Masterflex MFLX77976-40 Mastersense Precision Dispensing Peristaltic Pump System
| Brand | Masterflex |
|---|---|
| Origin | USA |
| Model | MFLX77976-40 |
| Flow Rate Range | 0.007–635 mL/min |
| Speed Control Signal | 4–20 mA |
| Max Speed | 250 rpm |
| Accuracy | ±0.5% |
| Enclosure Material | 316 Stainless Steel |
| IP Rating | IP66 / NEMA 4X |
| Touchscreen | 5" Capacitive TFT/RGB (800 × 480 px) |
| Motor | Brushless DC with Encoder, 75 W |
| Pump Head Type | Ultrapharm™ Double-Y L/S® with Planetary Drive & Offset Rollers |
| Compliance | UL, cUL, CE |
| Warranty | 2 Years |
Overview
The Masterflex MFLX77976-40 Mastersense Precision Dispensing Peristaltic Pump System is an engineered solution for high-integrity liquid handling in regulated pharmaceutical, biotechnology, and analytical laboratory environments. Based on positive displacement peristaltic pumping principles, it delivers precise, pulse-minimized fluid transfer without product contact with mechanical components—ensuring sterility, minimizing shear stress, and preserving molecular integrity of sensitive biologics, cell suspensions, and viscous formulations. Its core architecture integrates a planetary-gear-driven Ultrapharm™ pump head with offset rollers and a patented Double-Y L/S® tubing configuration, enabling linear flow response across the full operational range while maintaining volumetric repeatability within ±0.5%. Designed for integration into cleanroom workflows (ISO Class 5–8), the system features a fully sealed 316 stainless steel enclosure rated IP66/NEMA 4X—capable of withstanding frequent washdowns and compatible with vaporized hydrogen peroxide (VHP) decontamination protocols.
Key Features
- Planetary-drive pump head with eight offset rollers: Eliminates axial drag on tubing, reduces pulsation by >40% versus conventional designs, and extends tubing service life by up to 3× through uniform compression geometry.
- Double-Y L/S® tubing configuration: Enables dual-channel operation at reduced rotational speeds—maintaining target flow rates while lowering shear forces critical for fragile cells, proteins, or nanoparticle suspensions.
- 5-inch capacitive TFT/RGB touchscreen (800 × 480 px): Glove-compatible interface with wide viewing angles; supports intuitive programming of dispense volume, timing, acceleration ramps, drip prevention, and multi-step batch sequences.
- Multi-layer access control: Three-tier security model (Operator, Technician, Administrator) governs parameter editing, calibration, firmware updates, and remote command execution—supporting ALCOA+ data integrity requirements.
- Real-time remote monitoring via MasterflexLive®: Secure cloud platform providing 24/7 visibility into speed, flow status, tubing wear indicators, error logs, and calibration history—with configurable push notifications for process deviations.
- Industrial-grade connectivity: Native EtherNet/IP and Profibus support for PLC/SCADA integration; optional Wi-Fi and analog I/O (4–20 mA, 0–10 V) for legacy system compatibility and closed-loop feedback control.
Sample Compatibility & Compliance
The MFLX77976-40 accommodates a broad spectrum of fluid types—including aqueous buffers, glycerol-based formulations, low-conductivity solvents, and shear-sensitive biologics—without risk of cross-contamination or degradation. Compatible tubing sets (L/S® sizes 13, 14, 16, 17, 25) are certified for USP Class VI and FDA-compliant materials, with optional 316L stainless steel pump heads validated for autoclave cycles (10× at 121°C, 15 psi). The system meets UL 61010-1, CSA C22.2 No. 61010-1, and EN 61000-6-2/6-4 electromagnetic compatibility standards. Its architecture supports audit-ready operation under 21 CFR Part 11 when paired with MasterflexLive’s electronic signature and immutable event logging capabilities—fully traceable to user ID, timestamp, and action type.
Software & Data Management
The embedded firmware provides deterministic real-time control with ±0.1% speed resolution (0.1–250 rpm) and onboard storage for up to 50 named dispensing protocols. All operational parameters—including dispense volume, dwell time, ramp profiles, and sensor-triggered logic—are timestamped and exportable in CSV format. MasterflexLive serves as the centralized data hub: encrypted TLS 1.2 communication ensures secure transmission of telemetry to cloud-hosted dashboards, where trend analysis, SPC charting, and deviation reporting can be configured per batch or equipment ID. Audit trails comply with GLP/GMP documentation expectations, capturing all changes to calibration coefficients, user permissions, and firmware versions—including rollback capability for version verification.
Applications
This system is deployed in applications demanding metrological rigor and regulatory alignment: automated buffer preparation in upstream bioprocessing; fill-finish operations for diagnostic reagents and mRNA-LNP formulations; QC sample aliquoting in ISO 17025-accredited laboratories; and continuous-flow synthesis modules requiring precise stoichiometric delivery. Its low-shear performance makes it suitable for perfusion culture media exchange, viral vector concentration steps, and chromatography fraction collection where particulate generation or protein denaturation must be avoided. Integration readiness with MES and LIMS platforms enables full digital batch record generation aligned with Industry 4.0 infrastructure.
FAQ
What tubing sizes are supported with the Double-Y configuration?
L/S® sizes 13, 14, 16, 17, and 25 are validated for use with the Ultrapharm™ pump head in Double-Y orientation—each offering distinct pressure and flow trade-offs optimized for viscosity ranges from 1 to 10,000 cP.
Is the system compliant with 21 CFR Part 11 for electronic records?
Yes—when operated with MasterflexLive and configured with role-based authentication, audit trail logging, and electronic signatures, the system satisfies predicate rule requirements for electronic records and signatures in FDA-regulated environments.
Can the pump head undergo repeated autoclaving?
The optional 316L stainless steel pump head is validated for 10 full-cycle autoclave exposures (121°C, 15 psi, 30 min) without measurable drift in flow accuracy or tubing compression force.
How does the planetary drive improve dispensing repeatability?
Each roller is driven independently by the sun gear—eliminating differential slip between rollers and ensuring synchronized occlusion timing, which directly improves volumetric consistency and reduces coefficient of variation (CV) to <0.8% over 100 dispenses.
What is the maximum allowable inlet pressure?
The system is designed for gravity-fed or low-pressure (<2 psi) inlet conditions; backpressure exceeding 15 psi may compromise tubing seal integrity and volumetric accuracy—consult application engineering for pressurized feed configurations.
