Analytik Jena InnuPure C16 touch Fully Automated Nucleic Acid Extraction System

Overview

The Analytik Jena InnuPure C16 touch is a benchtop fully automated nucleic acid purification system engineered for precision, reproducibility, and operational simplicity in molecular biology laboratories. It implements magnetic bead–based solid-phase extraction under programmable thermal and magnetic control, enabling consistent isolation of high-integrity DNA and RNA from diverse biological matrices—including whole blood, cultured cells, formalin-fixed paraffin-embedded (FFPE) tissues, bacterial cultures, viral lysates, forensic swabs, stool, and processed food samples. The instrument operates on the principle of paramagnetic particle binding in optimized buffer environments—leveraging Analytik Jena’s proprietary Dual Chemistry (DC) Technology—to achieve efficient lysis, selective nucleic acid binding, stringent wash steps, and low-volume elution without high-salt carryover. Optional Smart Extraction reagent kits eliminate solid-phase media entirely, relying instead on tip-based homogenization and phase separation to yield nucleic acids directly compatible with downstream enzymatic applications such as PCR, qPCR, NGS library preparation, and restriction digestion.

Key Features

• Integrated Intelligent Heating/Magnet Unit (IHMU): Combines precise temperature control (4–95 °C) with dynamic magnetic field generation to ensure uniform bead dispersion during binding and rapid pellet formation during wash/elution steps.
• 10-inch capacitive touchscreen interface with IPextract OS: Enables standalone operation—no external PC required—with preloaded, protocol-optimized extraction methods for over 30 sample types and kit formats.
• Single-use, pre-aliquoted, foil-sealed reagent strips or 16-well plates: Eliminates manual pipetting, reduces human error, prevents cross-contamination between runs, and ensures reagent stability and lot-to-lot consistency.
• Filter-tip pipetting (1000 µL capacity): Minimizes aerosol-mediated carryover; tip penetration function avoids membrane tearing during reagent access.
• UV-C sterilization module (254 nm): Automatically activates between runs to decontaminate internal surfaces and reduce residual nucleic acid carryover.
• Full enclosure during operation: Sealed front door maintains laminar airflow integrity and prevents environmental particulate ingress.

Sample Compatibility & Compliance

The InnuPure C16 touch accommodates a broad spectrum of input materials—from viscous whole blood and fibrous plant tissue to low-abundance cell-free DNA in plasma. Its hardware and DC-Technology–optimized chemistries support ISO 18385–compliant forensic sample processing, ASTM D7917–aligned environmental DNA workflows, and USP –informed biobanking protocols. While not certified as an IVD device, the system is routinely deployed in clinical research labs operating under CAP/CLIA-equivalent quality frameworks. When used with validated reagent kits and documented SOPs, it meets traceability requirements for GLP studies per OECD Principles and supports 21 CFR Part 11–compliant electronic records when paired with third-party audit-trail software.

Software & Data Management

IPextract OS provides intuitive method selection, real-time run monitoring, and comprehensive log export (CSV/Excel). All extraction protocols are version-controlled and updated free of charge for the instrument’s lifetime. Barcode scanning via USB-connected scanner enables sample-level metadata capture—including donor ID, collection date, and kit lot number—for full chain-of-custody documentation. Exported logs include timestamps, temperature/magnet actuation profiles, tip usage history, and error codes—facilitating root-cause analysis during QA/QC review or regulatory inspection.

Applications

This system serves core functions across academic, diagnostic, pharmaceutical, and food safety laboratories: high-yield genomic DNA isolation for CRISPR editing validation; intact total RNA recovery from degraded FFPE sections for transcriptome profiling; pathogen nucleic acid enrichment from complex stool matrices for metagenomic sequencing; and rapid viral RNA purification from nasopharyngeal swabs in outbreak response settings. Its compatibility with both magnetic bead–based and Smart Extraction chemistries allows flexible adoption across evolving assay development pipelines—particularly where salt-sensitive downstream applications (e.g., single-cell RNA-seq or long-read sequencing) demand ultra-low ionic residue.

FAQ

Does the InnuPure C16 touch require a dedicated computer or network connection?

No—it operates independently via its built-in touchscreen and onboard OS. Network connectivity is optional and only needed for remote log backup or barcode integration.

Can I use third-party reagents or custom protocols?

The system is validated exclusively with Analytik Jena–branded kits. While open protocol mode exists, deviation from certified chemistries voids performance guarantees and may compromise reproducibility.

How is carryover contamination prevented between runs?

Through a multi-layered strategy: UV-C irradiation, filter-tip aspiration, sealed reagent packaging, non-contact tip penetration, and full enclosure during processing.

What maintenance is required beyond routine cleaning?

Annual calibration of heating and magnetic modules is recommended; no user-serviceable parts require replacement under normal usage conditions.

Is the system compliant with FDA 21 CFR Part 11?

The hardware and firmware support audit-trail functionality, but full Part 11 compliance requires integration with a validated electronic lab notebook (ELN) or LIMS that enforces electronic signatures, role-based access, and immutable record retention.