CS200 Precision Pulse and Current Stimulator
| Origin | USA |
|---|---|
| Manufacturer Type | Authorized Distributor |
| Origin Category | Imported |
| Model | CS200 |
| Pricing | Available Upon Request |
Overview
The CS200 Precision Pulse and Current Stimulator is a benchtop, microprocessor-controlled electrophysiological stimulation device engineered for high-fidelity, repeatable delivery of controlled electrical stimuli in research and preclinical laboratory settings. It operates on constant-current or constant-voltage output principles—user-selectable per protocol—and delivers biphasic, monophasic, or charge-balanced square-wave pulses with precise temporal resolution. Designed to meet the rigorous demands of neurophysiology, neuromuscular transmission studies, and autonomic nervous system investigations, the CS200 integrates seamlessly with physiological data acquisition systems (e.g., PowerLab, Spike2, Axon Digidata) via TTL synchronization and analog trigger inputs/outputs. Its architecture adheres to IEC 61010-1 safety standards for laboratory electrical equipment, ensuring compliance with international requirements for low-energy stimulation devices used in ex vivo and in vitro preparations.
Key Features
- Three programmable stimulation modes: single-pulse, continuous train (frequency-swept or fixed-frequency), and stepwise ramped protocols—optimized for dose–response characterization at neurovascular junctions and synaptic terminals.
- Adjustable pulse parameters: amplitude (0.1–100 mA constant-current or 0.1–100 V constant-voltage), pulse width (10 µs–2 s), inter-pulse interval (1 ms–999 s), and train duration (1–9999 pulses).
- Real-time LED status indicators for output activation, overload protection, and mode selection; tactile feedback buttons with backlighting for gloved-hand operation in dimmed electrophysiology rigs.
- Isolated output stage with <1 µA leakage current and galvanic isolation rated to 500 VDC, minimizing ground-loop artifacts and ensuring signal integrity during concurrent recording.
- Built-in safety interlocks including automatic current limiting, open-circuit detection, and thermal shutdown—certified to UL 61010-1 and CE-marked for use in Class II laboratory environments.
Sample Compatibility & Compliance
The CS200 is validated for use with isolated tissue preparations (e.g., rat sciatic nerve, mouse diaphragm, guinea pig ileum), brain slice recordings, and peripheral nerve cuff electrodes. It supports both submerged and air-interface configurations when paired with Faraday cages or grounded saline baths. All output channels comply with ISO 14155:2020 guidelines for non-clinical biocompatibility assessment of stimulation interfaces. While not intended for human use, its output characteristics align with ASTM F2182-22 (standard test method for measurement of radio-frequency-induced heating) benchmarks for electromagnetic compatibility in hybrid electrophysiology–MRI setups. Device firmware and calibration records support GLP-compliant audit trails when integrated into validated lab workflows.
Software & Data Management
Stimulation protocols are configured via front-panel controls or optional USB-connected configuration software (CS200 Control Suite v3.x), which enables batch protocol storage, timestamped event logging, and CSV export of stimulus metadata (pulse count, amplitude drift, trigger latency). The software supports integration with LabVIEW™ via shared memory buffers and provides SCPI-compatible command syntax for automated assay scripting. Audit logs include user ID, date/time stamps, parameter changes, and calibration verification events—fully traceable for FDA 21 CFR Part 11–aligned environments where electronic records are retained as primary data.
Applications
- Characterization of conduction velocity and refractory periods in myelinated and unmyelinated nerve fibers.
- Functional assessment of neuromuscular junctions using evoked endplate potentials in skeletal muscle preparations.
- Pharmacological screening of ion channel modulators (e.g., Nav, Kv, Cav) through stimulus–response curve generation.
- Vascular reactivity studies involving perivascular nerve stimulation in pressurized arteriole models.
- Validation of optogenetic actuators by co-delivering light pulses and precisely timed electrical triggers in dual-modality experiments.
FAQ
Is the CS200 suitable for in vivo animal studies?
Yes—when used with appropriate electrode configurations and under IACUC-approved protocols, the CS200 supports acute in vivo nerve stimulation in rodents and rabbits. Output isolation and low-noise design minimize artifact coupling during simultaneous EMG or LFP recording.
Does the device support arbitrary waveform generation?
No—the CS200 delivers only digitally synthesized square-wave pulses. Arbitrary waveform capability requires external function generators synchronized via TTL triggers.
What calibration interval is recommended?
Annual calibration against NIST-traceable current/voltage standards is advised; internal self-test routines verify output fidelity prior to each experimental session.
Can multiple CS200 units be synchronized?
Yes—using the master–slave TTL sync interface, up to four units can be phase-locked with sub-millisecond jitter for multi-site stimulation paradigms.
Is firmware upgrade support available?
Yes—field-upgradable firmware is distributed via secure portal access for registered institutions; version history and validation reports are provided per release.
