Brookfield 560TP Tissue Tensile Tester
| Origin | USA |
|---|---|
| Manufacturer Type | Authorized Distributor |
| Origin Category | Imported |
| Model | 560TP |
| Pricing | Upon Request |
Overview
The Brookfield 560TP Tissue Tensile Tester is a benchtop mechanical testing system engineered for quantitative assessment of uniaxial tensile properties in excised biological soft tissues. It operates on the fundamental principle of controlled-force or controlled-displacement uniaxial extension, applying calibrated linear tension to mounted specimens while recording load–displacement data in real time. Designed specifically for preclinical and translational physiology laboratories, the 560TP delivers repeatable, traceable mechanical characterization of vascular segments (e.g., murine aorta, carotid artery), skeletal or cardiac muscle strips, ligaments, tendons, and other compliant biomaterials under isothermal, ex vivo conditions. Its modular fixture architecture enables rapid adaptation across tissue geometries without recalibration, supporting standardized biomechanical protocols aligned with ASTM F2193 (Standard Practice for Mechanical Testing of Vascular Grafts) and ISO 7198 (Cardiovascular implants – Vascular prostheses).
Key Features
- Compact, gravity-fed electromechanical actuation system with precision lead-screw drive and integrated load cell (full-scale range: 0–50 N, resolution: ≤0.01 N)
- Adjustable crosshead travel (0–100 mm) with digital position encoder (±1 µm repeatability)
- Modular specimen clamping system: interchangeable fixtures for ring-shaped vascular segments, rectangular muscle strips, and cylindrical tissue plugs
- Real-time force–displacement curve acquisition at up to 100 Hz sampling rate via USB 2.0 interface
- Integrated thermal stabilization platform (ambient temperature ±0.5 °C) to minimize viscoelastic drift during prolonged testing
- No external air supply or hydraulic components — fully self-contained operation compatible with standard laboratory power (100–240 VAC, 50/60 Hz)
Sample Compatibility & Compliance
The 560TP accommodates fresh, frozen-thawed, or chemically fixed specimens ranging from 2 mm to 15 mm in gauge length and 0.5 mm to 4 mm in cross-sectional dimension. Common applications include rat/mouse thoracic aorta, femoral artery, papillary muscle, diaphragm strips, and engineered tissue constructs. All mechanical outputs (stress, strain, elastic modulus, ultimate tensile strength, failure strain) are computed using user-defined cross-sectional area inputs and comply with GLP documentation requirements. Data files conform to ASTM E4 format for third-party audit readiness. The system supports integration into FDA 21 CFR Part 11–compliant workflows when paired with validated software modules and electronic signature controls.
Software & Data Management
The instrument is supplied with TensilePro v3.2 — a Windows-based application enabling protocol-driven test sequencing, real-time visualization, and automated parameter extraction (e.g., linear elastic region slope, yield point, rupture energy). Raw data exports as CSV and HDF5 formats; processed metrics are stored in encrypted SQLite databases with full audit trail logging (user ID, timestamp, parameter edits, calibration events). Optional API access allows bidirectional integration with LabVantage LIMS or MATLAB-based custom analysis pipelines. Software validation packages (IQ/OQ/PQ documentation) are available upon request for regulated environments.
Applications
- Characterization of arterial stiffening in hypertension and aging models
- Evaluation of pharmacological modulation of vascular tone (e.g., endothelin-1, acetylcholine, sodium nitroprusside responses)
- Mechanical phenotyping of genetically modified mouse strains (e.g., collagen IV knockout, elastin haploinsufficiency)
- Biomechanical validation of decellularized scaffolds and 3D-bioprinted vascular grafts
- Quality control of contractile function in isolated muscle preparations under varying Ca²⁺ concentrations or metabolic inhibitors
- Teaching laboratory use for undergraduate and graduate courses in cardiovascular physiology and tissue engineering
FAQ
What types of tissue samples can be tested on the 560TP?
Fresh, cryopreserved, or formalin-fixed vascular tissues (aorta, coronary, mesenteric arteries), skeletal/cardiac muscle strips, tendons, and synthetic hydrogels with Young’s moduli between 1 kPa and 5 MPa.
Is the system compliant with ISO 13485 or FDA QSR requirements?
The hardware meets ISO 14971 risk management principles; full QSR compliance requires site-specific validation of software, procedures, and operator training — documentation templates are provided.
Can the 560TP perform cyclic loading or stress-relaxation tests?
Yes — via programmable multi-step protocols in TensilePro, including ramp-hold cycles, sinusoidal waveforms (0.01–5 Hz), and creep sequences with user-defined dwell times.
Does the system require annual recalibration?
Load cell and position sensor calibrations are recommended annually per ISO/IEC 17025 guidelines; internal verification checks can be performed daily using certified reference weights and displacement gauges.
Is technical support available outside North America?
Yes — Brookfield maintains authorized service partners in Europe, APAC, and Latin America with remote diagnostics and on-site calibration capabilities.
