Sanotac SP2010 Preparative High-Pressure Solvent Delivery Pump (200 mL Head, 10 MPa)

Overview

The Sanotac SP2010 Preparative High-Pressure Solvent Delivery Pump is an engineered solution for precise, stable, and scalable liquid delivery in preparative chromatography, process development, and industrial-scale purification workflows. Designed around a dual-piston serial pumping architecture with floating piston technology, the SP2010 dynamically compensates for solvent compressibility and refilling lag—critical factors at elevated pressures and high flow rates. Its real-time chamber pressure feedback loop enables rapid response to system impedance changes, ensuring consistent volumetric displacement across the full operational range. Unlike basic constant-pressure pumps, the SP2010 operates as a true constant-flow pump, maintaining setpoint fidelity even under variable backpressure conditions typical of packed-bed columns, membrane filtration modules, or reaction quenching manifolds. The pump head—constructed from 316L stainless steel—is rated for continuous operation up to 10 MPa (1450 psi), supporting robust use with organic solvents, aqueous buffers, and mildly corrosive mobile phases.

Key Features

• Dual-piston serial drive with floating piston design: Minimizes seal wear and extends service life under sustained high-pressure operation.
• Advanced cam-profile flow compensation: Reduces pulsation amplitude to ≤0.2 MPa, delivering ultra-low baseline noise essential for UV/ELSD detection sensitivity in preparative LC.
• Multi-point flow calibration: User-accessible calibration across ten discrete flow points ensures traceable accuracy (±0.5%) and repeatability (RSD ≤0.1%) from 0.01 to 200.00 mL/min.
• Open communication protocol: RS232 and USB interfaces support bidirectional command exchange with third-party software (e.g., LabVIEW, Python-based automation suites) and integration into GMP-compliant control systems.
• Intuitive front-panel interface: 256×64 dot-matrix self-luminous LCD with uniform color rendering at all viewing angles and user-adjustable backlight intensity for glove-box or low-light lab environments.
• Ten programmable methods: Store and recall flow profiles, gradient ramps, and pause sequences—enabling reproducible method transfer between R&D and pilot-scale operations.

Sample Compatibility & Compliance

The SP2010 accommodates a broad spectrum of solvents—including acetonitrile, methanol, THF, DCM, and aqueous buffers—compatible with standard HPLC-grade tubing and fittings (1/16″ OD SS or PEEK). Its 316L stainless steel pump head meets ASTM A276 requirements for corrosion resistance and mechanical integrity. While not certified to ISO 9001 out-of-the-box, the pump’s design supports audit-ready documentation: all flow calibrations are timestamped and logged internally; firmware revision history is accessible via diagnostic mode; and hardware traceability (serial number, manufacturing batch) is engraved on the chassis. When deployed in regulated environments, the SP2010 can be validated per USP Analytical Instrument Qualification protocols and configured to comply with FDA 21 CFR Part 11 requirements when paired with compliant LIMS or CDS platforms that enforce electronic signatures and audit trails.

Software & Data Management

The SP2010 supports both standalone operation and computer-controlled sequencing. Its open ASCII-based command set allows seamless scripting for automated method execution, event-triggered flow changes, and real-time status polling (e.g., current pressure, actual flow, error codes). All parameters—including flow rate, pressure limit, gradient slope, and program step duration—are modifiable via ASCII commands or through Sanotac’s optional PC-based control suite (Windows 10/11 compatible). Internal memory retains ten user-defined programs with non-volatile storage, eliminating reconfiguration after power cycles. System logs—including runtime hours, total delivered volume, and fault events—are exportable via USB flash drive in CSV format for trend analysis and preventive maintenance scheduling.

Applications

• Preparative HPLC and flash chromatography: Delivering consistent 50–200 mL/min flows for column diameters from 20 mm to 100 mm ID.
• Process analytical technology (PAT) integration: Serving as a feed pump in continuous manufacturing loops with inline NIR or conductivity sensors.
• Reaction mixture delivery in flow chemistry: Precise metering of reagents into microreactors or packed-bed catalytic zones.
• Extraction system priming and elution: Supporting solid-phase extraction (SPE), accelerated solvent extraction (ASE), and supercritical fluid processing.
• Calibration standard delivery: Generating certified volumetric outputs for gravimetric or conductivity-based flowmeter validation.

FAQ

What is the maximum recommended operating pressure for continuous use?
The SP2010 is rated for continuous operation at ≤10 MPa (1450 psi) with the standard 316L stainless steel pump head.
Can the pump be used with aggressive solvents such as concentrated acids or halogenated hydrocarbons?
Compatibility depends on wetted material selection; 316L stainless steel is suitable for most common organics and buffered aqueous solutions but not recommended for prolonged exposure to hydrochloric acid, bromine, or hot chlorinated solvents without supplemental passivation or alternative head materials.
Is flow calibration traceable to national standards?
Yes—calibration is performed using gravimetric measurement against NIST-traceable mass standards; users may perform in-house recalibration using certified volumetric flasks and analytical balances per ISO/IEC 17025 guidelines.
Does the pump support gradient mixing when used with a binary or quaternary manifold?
The SP2010 itself is a single-channel solvent delivery unit; gradient formation requires external proportioning valves or a dedicated gradient module—though its programmable flow ramping enables synchronized multi-pump gradient control via external coordination.
How often does the high-pressure seal require replacement under normal operating conditions?
With proper solvent filtration (≤0.45 µm), regular degassing, and avoidance of particulate-laden mobile phases, the floating piston seal typically exceeds 6,000 hours of operation before scheduled replacement.