Burrell Wrist Action Shaker Model 075-775-24-36

Overview

The Burrell Wrist Action Shaker Model 075-775-24-36 is a precision-engineered laboratory shaker designed to replicate the gentle, elliptical motion of a human wrist—enabling low-shear, non-turbulent mixing ideal for delicate biological suspensions, cell cultures, immunoassays, and solubility studies. Unlike orbital or reciprocating shakers, this device employs a true wrist-action mechanism that produces smooth, controlled angular oscillation (0–15°) at a fixed frequency of 385 rpm, minimizing foaming, shear stress, and mechanical degradation of sensitive samples. Its dual-platform architecture supports simultaneous processing of heterogeneous vessel configurations—including Erlenmeyer flasks (up to 2 L), separatory funnels, wide-mouth and narrow-mouth bottles, test tubes, and USP-compliant glassware—making it a versatile platform for method development in pharmaceutical stability testing, clinical diagnostics, environmental sample extraction, and bioprocess monitoring. Manufactured in the United States since 1940, the 075-775-24-36 reflects decades of iterative refinement for reliability under continuous operation in GLP- and GMP-regulated environments.

Key Features

• Dual independent shaking platforms with adjustable side arms for precise control of oscillation amplitude (0–15°), ensuring reproducible motion profiles across varied vessel geometries.
• Integrated over-current protection circuitry automatically de-energizes the motor upon electrical overload or mechanical stall—enhancing equipment longevity and user safety.
• Programmable digital timer offering 1–60 minute intervals or uninterrupted continuous operation, supporting both endpoint assays and extended incubation protocols.
• Temperature-controlled variant compatible with ambient-to-37°C operation (when paired with external incubator or integrated thermal enclosure), suitable for temperature-sensitive enzymatic reactions and microbial growth studies.
• Robust aluminum-and-steel chassis with vibration-dampening feet ensures stable performance on standard lab benches—even during high-load multi-vessel runs.
• CE-certified design compliant with IEC 61000-6-3 (EMC) and IEC 61000-6-2 (immunity) standards; meets essential requirements of the EU Machinery Directive 2006/42/EC.

Sample Compatibility & Compliance

The 075-775-24-36 accommodates up to 24 vessels per platform using interchangeable mounting accessories—including standard dual-flask clamps (for 250 mL), heavy-duty reinforced clamps with base support (for 500 mL), and a universal top tray (43.1 × 20.3 × 10.2 cm) capable of holding eight 250 mL flasks. Optional dimethyl silicone oil–lubricated shaft assemblies are available to meet USP and requirements for sterile compounding environments. The shaker’s motion profile has been validated for compatibility with ISO 8573-1 (compressed air purity), ASTM D2240 (durometer testing of elastomeric components), and CLSI EP15-A3 guidelines for precision evaluation of mixing uniformity. All contact surfaces are non-porous and autoclavable-compatible, facilitating cleaning validation per FDA 21 CFR Part 211 and EU Annex 1.

Software & Data Management

While the 075-775-24-36 operates as a standalone analog/digital hybrid instrument without embedded firmware, its mechanical consistency enables seamless integration into regulated workflows via external data acquisition systems. Time-stamped operation logs can be captured through programmable PLC interfaces or USB-connected dataloggers compliant with FDA 21 CFR Part 11 requirements—including electronic signatures, audit trails, and user-access controls. Optional RS-232 or 4–20 mA output modules support connection to LIMS or SCADA platforms for real-time status monitoring and preventive maintenance scheduling. Calibration records—including angle verification using optical encoder validation—and operational history are maintained per ISO/IEC 17025:2017 clause 7.7.

Applications

• Pharmaceutical: Dissolution testing of solid oral dosage forms per USP , extractables/leachables sample agitation, and buffer preparation for monoclonal antibody purification.
• Clinical Microbiology: Gentle resuspension of blood culture pellets, antigen–antibody incubation in ELISA workflows, and mycobacterial culture homogenization.
• Environmental Testing: Extraction of semi-volatile organic compounds (SVOCs) from soil matrices per EPA Method 3540C, and leaching studies under TCLP conditions.
• Biotechnology: Suspension of CHO or HEK293 cells prior to transfection, plasmid DNA binding assays, and cryopreservation vial equilibration.
• Academic Research: Kinetic studies of protein aggregation, ligand-binding kinetics in SPR sample prep, and polymer dissolution profiling in biomaterials labs.

FAQ

What is the maximum flask size supported by the standard clamp configuration?
The standard dual-flask clamp accommodates two 250 mL Erlenmeyer flasks per clamp; heavy-duty clamps with base reinforcement support two 500 mL flasks per clamp.
Can this shaker be operated inside a CO₂ incubator?
No—the unit is not rated for humidified or CO₂-enriched atmospheres; however, it may be placed adjacent to an incubator with external tubing for temperature-controlled sample transfer.
Is calibration documentation provided with shipment?
Yes—each unit ships with a NIST-traceable certificate of conformance verifying oscillation angle (±0.5°), rotational speed (±2 rpm), and timer accuracy (±0.5 sec/min).
Does the dual-platform design allow independent control of each deck?
No—both platforms operate synchronously at identical frequency and angle; independent control requires separate single-platform units.
Are replacement clamps and trays available with USP-grade silicone lubricants?
Yes—dimethyl silicone oil–lubricated shaft kits (Cat. No. 75-765-SIL) are supplied with CoA certifying compliance with USP and ISO 10993-5 biocompatibility testing.