DLAB HC110-Pro Advanced Peltier-Driven Thermoelectric Metal Bath

Overview

The DLAB HC110-Pro is a high-performance, Peltier-based thermoelectric metal bath engineered for precise, bidirectional temperature control across a broad operational range—from sub-ambient cooling (–5 °C) to elevated heating (110 °C). Unlike conventional resistive-heating-only metal blocks, the HC110-Pro integrates solid-state thermoelectric modules enabling active cooling without external chillers or cryogenic fluids. Its compact aluminum alloy heating block ensures rapid thermal response and excellent heat distribution, with a verified uniformity of ±0.5 °C at 37 °C—a critical benchmark for enzymatic assays, nucleic acid hybridization, and cell culture sample equilibration. Designed for integration into regulated laboratory environments, the device complies with IEC 61010-1 safety standards for electrical equipment used in laboratory settings and supports traceable temperature validation protocols required under GLP and ISO/IEC 17025 frameworks.

Key Features

• Peltier-driven dual-mode control: Simultaneous heating and cooling capability eliminates dependency on external refrigeration units; achieves –5 °C within ambient conditions up to 30 °C.
• High-fidelity thermal regulation: PID-controlled feedback loop delivers ±0.5 °C accuracy over 20–45 °C and maintains stability <±0.3 °C over 8-hour continuous operation at setpoint.
• Magnetic module docking system: Tool-free, self-aligning interface enables instant recognition and thermal coupling between the instrument and interchangeable aluminum or stainless-steel blocks (e.g., 0.2 mL PCR, 1.5/2.0 mL microcentrifuge, 15/50 mL conical tube formats).
• User-configurable programming: Stores up to nine independent multi-step protocols—including ramp-hold-cool cycles—with time resolution down to 1 minute and temperature resolution of 0.1 °C.
• Onboard calibration utility: Allows end-user verification and adjustment of temperature sensor offset using NIST-traceable reference probes—supporting internal audit requirements per FDA 21 CFR Part 11 Annex 11 when paired with compliant data logging software.
• Integrated thermal lid: Removable insulated cover minimizes convective heat loss and improves energy efficiency by >35% during extended incubations at >60 °C.

Sample Compatibility & Compliance

The HC110-Pro accommodates standard laboratory consumables via drop-in modular inserts, including but not limited to 0.2 mL PCR strips, 1.5 mL and 2.0 mL microtubes, 15 mL and 50 mL conical tubes, and custom-designed deep-well plates. All contact surfaces are anodized aluminum or electropolished stainless steel, ensuring chemical resistance to common solvents (e.g., ethanol, isopropanol, diluted acids/bases) and compatibility with autoclaving (module-dependent). The instrument meets CE marking requirements (EMC Directive 2014/30/EU and LVD Directive 2014/35/EU), conforms to RoHS 2011/65/EU restrictions on hazardous substances, and operates within environmental specifications defined in ISO 15195:2018 for clinical laboratory temperature equipment validation.

Software & Data Management

While the HC110-Pro operates autonomously via its front-panel TFT interface, optional USB-to-serial connectivity enables integration with DLAB’s PC-based LabControl Suite (v3.2+). This software provides real-time temperature logging, export of timestamped CSV datasets, protocol synchronization across multiple units, and generation of IQ/OQ documentation templates aligned with USP Analytical Instrument Qualification guidelines. Audit trail functionality—including operator ID, parameter changes, and calibration events—is available when deployed under Windows domain authentication with write-protected log directories—fulfilling ALCOA+ data integrity principles for GxP-regulated workflows.

Applications

• Enzyme kinetics studies requiring tightly controlled sub-physiological temperatures (e.g., restriction digests at 16 °C or phosphatase inactivation at 65 °C)
• Thermal denaturation and renaturation of DNA/RNA in molecular biology workflows
• Pre-incubation of reagents for ELISA, lateral flow assays, and immunochemistry staining protocols
• Stabilization of temperature-sensitive enzymes, antibodies, and metabolites during sample preparation
• QC/QA testing of thermal stability in pharmaceutical excipients and biologics formulations
• Field-deployable sample conditioning in mobile labs and point-of-care diagnostic platforms due to low power draw (180 W max) and compact footprint (<2.5 L volume)

FAQ

Does the HC110-Pro require external coolant or compressed air for cooling?
No. It uses solid-state Peltier elements for active cooling; no external fluids, gases, or ventilation ducts are needed.

Can the temperature calibration be performed without service personnel?
Yes. The built-in calibration mode accepts input from a certified reference thermometer (e.g., Fluke 1523 or equivalent Class A Pt100 probe) and allows user-adjusted offset correction.

Is the device compatible with 24/7 unattended operation?
Yes. It features overtemperature and dry-run protection, automatic shutdown after timer expiration, and thermal cutoff at 115 °C block surface temperature.

What is the expected lifetime of the Peltier modules under continuous use?
Rated for >20,000 hours of cumulative operation under typical lab conditions (25 °C ambient, 50% duty cycle), consistent with MTBF specifications in IEC 62304 for Class B medical device software components.

Are third-party modules supported?
Only DLAB-certified modules are guaranteed for thermal performance and magnetic interface compatibility; non-OEM inserts may compromise temperature uniformity and void warranty coverage.