Agilent 7500 ICP-MS (Second-hand)

Overview

The Agilent 7500 ICP-MS is a high-performance inductively coupled plasma mass spectrometer engineered for ultra-trace elemental analysis at sub-femtogram-per-gram detection levels. Operating on the principle of ionization in a high-temperature Ar plasma (~7,000 K), followed by mass separation via a quadrupole mass filter and detection using a secondary electron multiplier (SEM), the system delivers robust isotopic ratio precision, multi-element quantification across 75+ elements, and interference-resolved analysis through helium collision cell technology. Designed for laboratories requiring regulatory-grade data integrity—particularly in environmental monitoring, geochemical research, clinical trace metal testing, and semiconductor material purity assessment—the Agilent 7500 platform integrates stable RF plasma generation, low-noise ion optics, and real-time background subtraction algorithms to ensure high reproducibility and long-term measurement stability.

Key Features

• Quadrupole-based mass analyzer with mass range of 1–280 amu and 0.75 amu resolution (10% peak height)
• Helium-mode collision/reaction cell for effective removal of polyatomic interferences (e.g., ⁴⁰Ar¹⁶O⁺, ⁴⁰Ar⁴⁰Ar⁺) without compromising sensitivity
• Robust RF generator (27 MHz) with automatic impedance matching and plasma ignition diagnostics
• Dual-mode detector: Analog mode for high-intensity signals (>10⁶ cps) and pulse-counting mode for low-abundance isotopes (down to ~1 cps)
• Integrated autosampler compatibility (e.g., Agilent G1832A) supporting programmable rinse, wash, and calibration sequences
• Refurbishment includes full vacuum system inspection (turbo-molecular pump + backing pump), replacement of critical consumables (sample cones, skimmer cones, torch, injector), and recalibration against NIST-traceable standards

Sample Compatibility & Compliance

The Agilent 7500 accepts liquid samples introduced via concentric nebulizer and quartz cyclonic spray chamber, supporting aqueous matrices with total dissolved solids (TDS) ≤ 0.2%. It accommodates standard 13 mm or 16 mm borosilicate glass vials and is compatible with microflow nebulizers for reduced sample consumption. All refurbished units undergo comprehensive performance verification per Agilent’s original factory test protocol—including sensitivity (≥ 1 × 10⁹ cps/ppm for ²³⁸U), oxide ratio (¹⁶O¹⁶O⁺/²³⁸U⁺ < 2%), and doubly charged ion ratio (¹³⁸Ba²⁺/¹³⁸Ba⁺ < 3%). The system supports audit-ready operation under GLP and ISO/IEC 17025 environments; optional software configurations enable 21 CFR Part 11-compliant electronic signatures and audit trail logging.

Software & Data Management

Controlled via Agilent MassHunter Workstation Software (version B.08.00 or later), the system provides intuitive method setup, real-time signal monitoring, and automated QC checks (e.g., daily tuning, drift correction, internal standard normalization). Data files are stored in vendor-neutral .d format, exportable to CSV, Excel, or ASCII for third-party statistical analysis. MassHunter Quantitative Analysis module supports isotope dilution mass spectrometry (IDMS), standard addition, and multi-point calibration with weighting. All refurbished instruments ship with licensed software, validated installation packages, and documented IQ/OQ protocols aligned with laboratory validation requirements.

Applications

• Environmental: Detection of As, Cd, Pb, Hg, U, and rare earth elements (REEs) in drinking water, wastewater, and soil extracts per EPA Methods 200.8 and 6020B
• Geochemistry: Precise isotopic ratio determination (e.g., ⁸⁷Sr/⁸⁶Sr, ¹⁴³Nd/¹⁴⁴Nd) in rock digests and mineral solutions
• Pharmaceutical & Biotech: Elemental impurity screening in drug substances and excipients per ICH Q3D guidelines
• Materials Science: Trace contaminant profiling in high-purity silicon, lithium battery cathodes, and photovoltaic-grade metals
• Clinical Research: Quantification of essential and toxic metals (e.g., Zn, Cu, Se, Tl) in serum, urine, and whole blood

FAQ

Is this instrument fully refurbished and performance-verified?
Yes. Each unit undergoes complete disassembly, cleaning, replacement of wear-prone components (cones, torch, pump oils), vacuum integrity testing, and full calibration using certified reference materials (CRMs) such as NIST SRM 3100 series.
Does it include original Agilent documentation and software licenses?
Yes. All systems ship with electronic copies of the user manual, safety guide, and maintenance logbook. A valid MassHunter license (perpetual or term-based) is included and pre-activated.
Can it be integrated into an existing LIMS environment?
Yes. MassHunter supports ODBC and ASTM E1384-compliant data export. Custom API integration is available via Agilent’s OpenLab CDS or third-party middleware.
What warranty and technical support are provided?
A 12-month parts-and-labor warranty is included. Remote diagnostics and application support are available through certified Agilent-trained engineers during business hours (EST). On-site service contracts can be arranged separately.
Are consumables and spare parts still available?
All critical consumables—including Ni and Pt sample/skimmer cones, alumina torches, and nebulizers—are currently stocked by Agilent and major OEM distributors globally. No end-of-life notices have been issued for the 7500 platform.