BUCHI E-800 / E-800 LSV Universal Solid-Liquid Extractor

Overview

The BUCHI E-800 and E-800 LSV Universal Solid-Liquid Extractors are precision-engineered, fully automated systems designed for regulatory-compliant solvent extraction of solid and semi-solid samples. Based on classical Soxhlet principles—coupled with advanced thermal management, programmable solvent cycling, and real-time process monitoring—the instruments support five standardized extraction methodologies: Standard Soxhlet, Hot Soxhlet, Hot Extraction (non-cycling), Continuous Extraction, and Twisselmann extraction. This versatility enables method transfer across diverse analytical workflows while maintaining full traceability and reproducibility. The system is purpose-built for laboratories requiring high-throughput, auditable fat, lipid, pesticide residue, contaminant, or active ingredient quantification in accordance with AOAC, ISO 1133, ISO 6496, USP , EPA Method 3540C, and EN 14083 standards.

Key Features

• Multi-method flexibility: Preconfigured protocols for Standard Soxhlet, Hot Soxhlet, Hot Extraction, Continuous Extraction, and Twisselmann extraction—each fully customizable via intuitive touchscreen interface.
• True Soxhlet cycle simulation: Solvent vaporization, condensation, siphoning, and automatic chamber refilling replicate classical Soxhlet thermodynamics without manual intervention or risk of overflow.
• Robust thermal architecture: Independent heating zones for extraction chamber and receiving flask ensure precise temperature control (30–400 °C) with ±1% accuracy; integrated overtemperature protection and vapor pressure monitoring prevent thermal degradation of labile analytes.
• Six-channel parallel operation: Enables simultaneous processing of up to six samples under identical or independently programmed conditions—maximizing throughput while preserving inter-run comparability.
• Comprehensive safety engineering: Hermetically sealed extraction manifold, integrated fume containment, motorized safety shield with interlocked access control, and real-time leak detection safeguard operator health and laboratory integrity.
• Modular scalability: E-800 LSV variant accommodates larger sample loads and higher solvent volumes (extraction chamber: 130–220 mL; receiving flask: 150–250 mL), supporting both routine QC and method development applications.

Sample Compatibility & Compliance

The E-800 series processes a broad spectrum of matrices—including foodstuffs, animal feed, environmental soils/sediments, pharmaceutical excipients, polymer additives, crude oil fractions, pulp and paper extracts, and textile fibers—without matrix-specific hardware modification. All extraction protocols adhere to Good Laboratory Practice (GLP) and Good Manufacturing Practice (GMP) requirements. Full audit trail generation—including user ID, timestamped parameter changes, alarm logs, and final report metadata—ensures compliance with FDA 21 CFR Part 11 and EU Annex 11 for electronic records and signatures. System validation documentation (IQ/OQ/PQ templates) and calibration certificates are provided per ICH Q2(R2) guidelines.

Software & Data Management

Operation is managed via a 10.1-inch capacitive touchscreen running BUCHI’s proprietary ExtractionControl™ software. The interface supports multi-language operation, drag-and-drop method building, and real-time visualization of temperature profiles, solvent level dynamics, and cycle progression. Remote monitoring and control are enabled through the BUCHI LabX® Mobile app (iOS/Android), allowing secure access to live status, historical run data, and PDF report generation from any network-connected device. Native integration with Laboratory Information Management Systems (LIMS) is achieved via ASTM E1384-compliant HL7 and CSV export protocols. All raw data—including sensor readings at 1-second intervals—are stored locally with SHA-256 hashing and optional encrypted cloud backup.

Applications

• Fat and crude lipid determination in dairy, meat, cereals, and infant formula per AOAC 991.36 and ISO 1444.
• Pesticide residue extraction from fruits, vegetables, and soil prior to GC-MS or LC-MS/MS analysis (EPA 3540C, EN 15662).
• Plasticizer and additive recovery from polymeric materials (e.g., phthalates from PVC, antioxidants from rubber) under ISO 17225 and DIN EN 14387.
• Active pharmaceutical ingredient (API) and botanical marker extraction from herbal powders and tablets (USP , Ph. Eur. 2.4.24).
• Hydrocarbon fractionation in petroleum products and lubricants (ASTM D2276, IP 176).
• Extractable and leachable (E&L) studies for medical device packaging and single-use bioprocessing components (ISO 10993-12, USP ).

FAQ

What extraction standards does the E-800 support out-of-the-box?
The instrument includes validated methods for AOAC 991.36 (fat), ISO 6496 (crude fat), EPA 3540C (Soxhlet), and EN 14083 (residues in feed), with additional protocols available via BUCHI Method Library updates.
Can the E-800 be integrated into an existing LIMS environment?
Yes—via standard HL7 v2.x messaging, RESTful API endpoints, and configurable CSV/XML export templates compliant with ASTM E1384 and ISO/IEC 17025 data exchange requirements.
Is the system suitable for thermally labile compounds?
Yes—programmable ramp rates, solvent boiling point compensation, and optional inert gas purging minimize thermal stress; method optimization tools allow empirical determination of minimal effective temperature and dwell time.
What safety certifications does the E-800 hold?
CE marked per Machinery Directive 2006/42/EC and Electromagnetic Compatibility Directive 2014/30/EU; conforms to IEC 61010-1:2010 for laboratory electrical equipment safety.
How is calibration and performance verification performed?
Built-in temperature sensor verification routines, gravimetric solvent delivery checks, and NIST-traceable reference material runs (e.g., certified fat standards) are supported; full IQ/OQ/PQ documentation kits are included with purchase.