Sanotac LP0310 Preparative High-Pressure Solvent Delivery Pump (3000 mL, 10 MPa)

Overview

The Sanotac LP0310 Preparative High-Pressure Solvent Delivery Pump is an engineered solution for demanding preparative chromatography, continuous extraction, and high-flow process-scale liquid handling applications. Designed around a dual-piston parallel architecture with floating piston technology, the LP0310 delivers stable, pulse-minimized solvent flow across an exceptionally wide dynamic range—from 0.1 mL/min to 3000.00 mL/min—while maintaining pressure stability up to 10 MPa (1450 psi). Its core operational principle relies on real-time chamber pressure feedback, synchronized dual-drive actuation, and solvent compressibility compensation algorithms, enabling precise volumetric delivery even with low-viscosity or compressible mobile phases. Unlike conventional analytical HPLC pumps, the LP0310 integrates industrial-grade hydraulics and thermal management (including active heat dissipation for sustained 2000 W operation), making it suitable for extended unattended runs in GMP-aligned purification workflows.

Key Features

• Dual-piston parallel pumping mechanism with floating piston seal design—reduces mechanical wear and extends seal lifetime to >10,000 hours under typical preparative operating conditions.
• High-fidelity flow control via cam-profile pulsation compensation and multi-point flow calibration curves—ensures linearity and repeatability across the full 0.1–3000 mL/min range.
• Real-time cavity pressure sensing and adaptive refill timing—dynamically compensates for solvent compressibility and dwell volume effects, minimizing gradient delay and improving method transfer fidelity.
• Self-luminous 256×64 dot-matrix LCD with uniform brightness and wide viewing-angle performance—optimized for glove-box, fume hood, and cleanroom environments where ambient lighting varies.
• Open-protocol RS232/USB interface compliant with standard SCPI command syntax—enables seamless integration with third-party chromatography data systems (CDS), LIMS, or custom Python/Node-RED automation frameworks.
• Ten user-defined program slots supporting independent flow rate ramping, step gradients, and hold segments—facilitates method development without external scripting.

Sample Compatibility & Compliance

The LP0310 accommodates a broad spectrum of solvents—including acetonitrile, methanol, THF, dichloromethane, and aqueous buffers—with compatibility validated for use with 316L stainless steel wetted parts. It meets mechanical safety requirements per IEC 61010-1:2010 and electromagnetic compatibility standards EN 61326-1:2013. While not certified as intrinsically safe, its sealed electronics enclosure and thermal cutoff protection support deployment in Class I, Division 2 hazardous locations when installed per local electrical codes. For regulated environments, audit trail functionality (via optional firmware upgrade) supports 21 CFR Part 11-compliant electronic records when paired with validated CDS software. The pump conforms to ISO 9001 manufacturing controls and is supplied with full traceable calibration certificates (flow & pressure) issued against NIST-traceable reference standards.

Software & Data Management

The LP0310 operates natively via front-panel control but is fully controllable through its open ASCII-based serial protocol—documented in the publicly available Communication Protocol Manual (Rev. 3.2). No proprietary drivers are required; standard terminal emulators or Python’s pySerial library suffice for basic command issuance (e.g., “FLOW=1500.0”, “START”, “PAUSE”). For enterprise integration, Sanotac provides SDK examples compatible with LabVIEW, MATLAB, and .NET Framework. All flow and pressure events are timestamped and logged internally (non-volatile memory, 10,000-entry buffer); logs export via USB mass storage mode in CSV format. Optional firmware enables TLS-secured MQTT publishing for cloud-based monitoring and predictive maintenance analytics.

Applications

• Preparative HPLC and flash chromatography systems requiring >1 L/min flow rates at ≤10 MPa backpressure.
• Continuous solvent extraction (CSE) and countercurrent chromatography (CCC) setups with variable-density mobile phase delivery.
• Automated reaction quenching and reagent dosing in flow chemistry reactors (e.g., Corning AFR, Vapourtec R-Series).
• Column packing and system priming in large-bore (≥50 mm ID) chromatographic columns used in bioprocessing and natural product isolation.
• Mobile phase delivery for inline SFC (supercritical fluid chromatography) co-solvent blending, when interfaced with CO₂ delivery modules.

FAQ

Does the LP0310 support gradient elution with multiple solvent channels?
No—the LP0310 is a single-channel high-flow pump. Gradient capability requires external low-flow proportioning valves or integration with a separate quaternary mixing module.
What is the maximum recommended viscosity limit for continuous operation?
The pump is rated for solvents with dynamic viscosity up to 5 mPa·s at 25 °C. Higher viscosities require derating of maximum pressure and flow to maintain seal integrity and thermal stability.
Is the 316L pump head resistant to hydrochloric acid or sodium hypochlorite solutions?
316L stainless steel exhibits limited resistance to halide-containing oxidizers. Use of such solvents is not recommended without prior compatibility testing and validation of corrosion rates per ASTM G31.
Can the LP0310 be operated in closed-loop pressure control mode?
No—it operates exclusively in flow-rate control mode. Pressure is monitored as a safety interlock parameter but is not actively regulated.
What is the warranty coverage and service support structure outside China?
Sanotac offers a 24-month limited warranty covering parts and labor. Global technical support is provided via regional authorized service partners in the EU, US, and APAC regions, with spare parts stocked in Rotterdam, Chicago, and Singapore distribution hubs.