Shanghai RightOne LHS-1000CB Low-Temperature Temperature and Humidity Controlled Chamber

Overview

The Shanghai RightOne LHS-1000CB is an upright, air-cooled temperature and humidity controlled chamber engineered for long-term stability and precise environmental simulation across demanding laboratory and industrial applications. Designed around a dual-loop microcomputer PID control architecture, the chamber maintains tightly regulated thermal and hygroscopic conditions within its 1000 L stainless-steel working chamber (1000 × 1000 × 1000 mm). Its operational envelope spans −20 °C to +80 °C with ±0.5 °C temperature uniformity and 30–95 % RH humidity range with ±3 % RH deviation—validated under no-load, vibration-free, non-magnetic ambient conditions at 20 °C and 50 % RH. The system employs R134a/R406a eco-friendly refrigerants and integrates a self-designed electric heating tube humidification system with a built-in water reservoir, ensuring stable vapor generation without external plumbing. Its thermodynamic performance is enhanced by an optimized air duct structure supporting uniform convective circulation, minimizing spatial gradients critical for biological storage, material aging, and stability testing.

Key Features

• Upright configuration with castor-mounted base (four swivel casters + independent locking leveling feet) for flexible positioning and secure immobilization.
• Mirror-finish 304 stainless-steel interior with radius-rounded corners and adjustable multi-position shelving (standard: 3 shelves; max: 25 shelves) for ease of cleaning and customizable load distribution.
• Dual-pane insulated door assembly incorporating tempered glass with silicone-gasketed perimeter seal—preserves internal climate integrity during visual inspection.
• 5.7-inch high-contrast LCD interface with intuitive menu navigation and real-time display of setpoints, actual values, program status, and alarm logs.
• Advanced programmable controller supporting up to 99 multi-step cycles, each comprising up to 30 segments (max duration per segment: 99 h 99 min), enabling complex ramp-soak-hold profiles for ICH Q1, ASTM D4332, or ISO 188 protocols.
• Integrated humidity sensing using calibrated international-brand capacitive RH sensors and feedback-controlled resistive humidification—ensuring traceable moisture delivery and minimal hysteresis.

Sample Compatibility & Compliance

The LHS-1000CB accommodates diverse sample types including cryopreserved plasma units, vaccine vials, cell culture flasks, polymer specimens, electronic components, and pharmaceutical reference standards. Its validated operating envelope meets baseline requirements for long-term stability studies per ICH Q5C and accelerated testing per ICH Q1A(R2). While not pre-certified to GLP or GMP, the unit supports audit-ready operation when paired with optional accessories: USB/RS485 data logging interfaces (with timestamped CSV export), embedded thermal printer (for hard-copy record retention), and independent overtemperature alarm module (IEC 61000-4-2 compliant). Humidity control adheres to ASTM E104–22 methodology for saturated salt solution verification; temperature mapping per ISO/IEC 17025–recommended practices is achievable using external calibrated probes.

Software & Data Management

The embedded controller provides local parameter configuration, real-time trend visualization, and event-triggered alarm logging (e.g., door open, sensor fault, deviation exceedance). Optional communication modules enable bidirectional integration with laboratory information management systems (LIMS) or SCADA platforms via Modbus RTU or ASCII protocol. Data export supports time-stamped CSV files compatible with Microsoft Excel, MATLAB, or JMP for statistical process control (SPC) analysis. When configured with FDA 21 CFR Part 11-compliant software (sold separately), the system supports electronic signatures, audit trails, and role-based access control—satisfying regulatory documentation requirements for clinical trial material storage and QC release testing environments.

Applications

• Bio-banking: Extended storage of human plasma, serum, and tissue samples at clinically defined sub-zero temperatures (−20 °C) while maintaining humidity to prevent desiccation.
• Vaccine logistics: Stability monitoring of cold-chain sensitive formulations under variable RH conditions mimicking regional climatic stressors.
• Materials science: Accelerated aging of elastomers, adhesives, and packaging films per ASTM D3045 or ISO 4892–2.
• Electronics reliability: Thermal cycling and damp heat exposure per JEDEC JESD22-A110 and IEC 60068–2–78.
• Pharmaceutical development: Bracketing and matrixing studies for registration batches in accordance with ICH Q5C and WHO TRS 1011 Annex 9.

FAQ

What is the maximum allowable ambient temperature for continuous operation?
The chamber is rated for use in environments ≤30 °C and ≤70 % RH (non-condensing); operation beyond these limits may compromise cooling capacity and humidity control accuracy.
Can the unit be validated for GxP compliance?
Yes—when equipped with optional data logging hardware, calibrated external sensors, and appropriate IQ/OQ documentation packages, it supports qualification per ASTM E2500 and EU Annex 15 guidelines.
Is remote monitoring supported out-of-the-box?
No—remote supervision requires the optional RS485/USB interface module and third-party SCADA or custom Python-based polling scripts.
What maintenance intervals are recommended?
Compressor oil and refrigerant levels should be verified annually; condenser coils require biweekly vacuum cleaning; humidity reservoir and tubing must be descaled quarterly using 5 % citric acid solution.
Does the chamber support nitrogen purging?
Not natively—the standard configuration lacks gas inlet/outlet ports; however, 25 mm and 50 mm test ports (optional add-ons) permit integration with inert gas manifolds for oxygen-sensitive applications.