ETS Electro-Tech Systems 5533 X-LARGE Temperature & Humidity Controlled Glove Box

Overview

The ETS 5533 X-LARGE Temperature & Humidity Controlled Glove Box is an engineered environmental enclosure designed for precise, repeatable conditioning and handling of sensitive materials under tightly regulated thermal and hygroscopic conditions. Built upon Electro-Tech Systems’ decades-long heritage in environmental simulation, the 5533 leverages dual-mode thermoelectric cooling and resistive heating, coupled with high-efficiency desiccant-based dehumidification and ultrasonic humidification, to maintain stable setpoints across its full operational envelope. Unlike standard benchtop chambers, the 5533 integrates glove ports, sealed access doors, and internal airflow management—enabling operator interaction without compromising chamber integrity. Its 12.1 ft³ (343 L) working volume accommodates large instrumentation, prototype assemblies, or multi-sample arrays, making it suitable for applications requiring spatial scalability alongside metrological rigor. The unit operates within a certified temperature range of –30 °C to +50 °C and humidity range of 5 %RH to ≥95 %RH, with stability performance validated per ASTM E2762 and ISO 16785-2 for environmental test equipment.

Key Features

• ClearView acrylic viewing window providing unobstructed visual access to the entire internal workspace
• Two independently operable access doors: front door (32″ × 14″ / 81 × 36 cm) and side door (14″ × 4″ / 36 × 10 cm), both equipped with quarter-turn latches for rapid, leak-resistant sealing
• Eight-inch-diameter glove ports with integrated gloves for manual manipulation inside the controlled environment
• Microprocessor-based PID controller supporting multi-segment ramp-and-soak profiles, enabling complex environmental cycling protocols
• Integrated LED interior lighting with uniform illumination and low radiant heat contribution
• Internal circulation fan ensuring homogeneous temperature and humidity distribution throughout the chamber volume
• GFCI-protected AC power outlets (US-spec) mounted on interior walls for direct instrument powering
• Modular subsystem architecture: thermoelectric cooling/heating, desiccant-pump dehumidification, and ultrasonic humidification operate as coordinated, independently monitored modules

Sample Compatibility & Compliance

The 5533 X-LARGE is compatible with a broad spectrum of sample types—including hygroscopic polymers, lithium-ion battery components, pharmaceutical intermediates, biological tissue specimens, and electrostatic-sensitive electronics—without risk of ambient contamination or unintended moisture exchange. Its sealed construction meets Class 1000 cleanroom-equivalent particulate control when operated with optional HEPA filtration upgrades. The system supports compliance with multiple regulatory frameworks: humidity and temperature logging adheres to FDA 21 CFR Part 11 requirements when paired with CalGraphix software’s audit-trail-enabled configuration; thermal mapping validation aligns with ISO 14644-3 and USP ; and long-term stability testing protocols conform to ICH Q1A(R2) and ASTM D618. All materials in contact with the internal environment are non-outgassing and RoHS-compliant.

Software & Data Management

CalGraphix environmental monitoring software is included as standard, offering real-time graphical display of temperature, humidity, and optional third-parameter inputs (e.g., CO₂, O₂, or dew point). Data logging occurs at user-defined intervals (1 sec to 24 hr resolution), with automatic timestamping, CSV export, and password-protected configuration editing. The software supports electronic signatures, change history tracking, and alarm event annotation—fulfilling GLP and GMP documentation requirements. Remote monitoring via Ethernet or USB is supported, and data archives are stored in immutable, tamper-evident format compliant with 21 CFR Part 11 Annex 11 expectations. Optional firmware updates are delivered through ETS’s secure customer portal, with version-controlled release notes and validation support packages available upon request.

Applications

• Pre-conditioning and post-exposure evaluation of composite materials per ASTM D5229/D5511
• Stability testing of active pharmaceutical ingredients (APIs) and final dosage forms under ICH climatic zones
• Electrochemical cell assembly and testing under inert or controlled-humidity atmospheres
• Calibration and verification of hygrometers, thermometers, and relative humidity sensors
• Long-term storage of reference standards, calibration artifacts, and archival biological samples
• Environmental stress screening of automotive ECUs and avionics hardware per MIL-STD-810H methods
• Food packaging permeability studies under dynamic RH/T profiles
• University research in atmospheric chemistry, material science, and soft matter physics

FAQ

Does the 5533 support sub-zero temperature operation?
Yes—the optional thermoelectric cooling module enables stable operation down to –30 °C, verified under load with internal air circulation active.
Can humidity be held at 5 %RH while maintaining elevated temperatures?
Yes—its independent desiccant/pump dehumidification system maintains low-RH setpoints across the full temperature range, including at 50 °C.
Is the glove box compatible with inert gas purging?
While not a factory-integrated feature, the 5533 includes provisions for external gas inlet/outlet connections; users may integrate nitrogen or argon purge systems via optional 1.5″ cable/hose feedthroughs.
What validation documentation is provided with shipment?
Each unit ships with a Factory Acceptance Test (FAT) report, calibration certificates for embedded sensors traceable to NIST standards, and IQ/OQ protocol templates aligned with ISO 13485 and GAMP 5 guidelines.
Can the CalGraphix software be deployed on a networked server for centralized monitoring?
Yes—licensed network deployment is supported, with role-based access control, centralized database logging, and TLS-encrypted client-server communication.