Hanuo FS-1 Adjustable High-Speed Electric Homogenizer

Overview

The Hanuo FS-1 Adjustable High-Speed Electric Homogenizer is a benchtop mechanical homogenization system engineered for reproducible sample disruption, emulsification, dispersion, and suspension preparation in life science, environmental, agricultural, food safety, and industrial R&D laboratories. It operates on the principle of high-shear rotor-stator homogenization: rotational energy from a precisely controlled motor is transferred via a stainless-steel drive shaft to interchangeable cutting blades, generating intense hydrodynamic shear forces within the sample vessel. This mechanism enables efficient cell lysis, tissue homogenization, nanoparticle dispersion, and uniform phase mixing—particularly where thermal sensitivity or chemical compatibility precludes ultrasonic or high-pressure methods. Designed for routine use in QC/QA workflows and exploratory research, the FS-1 delivers consistent mechanical energy input across defined time intervals, supporting method transfer and inter-laboratory comparability under standard operating conditions.

Key Features

• Stepless electronic speed control (0–22,000 rpm) allows precise adjustment of shear intensity to match sample viscosity, particle size, and thermal stability requirements.
• Six standardized homogenization vessels (5, 15, 25, 50, 100, and 150 mL) are constructed from borosilicate glass or compatible polymers, each fitted with a dedicated stainless-steel blade assembly optimized for volume-specific flow dynamics.
• Six thermally insulated cups accommodate external temperature management: users may circulate water, ice-water mixtures, or glycol-based coolants to maintain samples between ~0 °C and 60 °C during processing—critical for preserving enzyme activity, preventing protein denaturation, or controlling exothermic reactions.
• Integrated mechanical positioning system ensures coaxial alignment between drive shaft and blade hub, minimizing vibration, reducing bearing wear, and enhancing operational stability during extended cycles.
• Robust aluminum alloy housing with reinforced base provides structural rigidity and electromagnetic shielding; the 185 W induction motor is rated for intermittent duty (5 min max continuous operation), complying with IEC 61000-3-2 harmonic current emission standards.
• Front-panel digital display (optional on upgraded variants) indicates real-time RPM and elapsed run time; all electrical components meet CE-marked safety requirements for Class I laboratory equipment.

Sample Compatibility & Compliance

The FS-1 accommodates aqueous suspensions, soft tissues (e.g., liver, spleen, plant leaves), bacterial pellets, colloidal dispersions, and viscous food matrices—including dairy emulsions, sauces, and homogenized feedstock. It is not intended for abrasive slurries, highly fibrous materials, or organic solvents incompatible with standard gasket elastomers (EPDM/NBR). The system supports GLP-aligned documentation practices: operator-defined protocols (speed, duration, vessel type) can be logged manually or integrated into LIMS via external timing devices. While not certified to ISO/IEC 17025 or FDA 21 CFR Part 11 out-of-the-box, its mechanical repeatability and traceable parameter settings facilitate validation per internal SOPs or ASTM D4097 (Standard Practice for Homogenization of Biological Samples).

Software & Data Management

The FS-1 operates as a stand-alone instrument without embedded firmware or proprietary software. All operational parameters are set manually via analog potentiometer and mechanical timer. For regulated environments, users implement external data capture solutions—such as calibrated stopwatch logging, video-recorded operation, or integration with programmable logic controllers (PLCs) for automated start/stop sequencing. Audit trails may be maintained in accordance with ISO 15195:2018 (requirements for reference measurement laboratories) when paired with certified torque calibration standards and periodic speed verification using optical tachometry.

Applications

• Pre-analytical sample preparation for ELISA, PCR, and Western blotting—ensuring complete lysis of mammalian cells and subcellular fractionation.
• Environmental monitoring: homogenization of soil extracts, sediment cores, and wastewater biofilms prior to microbial enumeration or heavy metal analysis.
• Food safety testing: uniform dispersion of pathogen-spiked food matrices (e.g., ground meat, leafy greens) for ISO 11290-1 enrichment protocols.
• Agricultural research: extraction of phytochemicals from plant tissues under controlled thermal conditions to minimize oxidative degradation.
• Pharmaceutical excipient development: wet milling and stabilization of nano-suspensions for oral solid dosage forms.

FAQ

What is the maximum recommended continuous operating time?
The FS-1 is rated for up to 5 minutes of uninterrupted operation at full speed to prevent motor overheating and ensure long-term bearing integrity.
Can the homogenizer be used with corrosive or flammable solvents?
Only solvents chemically compatible with borosilicate glass, stainless-steel 316 blades, and EPDM/NBR sealing compounds should be used; consult the Material Safety Data Sheet (MSDS) for each reagent prior to processing.
Is speed calibration traceable to national standards?
Yes—users may verify rotational speed using a NIST-traceable handheld optical tachometer; factory calibration certificates are available upon request for IQ/OQ documentation.
Does the unit support GMP-compliant operation?
While the FS-1 lacks built-in electronic audit trail functionality, its mechanical design, repeatable speed control, and modular vessel system enable qualification under GMP Annex 15 guidelines when supported by validated procedures and maintenance records.
Are replacement blades and vessels available as consumables?
Yes—Hanuo supplies OEM-certified spare parts including blade assemblies, drive shafts, and calibrated vessel sets, all manufactured to dimensional tolerances specified in the original engineering drawings.