Sanotac LP0110 Prep-HPLC High-Pressure Solvent Delivery Pump (1000 mL Head, 10 MPa)

Overview

The Sanotac LP0110 Prep-HPLC High-Pressure Solvent Delivery Pump is an industrial-grade constant-flow pump engineered for preparative-scale liquid chromatography, continuous extraction, and high-throughput solvent delivery applications requiring precise, stable, and scalable flow control under elevated pressure. Operating on a dual-piston serial displacement principle with floating-piston architecture, the LP0110 dynamically compensates for solvent compressibility and refilling lag—critical factors in maintaining volumetric fidelity across wide flow ranges (0.1–1000.00 mL/min) and pressures up to 10 MPa. Its microprocessor-based control system integrates real-time chamber pressure feedback and cam-profile flow pulsation compensation, enabling baseline stability essential for UV detection, fraction collection synchronization, and multi-column parallel operation. Designed for integration into modular purification platforms—including standalone prep-LC systems, continuous chromatography skids, and custom process trains—the LP0110 meets the mechanical robustness and regulatory traceability expectations of GLP-compliant laboratories and pilot-scale manufacturing environments.

Key Features

• Dual-piston serial drive with floating-piston seal design—extends service life of high-pressure seals and maintains consistent volumetric displacement under thermal and pressure cycling.
• Real-time cavity pressure feedback loop—enables active correction of solvent compressibility effects, particularly critical when using acetonitrile, methanol, or CO₂-rich mobile phases.
• Cam-curve flow pulsation suppression—reduces pressure ripple to ≤0.5 MPa, minimizing baseline noise in UV-Vis and conductivity detectors during high-flow elution.
• Multi-point flow calibration algorithm—applies 10-point linearization across the full 0.1–1000 mL/min range, ensuring ±1.0% flow accuracy and ≤0.5% RSD repeatability per ICH Q2(R2) guidance.
• Open-protocol RS232/USB interface—supports bidirectional communication with third-party chromatography data systems (CDS), LIMS, or PLC-based automation frameworks without proprietary drivers.
• 10-user programmable methods—store and recall gradient profiles, flow ramps, hold steps, and pressure limits; each method supports time-based event triggering for synchronized valve switching or detector gain adjustment.
• Self-luminous 256×64 dot-matrix LCD—provides consistent contrast across viewing angles with adjustable backlight intensity, optimized for glove-box or hood-mounted installations.

Sample Compatibility & Compliance

The LP0110 accommodates a broad spectrum of solvents and suspensions common in preparative chromatography—including aqueous buffers, organic modifiers (e.g., THF, DCM, ethyl acetate), and mildly abrasive slurries (e.g., silica-based stationary phases at ≤5 µm). Its 316L stainless steel pump head and wetted-path components comply with ASTM F899 for corrosion resistance in chloride-containing media and meet ISO 8536-4 requirements for pressure-rated fluid handling components. While not certified for intrinsically safe (ATEX/IECEx) or pharmaceutical-grade cleanroom use out-of-the-box, the pump’s design supports validation per FDA 21 CFR Part 11 when integrated with audit-trail-enabled CDS software. It conforms to IEC 61000-6-2 (immunity) and IEC 61000-6-4 (emissions) for laboratory electromagnetic compatibility.

Software & Data Management

The LP0110 operates via embedded firmware supporting ASCII-based command sets over RS232 or USB virtual COM port. Full documentation of the communication protocol—including command syntax, status register mapping, and error code definitions—is publicly available, enabling seamless integration with LabVIEW, Python (pySerial), MATLAB, or custom SCADA interfaces. All flow and pressure setpoints, executed methods, and system alarms are timestamped and loggable. When paired with validated chromatography software (e.g., Chromeleon, Empower, or open-source OpenChrom), the pump supports electronic signature capture, change control tracking, and raw data archiving aligned with ALCOA+ principles. Firmware updates are delivered via signed binary files with SHA-256 checksum verification.

Applications

• Preparative HPLC purification of natural products, peptides, and synthetic intermediates at gram-to-kilogram scale.
• Continuous counter-current chromatography (CCC) and centrifugal partition chromatography (CPC) solvent delivery.
• High-flow flash chromatography systems requiring >500 mL/min throughput with pressure stability up to 10 MPa.
• Process analytical technology (PAT) workflows integrating inline UV, density, or pH sensors with closed-loop flow modulation.
• Method development for scale-up studies—leveraging identical fluidic behavior from analytical to preparative dimensions via flow-rate normalization.
• Automated solvent delivery in solid-phase extraction (SPE) manifolds and multi-step synthesis reactors.

FAQ

What materials are in contact with the fluid path?
The standard wetted path consists of 316L stainless steel (pump head, valves, tubing ports), sapphire ruby check valves, and fluoropolymer (FFKM) seals. PEEK or Hastelloy variants are available upon request for aggressive solvents.

Can the LP0110 be used in gradient mode with multiple solvent channels?
No—the LP0110 is a single-channel high-pressure pump. For binary or ternary gradients, it must be paired with a high-pressure mixing manifold or used downstream of a low-pressure quaternary blending module.

Is firmware update support provided after purchase?
Yes—Sanotac provides free firmware updates for the lifetime of the product, including bug fixes, enhanced communication reliability, and expanded command set features.

Does the pump include pressure overload protection?
Yes—integrated pressure transducer monitoring triggers automatic shutdown if pressure exceeds 10.5 MPa, with configurable hysteresis and manual reset requirement.

What is the recommended maintenance interval for the pump head seals?
Under typical operation (≤8 MPa, <500 mL/min, non-abrasive solvents), seal replacement is advised every 1,500–2,000 operating hours, documented in the maintenance logbook included with shipment.