Sartorius SECURA124-1CN Advanced Analytical Balance

Overview

The Sartorius SECURA124-1CN is a high-precision analytical balance engineered for laboratories requiring strict regulatory adherence, metrological integrity, and operational efficiency. Designed and manufactured in Germany, it operates on electromagnetic force compensation (EMFC) principle—ensuring stable, drift-free measurement performance across variable environmental conditions. With a maximum capacity of 120 g and readability of 0.1 mg (100 µg), the SECURA124-1CN meets the definition of a Class I analytical balance per OIML R 76 and satisfies the sensitivity and repeatability requirements outlined in USP for minimum weight determination. Its integrated LevelControl™ system continuously monitors and automatically corrects for tilt angles beyond ±0.5°, eliminating manual leveling errors and ensuring consistent measurement geometry—a critical factor for traceable mass determination under ISO/IEC 17025 accreditation.

Key Features

• LevelControl™ Active Leveling: Real-time sensor-based leveling with automatic motorized adjustment ensures optimal load cell alignment without user intervention.
• APC (Advanced Pharma Compliance): Embedded software module automates audit trail generation, user access control, electronic signature support, and configurable data retention—fully aligned with FDA 21 CFR Part 11 and EU Annex 11 requirements.
• Internal Calibration (isoCAL): Fully automated, temperature-compensated internal calibration routine triggered by time intervals, temperature shifts (>1.5 °C), or user command—validated per ISO 17025 calibration protocols.
• USP Minimum Weight Assurance: Built-in calculation engine validates sample mass against USP criteria using actual repeatability data—displaying pass/fail status and recommended minimum weight in real time.
• GLP/GMP-Ready Documentation: One-touch printing of fully traceable reports—including date/time stamp, operator ID, balance ID, calibration status, ambient conditions, and net/gross/tare values—compatible with Sartorius YDP30 thermal label or standard paper printers.
• Secure User Management: Role-based access control with password protection, multi-level permissions (operator, supervisor, administrator), and encrypted local storage of user logs.
• Hygienic Design: Seamless stainless-steel pan, smooth housing surfaces, and minimized crevices facilitate rapid cleaning and reduce cross-contamination risk—supporting ISO 14644 cleanroom compatibility assessments.

Sample Compatibility & Compliance

The SECURA124-1CN supports solid, granular, and low-viscosity liquid samples within its 120 g capacity range. Its draft shield (included as standard) features quick-release hinges and static-dissipative glass panels, minimizing electrostatic interference during microgram-scale weighing. The balance conforms to key international standards including ISO 9001, ISO/IEC 17025 (when used with certified weights and documented procedures), USP , , and , as well as GMP Annex 15 validation requirements. IQ/OQ documentation packages—including risk-based test protocols, acceptance criteria, and executed reports—are available upon request and pre-qualified for regulated pharmaceutical, biotech, and clinical research environments.

Software & Data Management

Data integrity is enforced through built-in audit trail functionality compliant with ALCOA+ principles (Attributable, Legible, Contemporaneous, Original, Accurate, Complete, Consistent, Enduring, Available). All critical events—including calibration, weighing, user login/logout, parameter changes, and error states—are timestamped and immutably logged. Export options include CSV and PDF formats via USB interface or optional Ethernet connectivity. When paired with Sartorius LabX software (sold separately), the SECURA124-1CN enables centralized instrument management, SOP-driven workflows, statistical process control (SPC), and full integration into LIMS or ERP systems.

Applications

This balance serves critical functions across quality control (QC), quality assurance (QA), and R&D settings: quantitative assay preparation in pharmaceutical formulation; reference standard weighing per ICH Q5C; gravimetric analysis in environmental testing labs; catalyst loading in fine chemical synthesis; residual solvent quantification; and stability-indicating method development. Its APC module is especially valuable in cGMP manufacturing units where batch record compliance, electronic signatures, and change control documentation are mandatory.

FAQ

Does the SECURA124-1CN support external calibration with traceable weights?
Yes—it accepts external calibration using Class E2 or better certified weights, with full documentation of calibration history stored locally.
Is the balance compatible with networked laboratory environments?
It supports USB host/device and optional Ethernet (via Sartorius Connect module) for seamless integration into LabX or third-party data systems.
What is the typical stabilization time after placing a sample?
Under standard lab conditions (20–25 °C, low air turbulence), stabilization is achieved in ≤1.5 seconds for most loads.
Can the balance be validated for GxP use out-of-the-box?
While factory-tested and supplied with basic IQ/OQ templates, formal validation requires site-specific execution per your organization’s validation master plan and applicable regulatory guidance.
How does LevelControl™ improve measurement reliability?
By maintaining consistent mechanical alignment of the load cell relative to gravity vector, LevelControl™ eliminates systematic bias introduced by surface inclination—directly improving long-term reproducibility and reducing uncertainty contributions from setup error.