.
Applications
- Essential oil isolation from citrus peels, lavender, and eucalyptus via accelerated solvent extraction (ASE) with ethanol/water mixtures.
- Quantitative recovery of active pharmaceutical ingredients (APIs) and marker compounds (e.g., curcumin, hypericin) from herbal matrices under USP-referenced conditions.
- Multi-residue pesticide analysis in agricultural soils per EN 15662:2018—using acetonitrile-based QuEChERS-compatible workflows.
- Extraction of polycyclic aromatic hydrocarbons (PAHs) and phthalate esters from atmospheric PM₂.₅ filters prior to GC-MS analysis.
- Development of green chemistry protocols—reducing solvent volume by >60% and cycle time by >75% compared to Soxhlet or ultrasonic methods—while maintaining quantitative recovery (RSD < 4.2%, n = 6).
FAQ
What types of solvents are compatible with the MKX-E1G6A?
Polar solvents (e.g., water, methanol, ethanol, acetone) are fully supported. Low-dielectric solvents (e.g., hexane, toluene) require auxiliary absorbers or mixed-phase systems; custom vessel configurations (100–500 mL) are available for such applications.
Is the system suitable for method validation under ISO/IEC 17025?
Yes—the system’s closed-loop temperature/pressure control, traceable calibration paths, and deterministic power delivery support repeatability (RSD ≤ 3.1%) and intermediate precision studies required for accredited testing laboratories.
Can extraction data be integrated into a LIMS or ELN?
CSV exports are structured for direct ingestion into common LIMS platforms; API-based integration (RESTful JSON over HTTPS) is available as a firmware upgrade option.
What maintenance is required for long-term reliability?
Annual verification of microwave leakage, fiber-optic sensor calibration, and pressure transducer zero-point drift is recommended. The PTFE cavity coating requires no scheduled replacement under normal operating conditions (≤220 °C, ≤3 MPa).
Does the system support unattended overnight operation?
Yes—programmable auto-shutdown, thermal cutoffs, and door interlocks permit secure unattended runs; however, volatile solvent extractions must be conducted in ventilated enclosures per local EH&S regulations.
