Jinshi Vap 01 Vacuum Centrifugal Concentrator

Overview

The Jinshi Vap 01 Vacuum Centrifugal Concentrator is an engineered solution for gentle, efficient removal of volatile solvents from biological, pharmaceutical, and analytical samples under reduced pressure and controlled thermal conditions. It operates on the principle of simultaneous centrifugation, vacuum application, and regulated heating—enabling solvent evaporation while preventing sample loss due to bumping, foaming, or aerosol formation. Unlike simple rotary evaporators, the Vap 01 maintains sample integrity by applying centrifugal force (up to 500 × g, depending on rotor configuration) to retain liquid in tubes or microplates during rapid vapor phase transition. Its core architecture integrates a sealed, temperature-controlled rotor chamber with a high-efficiency vacuum interface, allowing precise control over evaporation kinetics across diverse solvent classes—from low-boiling chloroform (bp 61 °C) and ethanol (bp 78 °C) to high-boiling aqueous buffers, DMSO (bp 189 °C), DMF (bp 153 °C), and NMP (bp 202 °C). The system is designed for routine use in QC laboratories, biopharma process development, and academic proteomics workflows where reproducible concentration without analyte degradation is critical.

Key Features

• Temperature-regulated rotor chamber with PID-controlled heating from ambient +5 °C to 50 °C, ensuring consistent energy input without thermal overshoot
• Centrifugal acceleration up to 500 × g (model-dependent), minimizing cross-contamination and enabling parallel processing of up to 48 × 1.5 mL tubes or 24 × 5 mL vials
• Modular vacuum compatibility: supports scroll dry pumps (oil-free operation), chemical-resistant diaphragm pumps (for aggressive solvents), and direct integration with lyophilizer vacuum manifolds
• Optional cold trap (−50 °C condenser) recommended for volumes exceeding 100 mL per run to enhance solvent recovery and reduce pump load
• Robust stainless-steel chamber construction with reinforced door seal and integrated safety interlock for vacuum and rotation synchronization
• Programmable time-based operation with automatic shutdown upon completion or vacuum loss detection

Sample Compatibility & Compliance

The Vap 01 accommodates standard labware including Eppendorf-style microcentrifuge tubes (0.2–50 mL), PCR plates, deep-well plates, and custom glass vials with O-ring sealing. It is validated for use with aqueous, organic, and mixed-phase solutions common in nucleic acid purification, peptide synthesis, metabolite extraction, and HPLC fraction concentration. While not certified to ISO/IEC 17025 or FDA 21 CFR Part 11 out-of-the-box, its operational parameters—including temperature logging (via optional RS485/Modbus output), vacuum stability monitoring, and programmable step profiles—support GLP/GMP-aligned documentation when integrated into validated laboratory information management systems (LIMS). The system complies with IEC 61010-1:2010 for electrical safety and EN 61326-1:2013 for electromagnetic compatibility.

Software & Data Management

The Vap 01 features a front-panel LCD interface with intuitive menu navigation for setting time, temperature, and vacuum ramp profiles. For advanced deployment, optional serial communication (RS232/RS485) enables remote parameter control and real-time data logging via third-party SCADA or ELN platforms. Audit trail functionality—including operator ID tagging, parameter change timestamps, and cycle completion reports—can be implemented through external software integration. No proprietary cloud service or vendor-hosted platform is required; all data remains local and exportable in CSV format for traceability in regulated environments.

Applications

• Concentration of DNA/RNA eluates post-column purification prior to sequencing or qPCR
• Removal of acetonitrile or methanol from LC-MS fractions without thermal decomposition of labile metabolites
• Preparative-scale solvent exchange in antibody-drug conjugate (ADC) intermediate processing
• Parallel concentration of 96-well plate samples in high-throughput screening assays
• Integrated workflow with lyophilizers: vacuum transfer from Vap 01 chamber to freeze-dryer condenser enables seamless transition from concentration to lyophilization without sample handling
• Residue recovery from reaction mixtures containing DMF or NMP in synthetic chemistry labs

FAQ

What vacuum pumps are compatible with the Vap 01?
Scroll dry pumps are recommended for general-purpose use; chemical diaphragm pumps are advised when processing halogenated or acidic vapors. Lyophilizer vacuum manifolds may be directly connected using optional multi-port adapters.
Is a cold trap necessary for all applications?
A cold trap is not mandatory for small-volume (<100 mL) runs with low-boiling solvents, but it significantly improves efficiency and extends pump life for aqueous or high-boiling solvent removal.
Can the Vap 01 be used for lyophilization?
No—it is not a freeze dryer. However, it can be coupled with compatible lyophilizers (e.g., Jinshi Pro-series) to form a hybrid concentrator–lyophilizer system for sequential concentration and drying.
What is the maximum sample volume per run?
Total capacity depends on rotor configuration; standard configurations support up to 4 L of solvent removal per 24-hour period under continuous operation with optimized vacuum and temperature settings.
Does the system support automated method recall?
Yes—up to 10 user-defined protocols can be saved locally on the device, each with independent time, temperature, and vacuum ramp parameters.