English Product Name

Overview

The Jiayuan GA56 IVC (Individually Ventilated Cage) System is an engineered environmental control platform designed for housing laboratory mice under barrier-level conditions. It operates on the principle of positive-pressure, individually ducted ventilation—each cage receives filtered, conditioned air via a dedicated low-velocity supply channel, while exhaust air is separately extracted through a dedicated path. This architecture eliminates cross-contamination between cages and maintains strict microbiological isolation per NIH Guide and AAALAC International standards. The system integrates a centralized air-handling unit with German-sourced centrifugal blowers, precision-matched variable-frequency drives (VFD), and a microprocessor-based control interface. Its core function is to sustain defined thermal, hygric, and aerodynamic parameters across all 56 cages simultaneously—ensuring reproducible housing conditions essential for preclinical pharmacology, immunology, and transgenic studies.

Key Features

• Color TFT touchscreen HMI with real-time display of cage-level temperature (±0.5°C), relative humidity (±3% RH), differential pressure (±1 Pa), cumulative runtime, and airflow status
• Patented static-pressure plenum design: laminar, low-velocity (<0.18 m/s) air delivery via perforated baffle plates ensures uniform distribution across the animal living zone without turbulence or drafts
• VFD-controlled supply and exhaust fans enable dynamic adjustment of air changes per hour (10–20 ACH) and inter-cage pressure gradients (20–50 Pa)
• Fail-safe engineering: integrated power-loss alarm, over/under temperature & humidity alerts, high/low differential pressure warning, and automatic valve closure upon cage removal
• Medical-grade silicone gaskets on all cage doors and access panels ensure leak-tight sealing compliant with ISO 14644-1 Class 5 requirements
• PSU (polyphenylsulfone) cage bodies: USP Class VI certified, resistant to autoclaving (150°C, 15 psi, 30 min), compatible with common disinfectants (e.g., 70% ethanol, 1% sodium hypochlorite, hydrogen peroxide vapor)
• Dual redundant safety pathways: passive ventilation channels remain open during power failure to prevent hypoxia; battery-backed alarm system triggers audible/visual notification

Sample Compatibility & Compliance

The GA56 system accommodates standard IVC-compatible mouse cages (up to 56 units in a single column configuration, 7 tiers × 8 columns). Each cage supports up to 5 adult C57BL/6 mice (or equivalent strain weight/size) without compromising airflow uniformity or thermal stability. All materials meet ISO 10993-5 (cytotoxicity) and ISO 10993-10 (irritation/sensitization) biocompatibility criteria. The system architecture aligns with AAALAC International’s Guide for the Care and Use of Laboratory Animals (9th ed.), EU Directive 2010/63/EU Annex III, and Chinese GB 14925-2010 standards for laboratory animal environments. Optional validation packages support IQ/OQ documentation for GLP-compliant facilities.

Software & Data Management

The embedded controller logs timestamped environmental data (temperature, humidity, pressure, fan speed, runtime) to internal flash memory (≥30 days retention). Data export is supported via USB 2.0 to CSV format for integration into institutional LIMS or electronic lab notebooks. Audit trail functionality records all parameter modifications, user logins, and alarm events—meeting FDA 21 CFR Part 11 requirements when paired with institutional identity management protocols. Remote monitoring is achievable via optional RS485-to-Ethernet gateway (not included), enabling SNMP-based integration into facility-wide BMS platforms.

Applications

This IVC system is validated for long-term housing of immunocompromised, genetically modified, and pathogen-free mouse models—including NSG, NOG, and humanized CD34+ engrafted strains. Its stable microenvironment supports behavioral phenotyping, chronic dosing studies, and longitudinal imaging where environmental consistency directly impacts endpoint variability. The GA56 configuration is particularly suited for medium-throughput screening programs requiring parallel cohort management under identical atmospheric conditions—reducing inter-cage variance in cytokine profiling, microbiome analysis, and metabolic phenotyping assays.

FAQ

What is the maximum autoclave cycle tolerance for the PSU cages?

Cages are rated for repeated autoclaving at 150°C, 15 psi (103 kPa) for 30 minutes without dimensional deformation or loss of optical clarity.

Does the system support integration with third-party environmental monitoring software?

Yes—via Modbus RTU over RS485 (optional gateway required); raw sensor outputs are accessible for custom SCADA or LabVIEW integration.

How is cage-level pressure gradient calibrated and verified?

Each cage port includes a calibrated differential pressure tap; verification is performed using a NIST-traceable manometer during installation qualification (IQ) and annually during operational qualification (OQ).

Is HEPA filter replacement tracked automatically?

Yes—the controller calculates cumulative fan runtime and triggers a maintenance alert when approaching the manufacturer-recommended 6-month or 4,000-hour service interval, whichever occurs first.

Can the system be expanded beyond 56 cages?

The GA56 is a fixed-configuration unit; scalable deployments require multiple GA56 units operated in master-slave mode via shared BMS coordination—not daisy-chained physically.