Liebherr SRFvg 4001 Laboratory Refrigerator

Overview

The Liebherr SRFvg 4001 is a precision-engineered laboratory refrigerator designed for mission-critical cold storage of biologics, vaccines, pharmaceuticals, clinical specimens, and research reagents. Built to meet the stringent environmental control requirements of GLP, GMP, and ISO 15190-compliant laboratories, this unit employs forced-air convection cooling with microprocessor-controlled thermal management to maintain stable, uniform temperatures across its entire storage volume. Its operational range of +3 °C to +16 °C—optimized for refrigerated (not frozen) storage—is validated to deliver ≤ ±2 °C temperature deviation from setpoint under standard ambient conditions (ISO 554/ISO 15190 test protocols), ensuring minimal thermal stress on thermolabile compounds. The cabinet’s robust steel construction, high-efficiency R600a refrigeration system, and vacuum-insulated door gaskets collectively minimize thermal leakage and energy consumption—245 kWh/year—while maintaining acoustic performance at ≤49 dB(A), suitable for shared lab environments.

Key Features

• Precision temperature control with ±2 °C stability across full load and ambient variations (+10 °C to +35 °C)
• +2 °C Freeze Protection Device: automatically activates alarm and initiates corrective action if internal temperature drops below +2 °C, preventing accidental freezing of sensitive biologicals
• Forced-air convection system with automatic defrost cycle ensures uniform airflow distribution and eliminates manual maintenance intervals
• Mechanical dual-key lock provides physical access control—critical for compliance with EU Annex 1, USP , and FDA 21 CFR Part 11 data integrity expectations for restricted-access storage
• Monochrome touchscreen interface with intuitive menu navigation supports real-time monitoring of setpoint, actual temperature, alarm status, and system diagnostics
• Top-mounted switchable LED lighting enables visual inspection without compromising thermal integrity or introducing radiant heat
• Five adjustable, plastic-coated wire shelves (460 × 423 mm usable area; 45 kg load capacity each) allow flexible configuration for vials, trays, and secondary containers
• Optional WiFi/LAN connectivity enables remote monitoring, event logging, and integration into centralized laboratory infrastructure management platforms

Sample Compatibility & Compliance

The SRFvg 4001 is validated for long-term storage of temperature-sensitive life science materials including monoclonal antibodies, cell culture media, enzyme preparations, DNA/RNA stocks, and vaccine formulations requiring uninterrupted refrigeration. Its design conforms to IEC 61010-1 (Safety Requirements for Electrical Equipment for Measurement, Control, and Laboratory Use) and IEC 61326-1 (EMC for Laboratory Equipment). Temperature mapping reports per ISO 14644-3 and qualification documentation (IQ/OQ) are available upon request to support regulatory submissions under EMA, FDA, or PMDA review pathways. The unit meets WHO Technical Report Series No. 961 (Annex 9) requirements for vaccine cold chain integrity and supports audit readiness for ISO/IEC 17025-accredited testing laboratories.

Software & Data Management

While the base model features a local monochrome display for real-time parameter viewing and alarm acknowledgment, the optional LAN/WiFi interface enables seamless integration with laboratory information management systems (LIMS) and electronic lab notebooks (ELN). When enabled, the unit logs timestamped temperature readings at user-configurable intervals (1–60 min), stores up to 30 days of historical data onboard, and transmits critical events—including power interruption, door-open duration >30 s, and out-of-spec temperature excursions—to designated email or SNMP endpoints. All logged data include digital signatures and immutable timestamps, satisfying ALCOA+ principles (Attributable, Legible, Contemporaneous, Original, Accurate, Complete, Consistent, Enduring, Available) required for 21 CFR Part 11 compliance in regulated environments.

Applications

• Stable refrigerated storage of clinical trial biospecimens (serum, plasma, PBMCs) per ISBER Best Practices
• Short- to medium-term holding of QC reference standards and calibration materials in pharmaceutical quality control labs
• Vaccine inventory management in hospital pharmacy and public health departments adhering to CDC Vaccine Storage and Handling Toolkit guidelines
• Reagent and assay kit storage in molecular diagnostics laboratories performing PCR, ELISA, and flow cytometry workflows
• Backup cold storage for ultra-low temperature freezers during maintenance cycles or power contingency planning

FAQ

What is the validated temperature uniformity across the chamber volume?
Temperature mapping per ISO 14644-3 confirms ≤ ±1.8 °C variation between nine defined test points under static load conditions at +8 °C setpoint.
Does the unit support continuous temperature monitoring with electronic records?
Yes—when equipped with the optional LAN/WiFi module, it supports automated data export, configurable alarm thresholds, and audit-trail-enabled logging compliant with 21 CFR Part 11.
Is the +2 °C Freeze Protection Device programmable or fixed?
It is a hardware-integrated safety function with no user adjustment; activation occurs automatically at +2.0 °C and cannot be disabled.
Can the refrigerator be installed in non-climate-controlled corridors?
Operation is certified only within ambient temperatures of +10 °C to +35 °C; installation outside this range may compromise temperature stability and void warranty.
Are calibration certificates and qualification documentation included?
Factory calibration certificate is supplied; IQ/OQ protocols and temperature mapping reports are available as optional service packages.