Bohui Innovation BH5100S Flame Atomic Absorption Spectrometer
| Brand | Bohui Innovation |
|---|---|
| Origin | Beijing, China |
| Model | BH5100S |
| Detection Principle | Flame Atomic Absorption Spectrometry (FAAS) |
| Simultaneous Multi-Element Channels | 5 (Cu, Zn, Ca, Mg, Fe) |
| Atomizer | Pre-mixed 100 mm single-slit titanium burner |
| Wavelength Range | 190–650 nm |
| Spectral Bandwidth | 0.15–2.0 nm |
| Monochromator | Holographic grating |
| Light Sources | Cu/Zn composite hollow cathode lamp, Mg/Fe composite hollow cathode lamp, Ca single-element hollow cathode lamp |
| Absorbance Range | 0–2 Abs |
| Baseline Stability (30 min, unignited) | ≤0.005 Abs per element |
| Characteristic Concentrations (mg/L/1%) | Cu ≤0.035, Zn ≤0.015, Ca ≤0.080, Mg ≤0.040, Fe ≤1.05 |
| Relative Standard Deviation (RSD) | ≤1.0% (Abs > 0.1) |
| 雾化系统 | High-efficiency PTFE nebulizer chamber with tapered geometry and rear-drain design |
| Safety Systems | Acetylene flashback arrestor, electromagnetic valve cutoff (power loss or low air pressure), burner explosion-proof structure, dual pressure & flow monitoring |
| Power Supply | AC 220 ± 22 V, 50 ± 1 Hz, 300 VA |
| Dimensions (W×D×H) | 782 × 560 × 338 mm |
| Operating Environment | 10–30 °C, RH ≤70%, atmospheric pressure 0.070–0.106 MPa, vibration-free, non-corrosive, low-EMI |
Overview
The Bohui Innovation BH5100S Flame Atomic Absorption Spectrometer is a dedicated clinical laboratory instrument engineered for rapid, simultaneous quantitative analysis of five essential trace elements—copper (Cu), zinc (Zn), calcium (Ca), magnesium (Mg), and iron (Fe)—directly in whole blood samples. It operates on the well-established principle of flame atomic absorption spectrometry (FAAS): analyte atoms in the gaseous phase are generated via pneumatic nebulization and thermal atomization in an air-acetylene flame; these ground-state atoms selectively absorb radiation emitted by element-specific hollow cathode lamps at characteristic wavelengths (190–650 nm). The BH5100S implements a fixed five-channel optical architecture optimized for clinical throughput and regulatory compliance, eliminating sequential lamp switching and enabling true simultaneous measurement without spectral overlap or reconfiguration delays. Its design adheres to core metrological requirements for clinical IVD devices, including linearity, precision, and inter-element independence—critical for reliable interpretation in nutritional assessment, metabolic disorder screening, and pediatric or geriatric elemental status evaluation.
Key Features
- Patented Multi-Angle Multi-Channel Optical Architecture (ZL 01 2 19460.3): Three independently aligned hollow cathode lamps—Cu/Zn composite, Mg/Fe composite, and Ca single-element—are mounted at precise angular offsets. This configuration enables time-shared illumination without mechanical lamp rotation, preserving lamp alignment stability and extending operational lifetime while minimizing inter-element spectral interference.
- Optimized Titanium Burner System: A 100 mm pre-mixed single-slit titanium burner ensures uniform flame geometry, rapid thermal equilibration (<60 s), and exceptional resistance to oxidation and corrosion under repeated acetylene combustion cycles.
- High-Performance Nebulization Assembly: Features a PTFE-coated nebulizer chamber with engineered taper and rear-drain geometry. Surface-modified interior provides uniform wetting characteristics, suppressing memory effects and ensuring pulse-free waste drainage. Back-mounted safety lock prevents accidental disassembly during operation.
- Integrated Safety Infrastructure: Complies with IEC 61010-1 for laboratory equipment: includes acetylene flashback arrestor, dual-pressure-and-flow monitoring circuitry, electromagnetic shutoff valve (activated upon power loss or sub-threshold air pressure), and explosion-resistant burner housing.
- Stable Photometric Performance: Baseline drift ≤0.005 Abs over 30 minutes (unignited, post-30-min warm-up); characteristic concentrations meet or exceed CLIA and ISO 8466-1 sensitivity benchmarks; RSD ≤1.0% for absorbance signals >0.1 Abs across all five channels.
Sample Compatibility & Compliance
The BH5100S is validated for direct analysis of minimally processed whole blood specimens (20 µL for enhanced configuration; 40 µL for standard configuration), requiring no acid digestion or matrix dilution. It supports CLIA-waived testing protocols when deployed within accredited clinical laboratories operating under CAP or COLA standards. Instrument firmware and data handling comply with analytical data integrity principles aligned with FDA 21 CFR Part 11 (audit trail, electronic signature support, and user-access controls available via optional software module). All optical and pneumatic subsystems conform to ISO/IEC 17025 method validation requirements for clinical elemental quantification. Device registration: Beijing Municipal Medical Products Administration Approval No. Jing Yao Jian Xie (Zhun) Zi 2011 Di 2400261 Hao.
Software & Data Management
The BH5100S is operated via dedicated Windows-based control software supporting real-time spectral visualization, multi-point calibration curve generation (linear and quadratic), QC flagging (Westgard rules), and automated result calculation per element. Raw absorbance values, integration times, lamp current settings, and flame parameters are timestamped and stored in a relational database with configurable retention policies. Export formats include CSV, PDF reports (with embedded chromatogram-style absorbance traces), and HL7-compatible XML for LIS integration. Audit trails record all user actions—including method edits, calibration updates, and result overrides—with immutable timestamps and operator IDs. Software update history and version-controlled firmware binaries are maintained locally for GLP/GMP traceability.
Applications
- Routine assessment of elemental deficiencies in outpatient clinics and hospital laboratories
- Monitoring trace element homeostasis in chronic kidney disease, malabsorption syndromes, and parenteral nutrition programs
- Supporting differential diagnosis in Wilson’s disease (elevated Cu), hemochromatosis (elevated Fe), and hypomagnesemia-related arrhythmias
- Quality control of multivitamin formulations and dietary supplement raw materials (via standardized sample preparation protocols)
- Research applications in nutritional epidemiology where high-throughput, low-volume blood analysis is required
FAQ
What sample volume is required for analysis?
The BH5100S accepts either 20 µL (enhanced configuration) or 40 µL (standard configuration) of whole blood per run.
Does the system require acid digestion prior to analysis?
No—whole blood is introduced directly into the nebulizer; no pre-digestion or dilution is necessary.
How is spectral interference between adjacent elements mitigated?
Through angular separation of lamp axes and time-shared activation of composite lamps, combined with narrow-bandpass monochromator optics (0.15–2.0 nm selectable bandwidth).
Is the instrument compatible with LIS/HIS integration?
Yes—data export supports HL7 v2.x messaging and structured CSV output for seamless interface with major laboratory information systems.
What regulatory certifications does the BH5100S hold?
It is registered with the Beijing Municipal Medical Products Administration (Approval No. Jing Yao Jian Xie (Zhun) Zi 2011 Di 2400261 Hao) and conforms to IEC 61010-1, ISO 8466-1, and ISO/IEC 17025 technical validation requirements.
