Shanghai Youyi LRH-100CL Low-Temperature Incubator

Overview

The Shanghai Youyi LRH-100CL Low-Temperature Incubator is an engineered environmental chamber designed for precise, stable thermal control across a wide operational range—from cryogenic storage at −40 °C to elevated incubation at +65 °C. Built upon a dual-mode thermal architecture combining high-efficiency compressor refrigeration with PID-regulated heating, the unit maintains strict temperature fidelity under dynamic load conditions. Its primary function is to support long-term sample integrity in life science workflows where thermal stability directly impacts biological activity, chemical stability, or material behavior. Unlike general-purpose cold rooms or ultra-low freezers, the LRH-100CL integrates incubation-grade air circulation, programmable ramp/soak profiles, and robust data logging—making it suitable not only for passive storage (e.g., serum, vaccines, lyophilized reagents) but also for active low-temperature cultivation (e.g., psychrophilic microorganisms), accelerated stability testing per ICH Q1 guidelines, and controlled environment qualification per ISO 14644-3 cleanroom protocols.

Key Features

• Stainless steel interior chamber with seamless, radius-cornered construction for enhanced cleanability and corrosion resistance—compliant with ISO 13485 cleanroom-compatible surface finish standards;
• Double-glazed, low-emissivity inner door with vacuum-insulated perimeter seal, minimizing radiant heat transfer and enabling real-time visual monitoring without thermal disturbance;
• Microprocessor-based temperature controller with 5.7-inch TFT-LCD interface; supports simultaneous display of setpoint, actual chamber temperature, elapsed time, and remaining hold duration;
• Adaptive airflow system featuring a branded centrifugal blower and asymmetric duct geometry—validated to achieve ≤±0.5 °C spatial uniformity (measured per ASTM E2874 Annex A2 at 9 locations across working volume);
• Non-volatile memory with auto-recovery logic: retains all user-defined parameters—including ramp rates, dwell times, alarm thresholds—after power interruption or controller reset;
• Eco-conscious refrigerant blend (R134a/R406a) compliant with Montreal Protocol Phase-Out Schedule and EU F-Gas Regulation (EC) No 517/2014;
• Modular chassis with dual mobility system: four swivel casters (two lockable) plus adjustable leveling feet for vibration-isolated placement on laboratory benches or dedicated floor stands.

Sample Compatibility & Compliance

The LRH-100CL accommodates standard laboratory consumables including 50 mL conical tubes, 15 mL Falcon tubes, Petri dishes (up to 150 mm diameter), multi-well plates (96-/384-well), and glass vials (2–20 mL). Its interior dimensions (450 × 380 × 590 mm) permit stacking of up to two standard ISO 8573-1 Class 4 compliant shelf racks (included), each supporting ≥15 kg static load. The unit meets electrical safety requirements per IEC 61010-1:2010 (Ed. 3.0) and electromagnetic compatibility per IEC 61326-1:2020. Optional accessories—including RS485/USB communication modules, embedded thermal printers, and independent overtemperature cut-off units—enable full traceability and alignment with FDA 21 CFR Part 11 electronic record requirements when integrated with validated LIMS or ELN platforms.

Software & Data Management

Standard firmware supports local parameter configuration, real-time trend logging (internal memory stores ≥30 days of 1-minute interval data), and configurable alarm outputs (audible buzzer + relay dry contact). When equipped with the optional USB/RS485 interface module, the incubator exports timestamped CSV-formatted temperature logs compatible with JMP, MATLAB, or LabArchives. The included PC software enables remote calibration verification, audit trail generation (user ID, action timestamp, pre/post-value), and export of PDF reports conforming to GLP Annex 11 and ISO/IEC 17025 clause 7.7 documentation requirements. Firmware updates are performed via secure signed binary upload, preserving cryptographic integrity of control algorithms.

Applications

• Long-term biobanking of human serum, plasma, and PBMCs at −40 °C under CLIA-certified storage conditions;
• Controlled-temperature stability studies for pharmaceutical intermediates per ICH Q5C guidelines;
• Cultivation of cold-adapted bacterial strains (e.g., Pseudomonas syringae, Colwellia psychrerythraea) requiring sub-zero growth kinetics;
• Accelerated aging tests for polymer-based medical devices per ISO 11607-1 Annex B;
• Low-temperature validation of diagnostic assay reagents during shelf-life extension programs;
• Environmental simulation for electronics reliability testing per MIL-STD-810H Method 502.7 (low-temperature operation).

FAQ

What is the minimum operating temperature and how is it sustained?
The LRH-100CL achieves and holds −40 °C using a cascade-capable single-stage compressor system with R134a/R406a mixed-refrigerant charge. Sustained operation at this setpoint requires ambient room temperature ≤25 °C and relative humidity ≤60% RH.

Does the unit support GMP-compliant data integrity?
Yes—when configured with the optional RS485 interface and validated software package, it provides electronic signatures, audit trails, and role-based access control aligned with FDA 21 CFR Part 11 Subpart C.

Can the incubator be integrated into a central building management system (BMS)?
Via the RS485 Modbus RTU protocol (optional), the unit transmits real-time temperature, status flags, and alarm events to third-party SCADA or BMS platforms using standard register mapping (0x0001–0x000F).

Is calibration certificate included with shipment?
A factory-issued NIST-traceable calibration report (covering three-point verification at −40 °C, 25 °C, and 65 °C) is provided. On-site IQ/OQ documentation packages are available upon request.