METTLER TOLEDO MA204/A Analytical Balance

Overview

The METTLER TOLEDO MA204/A Analytical Balance is a high-precision laboratory instrument engineered for routine analytical weighing tasks requiring trace-level accuracy and long-term reliability. Based on electromagnetic force compensation (EMFC) technology, it delivers stable, drift-free measurements under variable environmental conditions—including minor air currents, temperature fluctuations, and mechanical vibrations common in shared lab spaces. With a maximum capacity of 220 g and readability of 0.1 mg, the MA204/A meets the performance criteria defined in USP for analytical balances and satisfies minimum weight requirements per USP (160 mg at ±0.1% tolerance, k=2). Its robust mechanical architecture—featuring a die-cast metal base, corrosion-resistant polymer housing, and precision-machined weighing pan—ensures structural integrity during repeated handling and exposure to solvents, acids, or bases typical in chemical QA/QC workflows.

Key Features

• Internal calibration system with motorized adjustment and automatic recalibration triggered by time, temperature drift, or user command—eliminating dependency on external weights and reducing operator error.
• Hybrid touch-and-button interface with intuitive icon-driven menu navigation, guided application workflows (e.g., formulation, differential weighing, statistics), and context-sensitive help prompts.
• High-brightness, anti-glare LCD display with adjustable contrast and large numeric font—optimized for readability under varied lighting, including fume hood environments.
• Dual communication interfaces: standard RS232 and USB-A ports support direct connection to PCs, printers, or LIMS; optional Bluetooth module enables wireless data transmission compliant with ISO/IEC 17025 documentation requirements.
• Multi-level password protection (operator, supervisor, service) enforces role-based access control—critical for audit readiness under FDA 21 CFR Part 11 and EU Annex 11 regulations.
• Integrated leveling assistance with visual tilt indicator and adjustable feet—ensuring optimal sensor alignment without external tools or bubble levels.

Sample Compatibility & Compliance

The MA204/A accommodates a broad range of sample types—from powdered reagents and crystalline standards to small-volume liquid containers and filter papers—thanks to its 90 mm diameter stainless-steel weighing pan and low-profile draft shield compatibility. Its chemically inert surface resists degradation from common laboratory agents including acetone, ethanol, 1 M HCl, and 1 M NaOH. The balance is type-approved for legal-for-trade applications in multiple jurisdictions (OIML R76, NTEP Class I) and conforms to international metrological standards including ISO 9001, ISO/IEC 17025, and EURAMET cg-18. Built-in compliance features include automatic logging of calibration events, user actions, and error codes—with timestamped records exportable via USB for GLP/GMP audit trails.

Software & Data Management

Data integrity is maintained through seamless integration with METTLER TOLEDO’s LabX™ Lite software (included) and full LabX™ platform (optional). LabX Lite supports automated result recording, customizable report templates (PDF/CSV), and electronic signature capture. All weighing sessions are tagged with operator ID, timestamp, balance ID, and environmental metadata (if connected to optional temperature/humidity sensors). Audit trail functionality complies with FDA 21 CFR Part 11 requirements, including immutable record retention, change history, and electronic signature validation. Raw data export preserves full measurement resolution (0.1 mg), enabling retrospective statistical analysis (e.g., repeatability trending, uncertainty budgeting per GUM).

Applications

The MA204/A serves as a foundational tool across regulated and non-regulated laboratories. In pharmaceutical QC labs, it supports raw material assay, reference standard preparation, and dissolution tablet weight checks per USP monographs. In academic research, it enables precise gravimetric preparation of molar solutions, catalyst loading, and thermogravimetric sample conditioning. Industrial chemistry labs rely on its stability for batch release testing, titrant standardization, and moisture content determination via loss-on-drying protocols. Its trade certification also permits use in contract manufacturing organizations (CMOs) for certified reference material (CRM) dispensing and packaging line verification.

FAQ

What is the minimum weight that can be reliably measured on the MA204/A according to USP guidelines?
The minimum weight is 160 mg (at ±0.1% tolerance, k=2), validated using the balance’s internal test weight and documented in the factory certificate.
Does the MA204/A support GLP-compliant electronic record keeping?
Yes—when used with LabX Lite or LabX software, all weighings generate timestamped, user-authenticated records with full audit trail capability per FDA 21 CFR Part 11.
Is external calibration required after installation?
No—internal calibration eliminates the need for external weights; however, periodic verification using traceable standards is recommended per ISO/IEC 17025 clause 5.10.
Can the balance operate inside a fume hood?
Yes—the MA204/A is rated for operation in controlled ventilation environments; draft shield compatibility and low air-current sensitivity ensure stable readings.
What materials are used in the construction of the weighing chamber and base?
The base is die-cast aluminum alloy; the housing is reinforced polyamide with UV-stabilized surface treatment; the pan is AISI 316 stainless steel.