Shanghai Youyi LHS-500CL Low-Temperature Temperature and Humidity Controlled Chamber

Overview

The Shanghai Youyi LHS-500CL is a precision-engineered upright environmental test chamber designed for stable, long-term temperature and humidity control across an extended low-temperature range (−40 °C to +80 °C). Built on a robust air-cooled refrigeration architecture with R134a/R406a eco-friendly refrigerants, it delivers high thermal efficiency and low energy consumption while meeting international environmental compliance standards (e.g., Montreal Protocol Annex A Group II). Its operational principle relies on a microprocessor-controlled PID feedback loop governing both refrigeration compression cycles and resistive steam-generation humidification—ensuring dynamic equilibrium between heat exchange, moisture delivery, and airflow distribution. The chamber is widely deployed in GxP-regulated environments—including clinical laboratories, biobanks, vaccine stability testing facilities, and materials science R&D labs—where strict adherence to ICH Q5C, ISO 14644-1 (cleanroom-class air handling), and ASTM E2807 (environmental chamber performance verification) is required.

Key Features

• 5.7-inch high-resolution LCD touchscreen interface with intuitive menu navigation and real-time multi-parameter display (temperature, humidity, setpoint, elapsed time, program stage)
• Double-door structure with tempered glass observation window and silicone-gasketed seal, minimizing thermal leakage during visual inspection
• Electropolished mirror-finish stainless steel interior with radius-rounded corners (R ≥ 25 mm) for enhanced cleanability and corrosion resistance per ISO 15223-1
• Adjustable stainless steel shelving system (standard: 3 shelves; max capacity: 25 trays) supporting uniform load distribution up to 15 kg/shelf
• Patented forced-air convection ductwork ensuring ≤±0.5 °C spatial temperature uniformity (measured at 9-point grid per ASTM E742)
• Integrated water reservoir with submerged tubular heating elements and calibrated capacitive humidity sensor (Vaisala HUMICAP®-compatible) delivering ±3 % RH accuracy across full operating range
• Four-position castor system (two swivel + two lockable fixed feet) enabling safe repositioning on level laboratory flooring (load capacity: 300 kg)

Sample Compatibility & Compliance

The LHS-500CL accommodates a broad spectrum of sample types—including cryopreserved biological specimens (plasma, PBMCs, tissue sections), pharmaceutical reference standards, polymer films, electronic components, and accelerated aging test coupons. Its interior volume (500 L net) and 700 × 700 × 1020 mm usable workspace allow for stacked tray configurations without compromising airflow integrity. All materials in contact with the chamber environment comply with USP Class VI biocompatibility requirements. The unit supports GLP/GMP audit readiness through optional RS485/USB data logging interfaces (with timestamped CSV export), configurable alarm thresholds (high/low temp/humidity, door open, compressor fault), and programmable event-triggered notifications. It meets CE marking requirements under Directive 2014/30/EU (EMC) and 2014/35/EU (LVD), and its thermal insulation conforms to ISO 8502-2 for thermal bridging mitigation.

Software & Data Management

The embedded controller supports up to 99 programmable cycles, each comprising 30 segments with individual ramp rates, dwell times (up to 99 h 99 min), and setpoint transitions. Optional communication modules enable integration into centralized lab infrastructure via Modbus RTU or TCP/IP protocols. When paired with the dedicated PC software (supplied separately), users gain access to real-time remote monitoring, historical trend analysis, deviation reporting, and electronic signature-capable audit trails compliant with FDA 21 CFR Part 11 Annex 11 requirements. Raw data files include metadata headers indicating instrument ID, operator login, calibration status, and environmental validation certificates.

Applications

• Vaccine and biologics stability studies per ICH Q5C and WHO TRS 992 Annex 9
• Cryogenic storage simulation for blood banking and cord blood repositories
• Accelerated aging tests for medical device packaging (ISO 11607-1)
• Environmental stress screening of PCB assemblies (JEDEC JESD22-A108)
• Long-term hygrothermal conditioning of composite materials (ASTM D5229/D5511)
• Controlled humidity exposure for pharmaceutical excipient characterization (USP <1151>)

FAQ

What is the minimum achievable temperature with full humidity control active?
At 30 % RH, the chamber reliably maintains −40 °C; below 30 % RH, frost formation may limit sustained operation—consult technical specifications for dehumidification derating curves.
Is the unit suitable for continuous unattended operation over 72 hours?
Yes—equipped with redundant safety cutoffs (independent mechanical high-limit thermostat, compressor overheat protection, and door-open detection), validated for 168-hour uninterrupted runs under ISO 17025-accredited test conditions.
Can the internal shelves be removed for oversized sample loading?
All shelves are fully detachable; removal does not compromise airflow uniformity due to the chamber’s optimized vertical duct layout and baffle-guided circulation path.
Does the controller support custom alarm escalation protocols?
Via optional Ethernet module and configuration software, users can define multi-level notification chains (email/SMS) tied to specific parameter breaches, including configurable hysteresis and delay timers.
What calibration documentation is provided with shipment?
Each unit ships with a factory-as-tested certificate traceable to NIM (National Institute of Metrology, China) standards, covering temperature uniformity, humidity accuracy, and ramp rate linearity at three load conditions (empty, 50 %, full).