Longer TS-1B Four-Channel Independent Control Syringe Pump

Overview

The Longer TS-1B is a precision-engineered four-channel independent control syringe pump system designed for demanding laboratory applications requiring synchronized yet fully decoupled fluid delivery across multiple lines. Based on high-resolution linear stepper motor actuation and closed-loop positional feedback, the TS-1B operates on the principle of precise plunger displacement control—translating commanded linear motion into volumetric flow via user-defined or preloaded syringe geometry. Its modular architecture separates the central controller from up to four physically independent actuators (W0109-1B), enabling flexible mounting in confined spaces, custom rack integration, or distributed experimental setups such as microfluidic chip interfaces, multi-reagent dosing systems, or parallel reaction monitoring. Unlike fixed-integrated pumps, the TS-1B’s distributed design supports heterogeneous syringe configurations per channel—allowing simultaneous use of 1 mL, 10 mL, and 60 mL glass or plastic syringes without cross-channel calibration interference. The system meets fundamental requirements for reproducible, traceable liquid handling in research-grade environments, with intrinsic compliance readiness for GLP-aligned workflows through parameter logging, state retention, and deterministic execution.

Key Features

• Fully independent channel control: Each of the four W0109-1B actuators accepts individual parameter sets—including flow direction, volume, timing, and operational mode—without interdependence.
• Five programmable operation modes per channel: Infuse only, withdraw only, infuse-then-withdraw, withdraw-then-infuse, and continuous cyclic operation.
• Sub-micron positional resolution: 0.165 µm stroke resolution ensures high-fidelity low-flow accuracy, critical for nanoliter-scale dispensing in cell culture, electrophysiology, or analytical sample introduction.
• Wide dynamic linear speed range: 7.94 µm/min to 79.4 mm/min enables seamless transition from ultra-slow perfusion (e.g., organ-on-chip media exchange) to rapid reagent loading (e.g., HPLC mobile phase priming).
• Comprehensive safety and fault management: Integrated stall detection triggers audible alarm and immediate halt upon mechanical obstruction; adjustable mechanical end-stop limits prevent syringe barrel deformation or plunger disengagement.
• Dual OC-gate status outputs per channel: Provide TTL-compatible signals indicating real-time run/stop state and infusion/withdrawal direction—enabling hardware-level synchronization with external devices (e.g., spectrometers, cameras, or PLCs).
• RS485 serial interface with ASCII protocol: Supports remote configuration, real-time monitoring, and script-driven batch operation via host PC or industrial controller, facilitating integration into automated lab platforms.

Sample Compatibility & Compliance

The TS-1B accommodates standard Luer-lock and Luer-slip syringes from major manufacturers (BD, Hamilton, SGE, etc.), with built-in database support for over 30 common models ranging from 0.5 mL to 60 mL capacity. Users may define up to four custom syringe inner diameters per channel, enabling accurate flow calculation even with non-standard or modified barrels. While not certified to IEC 61010-1 or ISO 13485 out-of-box, the system’s deterministic behavior, parameter persistence (including power-loss recovery), and audit-ready operational logs align with foundational requirements for method validation under ISO/IEC 17025 and internal SOP frameworks. Its RS485 interface supports timestamped command logging—a prerequisite for basic 21 CFR Part 11 compliance when paired with validated third-party software and access-controlled network infrastructure.

Software & Data Management

The TS-1B operates natively via its front-panel interface with bilingual (English/Chinese) firmware (TS-1B-B variant supplied with English UI). For advanced automation, the RS485 port allows bidirectional communication using standard Modbus RTU or proprietary ASCII command sets. Host-side applications can log all parameter changes, runtime states, and executed volumes with millisecond timestamp resolution. Critical functions—including parameter cloning across channels, delayed start scheduling, and multi-step sequence definition—are accessible via serial commands, enabling integration into Python-, LabVIEW-, or MATLAB-driven experimental pipelines. All settings—including syringe ID, inner diameter, flow profile, and delay offsets—are stored non-volatilely in controller memory, surviving power cycles without manual reconfiguration.

Applications

• Multi-stream microfluidic control: Independent regulation of sheath, sample, and buffer flows in droplet generation or laminar mixing devices.
• Automated titration and reagent addition: Precise stoichiometric delivery across parallel reaction vessels in combinatorial chemistry or catalyst screening.
• Chronic perfusion systems: Long-duration, low-flow nutrient or drug delivery in 3D tissue culture or organoid maintenance platforms.
• Calibration and standard preparation: Accurate dilution series generation for ICP-MS, LC-MS, or UV-Vis spectroscopy reference standards.
• Electrophysiology and patch-clamp rigs: Controlled pressure or solution exchange near recording electrodes with minimal mechanical vibration.
• Environmental simulation chambers: Coordinated humidification, CO₂ enrichment, and nutrient dosing in controlled-atmosphere growth studies.

FAQ

Can the TS-1B operate without a computer?
Yes—the controller includes a full-function keypad and LCD display, supporting standalone setup and execution of all four channels.
Is flow rate calibration required for each syringe?
While factory-calibrated linear motion ensures positional accuracy, volumetric accuracy depends on precise syringe inner diameter input; users are advised to perform one-time flow verification using gravimetric or timed-collect methods for critical applications.
Does the system support analog input for external flow modulation?
No—the TS-1B accepts only digital TTL or RS485 commands; analog voltage-based speed control is not implemented.
What is the maximum allowable backpressure for continuous operation?
Rated push force exceeds 90 N; actual pressure tolerance depends on syringe type and tubing configuration—typical safe operating limit is ≤2 MPa for standard glass syringes with rigid PTFE or stainless-steel tubing.
Can I synchronize start/stop across all channels with sub-second precision?
Yes—via RS485 broadcast command or front-panel “All Start” function; inherent latency between channels is <10 ms under nominal conditions.