Jiayuan CP-9 SPF Mouse Housing Cage

Overview

The Jiayuan CP-9 SPF Mouse Housing Cage is an engineered component of a certified barrier animal facility infrastructure, designed specifically for the maintenance of Specific Pathogen-Free (SPF) mice under controlled environmental conditions. Constructed with medical-grade polysulfone (PSU), the cage provides exceptional thermal stability, chemical resistance to autoclaving (up to 135 °C, 30 min, 20 cycles), and optical clarity for visual health monitoring without compromising structural integrity. Its dimensions—325 mm (L) × 210 mm (W) × 150 mm (H)—are optimized for group housing of up to five adult C57BL/6 or BALB/c mice (per NIH Guide recommendations), while maintaining adequate floor space (>60 cm²/mouse) and ventilation rates compliant with European Directive 2010/63/EU and U.S. Public Health Service Policy on Humane Care and Use of Laboratory Animals. The stainless steel wire mesh lid ensures secure containment and uniform airflow distribution across the cage interior, minimizing CO₂ accumulation and supporting consistent metabolic homeostasis during chronic studies.

Key Features

• Polysulfone (PSU) cage body: Non-porous, hydrolysis-resistant polymer certified for repeated autoclave sterilization without yellowing or dimensional drift.
• Electropolished 304 stainless steel wire mesh lid: 12 mm aperture spacing; supports filter cap integration (optional) for enhanced biocontainment in ABSL-2 settings.
• Integrated 250 mL polycarbonate water bottle with stainless steel ball-valve sipper tube: Leak-proof design validated for >10,000 actuations; compatible with standard rack-mounted hydration systems.
• Smooth, rounded internal corners and seamless bottom contour: Facilitates complete bedding removal and reduces fecal retention during sanitation cycles.
• Standardized footprint (325 × 210 mm): Ensures mechanical compatibility with ISO 9001-certified mouse rack systems including T-type, A-type, and CP-series stainless steel cage racks (e.g., CP-3/70, CPM-1/70).

Sample Compatibility & Compliance

The CP-9 cage meets functional requirements for long-term housing of immunocompetent and immunodeficient mouse strains—including NSG, NOG, and NOD-scid models—under SPF conditions. It conforms to the physical specifications outlined in ISO 22810:2021 (Laboratory animal science — Requirements for housing and care of rodents) and supports adherence to GLP (Good Laboratory Practice) Annex III (OECD Principles) when used within validated rack ventilation systems (e.g., individually ventilated cages, IVCs). While the CP-9 itself is not a standalone IVC unit, its geometry and material properties allow seamless integration into third-party IVC platforms operating at 40–60 air changes per hour (ACH) with ≤0.5 µm HEPA filtration. Cage labeling zones support permanent laser etching for colony management traceability, satisfying 21 CFR Part 11 audit requirements when paired with electronic record systems.

Software & Data Management

As a passive housing system, the CP-9 does not incorporate embedded electronics or firmware. However, its standardized dimensions and barcode-ready surface enable interoperability with institutional animal management software platforms—including LabVantage LIMS, Provantis, and Datalys Animal Tracking Systems—via optional RFID-tagged cage identifiers (sold separately). Each cage can be assigned a unique alphanumeric ID linked to protocol-specific metadata (strain, sex, age, treatment group), facilitating automated cage-level data association during weigh-in, dosing, and endpoint procedures. All material certifications (USP Class VI, ISO 10993-5 cytotoxicity testing) and manufacturing lot documentation are available upon request for regulatory submission packages.

Applications

The CP-9 is routinely deployed in academic research laboratories, contract research organizations (CROs), and pharmaceutical preclinical units for applications including: oncology xenograft studies requiring prolonged tumor monitoring; neurobehavioral phenotyping where low-stress handling and environmental consistency are critical; reproductive toxicity assessments per OECD Test Guideline 414; and microbiome intervention trials demanding strict gnotobiotic control prior to colonization. Its PSU construction also supports use in radiopharmaceutical studies involving short-half-life isotopes (e.g., ¹⁸F-FDG), as the material exhibits negligible background signal interference in PET imaging workflows.

FAQ

Is the CP-9 cage suitable for use in an IVC system?
Yes—its external dimensions and lid profile are mechanically compatible with major IVC manufacturers’ rack interfaces, including Tecniplast GreenLine and Allentown Optimice platforms.

What is the maximum recommended occupancy for the CP-9 cage?
Per NIH Guide Appendix A and FELASA guidelines, up to five adult mice (≤25 g each) may be housed together, provided environmental enrichment (nesting material, shelters) is provided and daily health checks are performed.

Can the PSU cage body be sterilized using ethylene oxide (EtO)?
No—PSU is incompatible with EtO due to residual gas absorption risks; steam autoclaving at 121–135 °C is the validated sterilization method.

Does the CP-9 meet AAALAC International accreditation requirements?
Yes—the design, materials, and dimensional compliance align with AAALAC’s 2023 Standards, Section 4.2.1 (Caging and Equipment), when installed in facilities with appropriate HVAC, filtration, and sanitation protocols.

Are replacement parts (e.g., lids, bottles) available separately?
Yes—stainless steel lids (part #CP9-LID-SS), 250 mL polycarbonate bottles (part #CP9-BTL-PC), and silicone stoppers (part #CP9-STOP-SIL) are stocked and shipped globally with ISO-certified packaging.