NanoAerosol Generator Model 8050NM by Hope-Med

Overview

The NanoAerosol Generator Model 8050NM is a precision-engineered aerosol generation system designed for controlled production of monodisperse or narrowly distributed sub-100 nm particulate matter in laboratory and industrial hygiene settings. It operates on the principle of condensation aerosol generation—where vapor-phase precursors (e.g., diethylhexyl sebacate, DEHS, or ammonium sulfate) are thermally vaporized and subsequently cooled under controlled supersaturation conditions to nucleate nanoscale particles. The resulting aerosol exhibits a count median diameter (CMD) consistently below 100 nm, with ≥95% of particles falling within this size range—enabling rigorous validation of nanoparticle filtration media (e.g., N95/N99 respirators, ULPA filters), calibration of scanning mobility particle sizers (SMPS), and inhalation toxicology exposure studies per ISO 16890, EN 1822, and ASTM F2299.

Key Features

• Stable, continuous aerosol output with real-time concentration control via integrated mass flow controllers (MFCs) and temperature-regulated condensation chamber.
• Adjustable particle size distribution: optimized for CMD tuning between 20–100 nm through precise regulation of precursor vapor pressure, cooling rate, and dilution airflow.
• Robust stainless-steel construction with electropolished internal surfaces to minimize particle deposition and ensure long-term reproducibility.
• Integrated HEPA-filtered purge air supply and exhaust interface compatible with standard fume hoods or closed-loop exposure chambers.
• Compliance-ready design: supports IQ/OQ documentation packages and meets mechanical safety requirements per IEC 61000-6-2/6-3 for electromagnetic compatibility.

Sample Compatibility & Compliance

The 8050NM accommodates a broad range of volatile and semi-volatile precursors—including DEHS, dioctyl phthalate (DOP), polyalphaolefin (PAO), sodium chloride (NaCl), and ammonium sulfate—enabling generation of both organic and inorganic nanoscale aerosols. Its operation aligns with international test standards for filter certification (ISO 29463, EN 1822-3), respirator performance evaluation (NIOSH 42 CFR Part 84), and cleanroom challenge testing (ISO 14644-3). All fluidic pathways are chemically inert and validated for residue-free operation across repeated cycles. Device firmware logs operational parameters (temperature setpoints, MFC readings, run duration) with timestamping, supporting GLP-compliant record retention.

Software & Data Management

The generator operates in standalone mode or integrates via RS-485/Modbus RTU with external data acquisition systems. Optional PC-based control software provides graphical configuration of ramp profiles, automated sequence execution (e.g., multi-step size sweeps), and export of CSV-formatted logs containing time-synchronized concentration, temperature, and flow metrics. Audit trails include user login events, parameter changes, and system error codes—fully traceable for FDA 21 CFR Part 11–aligned environments when deployed with validated electronic signature modules.

Applications

• Performance validation of high-efficiency air filters (HEPA/ULPA) and personal protective equipment (PPE) against nanoparticles.
• Calibration and challenge testing of nanoparticle counters (CPCs), SMPS systems, and optical particle sizers (OPS).
• Controlled exposure studies in inhalation toxicology labs assessing pulmonary deposition and translocation of engineered nanomaterials.
• Development and verification of aerosol sampling methodologies per ISO/TC 229 standards for nanotechnology risk assessment.
• Environmental chamber conditioning for simulating urban or occupational ultrafine particle exposure scenarios.

FAQ

What precursor materials are compatible with the 8050NM?
DEHS, DOP, PAO, NaCl, ammonium sulfate, and other low-vapor-pressure compounds with thermal stability up to 300 °C.
Does the system require compressed gas or external vacuum sources?
No—integrated diaphragm pumps and regulated air supply eliminate dependency on facility gas lines or vacuum manifolds.
Can the 8050NM generate aerosols with geometric standard deviation (GSD) <1.3?
Yes; under optimized conditions with monodisperse seed aerosol injection, GSD as low as 1.15 is achievable for metrology-grade applications.
Is firmware update capability supported remotely?
Firmware updates are performed via USB drive with signed binaries; remote network access is disabled by default for security and regulatory compliance.
What documentation is provided for installation qualification (IQ)?
Standard delivery includes Factory Acceptance Test (FAT) report, mechanical drawings, electrical schematics, and a template-based IQ protocol aligned with ISO 9001 and GMP Annex 15 requirements.