Cole-Parmer Masterflex L/S Series Peristaltic Pump
| Brand | Cole-Parmer |
|---|---|
| Origin | USA |
| Manufacturer Type | Authorized Distributor |
| Product Category | Imported Laboratory Equipment |
| Model | L/S Series |
| Instrument Type | Peristaltic Pump |
| Flow Rate Range | 0.1–3400 mL/min |
| Speed Range | 0.1–600 rpm |
| Accuracy | ±0.1% (digital precision models) |
| Drive Options | Analog, Digital, Programmable, Bidirectional |
| Pump Head Configurations | Single- to Multi-Channel |
| Tubing Compatibility | Standard L/S-sized silicone, Viton®, Tygon®, C-Flex®, PharMed® BPT |
Overview
The Cole-Parmer Masterflex® L/S Series Peristaltic Pump is an engineered solution for precise, contamination-free fluid handling in regulated and research-intensive laboratory environments. Based on the fundamental principle of peristalsis—where rollers compress flexible tubing to generate positive displacement—the L/S platform delivers repeatable volumetric flow without exposing internal pump mechanisms to the process fluid. This design ensures full fluid path isolation, eliminating cross-contamination risks and simplifying validation for applications requiring strict adherence to Good Laboratory Practice (GLP), Good Manufacturing Practice (GMP), and FDA 21 CFR Part 11 compliance. The modular architecture integrates interchangeable pump heads, drive units, and chemically resistant tubing—enabling configuration scalability from low-flow analytical dosing (0.1 mL/min) to high-throughput transfer (3.4 L/min). Its robust brushless DC motor, precision-machined roller assemblies, and calibrated speed control deliver high reproducibility across extended operational cycles, making it suitable for continuous operation in bioprocessing, environmental sampling, pharmaceutical formulation, and academic research workflows.
Key Features
- Modular system architecture supporting over 20 L/S-compatible pump heads—including single-channel, multi-channel (up to 8 channels), and high-torque configurations for viscous or shear-sensitive fluids.
- Three drive classes: analog (manual knob control), digital (microprocessor-based speed regulation), and programmable (RS-232/USB interface with real-time flow calibration, ramp profiles, and event logging).
- Speed accuracy down to ±0.1% for digital precision models—validated per ASTM D5291 for repeatability in gravimetric flow testing.
- Comprehensive tubing compatibility with ISO 594-1 compliant L/S sizing (e.g., 13, 14, 16, 17, 24, 35, 36); supports autoclavable, USP Class VI-certified, and FDA-compliant elastomers including platinum-cured silicone, PharMed® BPT, and C-Flex®.
- Integrated thermal protection, stall detection, and emergency stop functionality aligned with IEC 61000-6-2 electromagnetic compatibility standards.
- Front-panel LED display with real-time RPM readout, directional indicator, and error code diagnostics for rapid troubleshooting.
Sample Compatibility & Compliance
The L/S Series accommodates a broad spectrum of liquid types—including aqueous buffers, organic solvents, cell culture media, acidic or alkaline reagents (pH 1–14), and sterile biologics—provided compatible tubing is selected. Tubing selection directly governs chemical resistance, pressure tolerance (up to 30 psi), and particulate shedding performance. All standard configurations comply with ISO 9001-certified manufacturing processes. When paired with validated tubing sets and documented calibration procedures, the system meets traceability requirements for ISO/IEC 17025-accredited laboratories. Optional IQ/OQ documentation packages support installation and operational qualification under GxP frameworks.
Software & Data Management
Digital and programmable drives support Cole-Parmer’s Masterflex Connect™ software (Windows-compatible), enabling remote parameter configuration, time-based flow scheduling, data export in CSV/Excel format, and audit-trail generation for critical operations. Firmware updates preserve backward compatibility with legacy L/S controllers. Data integrity safeguards include user-access levels, electronic signatures, and tamper-evident log files—fully aligned with FDA 21 CFR Part 11 Annex 11 expectations for electronic records and signatures.
Applications
- Continuous feed of nutrient media in bioreactors and fermenters
- Automated fraction collection in HPLC and FPLC systems
- Controlled dosing of reagents in automated titration and enzymatic assay platforms
- Waste removal and sampling in environmental monitoring stations
- Cell suspension perfusion in 3D tissue culture and organ-on-chip devices
- Low-shear transfer of shear-thinning polymer solutions and nanoparticle dispersions
FAQ
Can the L/S Series be integrated into a PLC-controlled automation system?
Yes—programmable models feature isolated digital I/O (start/stop, direction, fault output) and Modbus RTU over RS-485 for seamless integration with industrial control networks.
What is the maximum allowable backpressure for L/S pump heads?
Standard L/S pump heads are rated for continuous operation at up to 30 psi (2.1 bar); higher-pressure variants (e.g., L/S High-Pressure Head) support 60 psi with appropriate tubing selection.
Is tubing replacement required after each use in sterile applications?
Not inherently—autoclavable tubing (e.g., platinum-cured silicone) may be reused for multiple cycles if validated per internal SOPs; however, single-use tubing is recommended for aseptic processing where sterility assurance is non-negotiable.
How is flow rate calibrated and verified?
Calibration is performed gravimetrically using certified analytical balances and timed volumetric collection; Cole-Parmer provides NIST-traceable calibration certificates upon request, and Masterflex Connect™ supports user-defined calibration curves.
Does the drive unit support bidirectional operation across all models?
Bidirectional capability is standard on programmable and select digital drives (e.g., 77963-10); analog models (e.g., 77910-25) operate unidirectionally unless retrofitted with optional reverse kits.
