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| Brand | Unchained Labs |
|---|---|
| Origin | USA |
| Model | Leprechaun |
| Application | Single-particle immuno-structural analysis of lentiviral vectors and extracellular vesicles (e.g., exosomes) |
| Detection Principle | Fluorescence-based single-particle imaging coupled with antibody- and probe-mediated orthogonal labeling |
| Sensitivity | ≥1 × 10⁷ particles/mL |
| Particle Sizing Range | ~30–200 nm (diameter) |
| Capture Flexibility | Compatible with anti-VSV-G, anti-gp70, or user-provided custom capture antibodies |
| Nucleic Acid Detection | RNA-specific fluorescent probes (e.g., Quasar 670-labeled oligos) |
| Structural Discrimination | Simultaneous detection of capsid protein (e.g., p24), envelope glycoprotein (e.g., VSV-G), and genomic RNA |
| Aggregation Assessment | Quantitative resolution of monodisperse virions vs. dimers, trimers, and higher-order aggregates |
| Regulatory Alignment | Designed to support process development under ICH Q5A(R2), USP <1043>, and FDA CMC guidance for gene therapy products |
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