Prefluid PF25 Modular Multi-Needle Peristaltic Filling System
| Brand | Prefluid |
|---|---|
| Origin | Jiangsu, China |
| Manufacturer Type | Authorized Distributor |
| Country of Origin | China |
| Model | PF25 |
| Pricing | Available Upon Request |
Overview
The Prefluid PF25 Modular Multi-Needle Peristaltic Filling System is a precision-engineered laboratory-scale liquid dispensing platform designed for high-reproducibility volumetric filling in regulated and research-intensive environments. Built upon a peristaltic pumping principle—where fluid is positively displaced by sequential compression of elastomeric tubing against a rigid housing—the PF25 delivers consistent, non-contact, contamination-free metering without valve wear or dead volume concerns. Its modular architecture enables scalable configurations from single-needle to multi-needle (up to 12 channels typical) operation, all centrally coordinated via an integrated touchscreen HMI and distributed servo-driven motor modules. The system is purpose-built for applications demanding traceable, repeatable micro-to-milliliter dispense volumes under GLP-compliant workflows, including R&D batch preparation, clinical assay kit assembly, and pre-formulation studies.
Key Features
- Fully stainless-steel pump heads (AISI 316L compliant), chemically resistant, smooth-surface finish for rapid cleaning and validation compliance
- Dual-roller alternating occlusion design ensures laminar flow profile, minimizing pulsation and achieving ≤±0.5% volumetric repeatability (at nominal flow rates)
- Vertical pump head mounting with kinematic linkage between upper pressure block and housing—enabling one-hand tube replacement without tooling or realignment
- Pre-friction soft-start algorithm reduces initial tube deformation stress, extending tubing service life by up to 40% compared to conventional ramp profiles
- Modular driver architecture: each needle channel operates via an independent DC servo motor module with encoder feedback, supporting synchronized or staggered dispensing sequences
- Integrated control cabinet includes industrial-grade switching power supply, embedded motion controller with real-time Ethernet/IP interface, and protocol gateway for Modbus TCP and RS-485 integration
- Touchscreen HMI (7″ capacitive LCD) supports recipe storage, audit trail logging (user login, parameter changes, run history), and configurable alarm thresholds per channel
Sample Compatibility & Compliance
The PF25 accommodates standard peristaltic tubing materials including PharmPure® silicone (USP Class VI), Tygon® LFL, and Viton®-lined variants—validated for aqueous buffers, organic solvents (≤30% ethanol), and low-viscosity diagnostic reagents (viscosity range: 0.8–20 cP). All wetted surfaces comply with ISO 10993-5 cytotoxicity requirements and meet FDA-recommended material biocompatibility guidelines for pharmaceutical contact surfaces. The system’s firmware architecture supports 21 CFR Part 11-ready configuration (electronic signatures, audit trail export, role-based access control) when deployed with validated software version ≥v2.3. Mechanical design adheres to IEC 61000-6-2/6-4 EMC standards and IP54-rated enclosures for laboratory ambient use.
Software & Data Management
The embedded controller runs a deterministic real-time OS with deterministic servo loop timing (<1 ms jitter). Dispense parameters—including target volume, flow rate ramp profile, dwell time, and tube inner diameter—are stored as encrypted binary recipes with SHA-256 checksums. Audit logs record timestamped events: operator ID, parameter modifications, start/stop commands, and fault codes (e.g., “tube slip detected”, “motor stall timeout”). Data export is supported via USB 2.0 mass storage or Ethernet file transfer (CSV/JSON format), compatible with LIMS integration through configurable RESTful API endpoints. Optional cloud synchronization enables remote monitoring and centralized fleet management across multiple PF25 units.
Applications
- Aseptic water-for-injection (WFI) vial filling during early-phase stability studies
- Multi-analyte diagnostic reagent dispensing into microtiter plates (96-/384-well) with inter-channel volume consistency <±0.8%
- Cryoprotectant solution dosing for lyophilization cycle development—maintaining thermal stability during low-flow-rate dispensing (0.1–5 mL/min)
- Cell culture media supplementation in bioprocess R&D, where sterility assurance and shear-sensitive component integrity are critical
- Calibration standard preparation for analytical instrumentation (HPLC, GC), requiring traceable volume accuracy per ISO/IEC 17025 clause 5.9
FAQ
What tubing sizes are supported by the PF25 pump head?
Standard configurations accept inner diameters from 0.5 mm to 3.2 mm (1/16″ to 1/8″), with optional custom mandrel sets available for specialized tubing geometries.
Can the PF25 be integrated into an automated fill-finish line?
Yes—the system provides dry-contact I/O signals (start/stop, ready, fault) and EtherNet/IP connectivity for PLC-level coordination with cappers, labelers, or conveyor systems.
Is validation documentation provided?
Factory-issued IQ/OQ protocols, material certificates (EN 10204 3.1), and electrical safety test reports (IEC 61010-1) are included; PQ support packages available upon request.
How is calibration traceability maintained?
Each unit ships with NIST-traceable gravimetric verification report (per ASTM D3231), and built-in auto-zero function compensates for tubing creep over extended operation cycles.
