METTLER TOLEDO EasyPlus ET58 Automatic Potentiometric Titrator

Overview

The METTLER TOLEDO EasyPlus ET58 is a compact, CE-compliant automatic potentiometric titrator engineered for precision, robustness, and operational simplicity in routine laboratory environments. It operates on the fundamental principle of potentiometric endpoint detection—measuring the potential difference between a reference electrode and an indicator electrode as titrant is incrementally delivered—enabling accurate determination of equivalence points in acid-base, redox, precipitation, and complexometric reactions. Designed for compliance with ISO/IEC 17025 and aligned with GLP/GMP documentation requirements, the ET58 delivers traceable, auditable results without requiring advanced electrochemical expertise. Its modular architecture supports integration into regulated workflows, including those governed by USP , ASTM E2087, and ISO 8587 for titrimetric analysis.

Key Features

• Intuitive 4.3-inch color touchscreen interface with context-sensitive navigation and multilingual support (English, German, French, Spanish, Chinese, Japanese), reducing operator training time and minimizing input errors.
• iTitrate™ intelligent method guidance—preconfigured titration templates for common applications (e.g., acid number, chloride, vitamin C, SO₂) auto-suggest optimal parameters (dosing mode, step size, endpoint criteria) based on sample matrix and analyte chemistry.
• Dual-electrode connectivity: Simultaneous support for pH/mV electrodes and polarizable redox electrodes, enabling seamless switching between direct, back-, blank, and concentration-standardization titrations.
• High-resolution measurement electronics: ±0.1 mV potential resolution and ±0.1 µA polarization current resolution ensure reliable detection of subtle inflection points, particularly critical in low-conductivity or high-buffer-capacity samples.
• Integrated magnetic stirrer control with adjustable speed (0–1200 rpm) and real-time feedback—eliminates mechanical coupling variability and improves reproducibility across heterogeneous or viscous matrices.
• USB-A and USB-B ports enable direct connection to METTLER TOLEDO EasyDirect™ Titration software (for data export, report generation, and audit trail management) or certified thermal printers (e.g., USB-P25) compliant with 21 CFR Part 11 requirements for electronic records.

Sample Compatibility & Compliance

The ET58 accommodates aqueous, alcoholic, and partially organic solvent systems—including ethanol/water mixtures for wine analysis and acetonitrile-based media for pharmaceutical assays. Its electrode interfaces accept standard BNC, DIN, and mini-DIN connectors, supporting glass pH electrodes, silver/silver chloride reference electrodes, platinum redox sensors, and ion-selective electrodes (e.g., Ag for Cl⁻, Cu for cyanide). The system meets IEC 61010-1 safety standards and carries CE marking for use in EU laboratories. For regulated environments, firmware supports user access levels, electronic signatures, and timestamped audit trails—fully compatible with FDA 21 CFR Part 11 when paired with validated EasyDirect™ software configurations.

Software & Data Management

EasyDirect™ Titration software provides full instrument control, real-time titration curve visualization, customizable report templates (PDF/CSV/XLSX), and secure data archiving. All raw sensor signals (E vs. V, dE/dV vs. V), calculated results (titer, concentration, % purity), and metadata (operator ID, date/time, method version, electrode calibration history) are stored with immutable timestamps. Audit trails record every parameter change, result modification, or user login—exportable in encrypted format for internal QA review or external regulatory inspection. No proprietary file formats are used; all exported data are human-readable and machine-parseable.

Applications

• Acid-base titrations: Determination of free fatty acids in edible oils (AOCS Cd 3d-63), total alkalinity in wastewater (ISO 9963-1), and titratable acidity in fruit juices and wines (OIV-OENO 422-2010).
• Redox titrations: Quantification of ascorbic acid in beverages (AOAC 967.21), reducing sugars in must (OIV-OENO 423-2010), and sulfite in white wine (AOAC 990.28).
• Precipitation titrations: Chloride analysis in drinking water (ISO 9297), salt content in dairy products (IDF 123:2013), and sulfur compounds in lubricating oils (ASTM D2624).
• Endpoint-controlled titrations: pH-stat titrations for enzyme activity assays, pKa determination of weak acids, and buffer capacity profiling in biopharmaceutical formulation development.

FAQ

Does the ET58 support GLP-compliant documentation?
Yes—when used with validated EasyDirect™ Titration software and configured with user authentication, electronic signatures, and audit-trail-enabled reporting, it fulfills core GLP documentation requirements per OECD Principles of Good Laboratory Practice.
Can the ET58 perform Karl Fischer coulometric titration?
No—the ET58 is designed exclusively for potentiometric titration. For moisture analysis via Karl Fischer, METTLER TOLEDO recommends the V30 or T50 series coulometric titrators.
Is electrode calibration traceable to NIST standards?
While the ET58 itself does not generate calibration certificates, it accepts NIST-traceable pH buffer solutions (e.g., NIST SRM 186, 187) and supports two-point pH calibration with slope and offset verification—fully documented within EasyDirect™ audit logs.
What maintenance is required for long-term reliability?
Routine maintenance includes quarterly verification of stirrer motor performance, annual verification of voltage/current measurement accuracy using certified calibrators (e.g., Fluke 5520A), and electrode storage per manufacturer guidelines—no internal recalibration tools are required.
Is remote monitoring or network integration possible?
The ET58 lacks built-in Ethernet or Wi-Fi; however, it can be connected via USB to a networked PC running EasyDirect™, enabling centralized data collection and remote supervision through secure virtual desktop infrastructure (VDI) deployments.