Titan HRC-16K Plus Benchtop High-Speed Refrigerated Centrifuge (Rotors Sold Separately)

Overview

The Titan HRC-16K Plus is a precision-engineered benchtop high-speed refrigerated centrifuge designed for routine and demanding separation tasks in life science, clinical diagnostics, pharmaceutical QA/QC, and academic research laboratories. It operates on the principle of sedimentation under controlled rotational force, where differential particle migration—governed by mass, density, shape, and medium viscosity—is accelerated via precisely regulated angular velocity and temperature. With a maximum rotational speed of 16,000 rpm and a peak relative centrifugal force (RCF) of 23,470 × g, the system delivers robust performance for pelleting subcellular organelles, precipitating nucleic acids, concentrating viruses, and clarifying viscous biological suspensions. Its integrated refrigeration system maintains sample temperature between –20 °C and +40 °C during operation, minimizing thermal degradation of thermolabile macromolecules such as enzymes, antibodies, and RNA.

Key Features

• Microprocessor-controlled brushless frequency-conversion motor ensures stable speed regulation with ±10 rpm accuracy across the full operational range.
• Intelligent pre-cooling function reduces chamber temperature to setpoint within 15 minutes prior to rotor insertion—critical for maintaining sample integrity during high-throughput workflows.
• Dual-layer stainless-steel chamber with vacuum-insulated door minimizes heat transfer and condensation buildup, supporting consistent thermal control even during extended runs.
• Real-time RCF calculation and display based on selected rotor geometry and actual rotational speed—eliminating manual conversion errors and enhancing protocol reproducibility.
• Automatic imbalance detection and dynamic compensation system halts operation if mass asymmetry exceeds 5 g per bucket, preventing mechanical stress and ensuring long-term rotor and drive train reliability.
• Three-stage deceleration profiles (fast, gentle, and “no-brake”) allow optimization of pellet integrity for fragile samples such as exosomes or primary cell lysates.

Sample Compatibility & Compliance

The HRC-16K Plus accommodates standard fixed-angle rotors compatible with 0.2–100 mL tubes, including conical-bottom polypropylene, polycarbonate, and ultra-clear centrifuge tubes. It supports ISO 13485-compliant manufacturing processes and meets IEC 61010-1:2012 safety standards for laboratory electrical equipment. While not certified for GLP/GMP environments out-of-the-box, its audit-ready runtime logs—including start/stop timestamps, temperature history, speed profile, and error codes—can be exported via USB interface to support internal SOP compliance and FDA 21 CFR Part 11–aligned documentation practices when integrated into validated workflows. All rotors are balanced to ISO 1940 G2.5 grade and undergo full dynamic balancing verification prior to shipment.

Software & Data Management

The embedded control interface features a 5.7-inch TFT-LCD touchscreen with multilingual UI (English, German, French, Spanish, Japanese), enabling intuitive parameter entry, program storage (up to 99 user-defined protocols), and real-time graphical monitoring of temperature, speed, time, and RCF. Data logging records every run with timestamped metadata and is exportable in CSV format via USB 2.0 port. Optional TitanCentriLink PC software (v3.2+) provides remote monitoring, batch report generation, and integration with LIMS systems through configurable ODBC drivers—facilitating traceability in regulated environments requiring electronic record retention.

Applications

• Isolation of mitochondria, nuclei, and microsomal fractions from mammalian tissue homogenates.
• High-yield purification of plasmid DNA and genomic DNA using silica-membrane or phenol-chloroform extraction workflows.
• Concentration and purification of lentiviral and AAV vectors at clinical-grade titers.
• Routine serum/plasma separation in clinical chemistry labs with strict turnaround time requirements.
• Preparative centrifugation of nanoparticle dispersions (e.g., liposomes, polymeric micelles) for size distribution analysis by DLS or TEM.
• Clarification of bacterial and yeast lysates prior to affinity chromatography or SEC-MALS characterization.

FAQ

What rotor types are compatible with the HRC-16K Plus?
The centrifuge accepts all Titan-certified fixed-angle rotors with matching flange dimensions and max speed ratings ≥16,000 rpm—including 6×50 mL, 4×100 mL, and 12×15 mL configurations. Rotors must be purchased separately and are not included with base unit delivery.
Does the unit support automatic rotor recognition?
No—rotor identification is manual via touchscreen input. Users must select the installed rotor model before initiating a run to ensure accurate RCF calculation and safety interlock validation.
Can the centrifuge operate without refrigeration?
Yes—the cooling system can be disabled via software setting, allowing ambient-temperature operation for heat-stable samples or energy conservation during non-critical applications.
What is the acoustic noise level during operation at maximum speed?
Measured at 65 dB(A) at 1 m distance under standard installation conditions (level floor, no vibration isolation table), compliant with ISO 15712-2 for laboratory equipment noise emission.
Is service and calibration support available outside mainland China?
Titan provides international technical documentation and firmware updates via secure portal; field service and metrological calibration are delivered through authorized regional partners in EMEA, APAC, and North America under annual support contract agreements.