Great Wall CLZZ-30 Vacuum Filtration Apparatus

Overview

The Great Wall CLZZ-30 Vacuum Filtration Apparatus is a medium-scale, bench-to-pilot compatible solid–liquid separation system engineered for reproducible, visually monitored vacuum filtration under controlled low-pressure conditions. Based on the principle of pressure-driven filtration—where differential pressure across a porous fritted disc forces liquid phase through while retaining particulate solids—the CLZZ-30 integrates borosilicate glass 3.3 components with a mechanically robust SUS304 and anodized 6061-F aluminum frame. Its design supports both batch and semi-continuous operation in synthetic chemistry, pharmaceutical crystallization, catalyst recovery, and fine chemical purification workflows. The apparatus operates within a wide thermal envelope (−80 °C to +200 °C), enabling compatibility with cryogenic slurries, hot saturated solutions, and thermally sensitive precipitates. With a nominal filtration vessel capacity of 30 L and a 20 L collection flask, it bridges laboratory-scale development and early-stage process validation without requiring full-scale pilot infrastructure.

Key Features

• Transparent borosilicate glass 3.3 filtration vessel and receiver—enabling real-time observation of slurry behavior, cake formation, filtrate clarity, and potential channeling or cracking.
• SUS304 stainless steel structural frame combined with 6061-F aluminum panels finished with epoxy-based powder coating—providing corrosion resistance, dimensional stability, and mechanical rigidity under repeated vacuum cycling.
• Standard PTFE fritted disc (20–30 µm pore size) mounted on a quick-release support plate—ensuring chemical inertness, minimal extractables, and ease of removal for cleaning or replacement.
• Modular port configuration: 40# flanged inlet for controlled slurry charging; dual 24/29# standard taper ground joints for vacuum evacuation and venting—facilitating leak-tight connections with common lab vacuum manifolds and pressure-relief valves.
• Lockable, heavy-duty casters (two fixed, two swivel with brakes)—allowing stable positioning during operation and safe repositioning between fume hoods, gloveboxes, or drying stations.
• Full compliance with ISO 3585 specifications for borosilicate glass 3.3—including coefficient of thermal expansion (3.3 × 10⁻⁶ K⁻¹), hydrolytic resistance class HGB 1, and acid/alkali resistance per DIN 12116 and DIN 12117.

Sample Compatibility & Compliance

The CLZZ-30 accommodates heterogeneous mixtures containing organic solvents (e.g., THF, ethyl acetate, DMF), aqueous buffers, acidic or basic media (pH 1–13), and suspensions with particle sizes ranging from coarse precipitates (>100 µm) to fine colloidal aggregates (≥20 µm). Its PTFE frit and glass-wetted path eliminate metallic leaching and adsorption artifacts, supporting USP particulate matter testing preparation and ASTM E2932-compliant filtration validation. The apparatus meets general requirements for Good Laboratory Practice (GLP) environments when integrated into documented SOPs; optional traceable calibration records for vacuum gauges and temperature sensors are available upon request for GMP-aligned installations.

Software & Data Management

As a manually operated, non-automated vacuum filtration system, the CLZZ-30 does not include embedded controllers or digital interfaces. However, its standardized port geometry and pressure/temperature rating allow seamless integration with third-party vacuum controllers (e.g., Vacuubrand VRV, KNF N860), digital manometers (±0.1 mbar resolution), and data loggers compliant with FDA 21 CFR Part 11 when used in regulated environments. Process parameters—including applied vacuum level, filtration duration, slurry volume, and ambient temperature—can be recorded in electronic lab notebooks (ELNs) such as LabArchives or Benchling to support audit trails and batch documentation.

Applications

• Crystallization workup: Isolation of API intermediates and final active pharmaceutical ingredients following antisolvent addition or cooling crystallization.
• Heterogeneous catalysis: Recovery and washing of supported metal catalysts (e.g., Pd/C, Raney Ni) without mechanical degradation.
• Polymer synthesis: Removal of unreacted monomers, initiators, or crosslinking agents from reaction mixtures prior to precipitation or solvent exchange.
• Environmental sample processing: Solid-phase extraction of suspended solids from wastewater or soil leachates prior to ICP-MS or GC-MS analysis.
• Biotechnology: Clarification of cell lysates or fermentation broths when membrane filtration is unsuitable due to high viscosity or particulate load.

FAQ

What vacuum level can the CLZZ-30 sustain continuously?
The apparatus is rated for sustained operation at ≤ −0.098 MPa (equivalent to ~20 mbar absolute pressure) using a two-stage rotary vane or diaphragm vacuum pump with appropriate cold trap.
Is the PTFE frit replaceable with alternative porosities or materials?
Yes—custom frits (10–100 µm) in PTFE, sintered stainless steel, or glass are available as optional accessories; contact technical support for dimensional and sealing compatibility verification.
Can the CLZZ-30 be used under positive pressure?
No—the glass components are designed exclusively for vacuum or atmospheric pressure service; pressurized operation exceeds design limits and voids warranty.
Are spare parts such as ground-joint sleeves or O-rings available separately?
Yes—standardized Viton® and EPDM sealing kits, PTFE joint sleeves, and replacement frit holders are stocked and shipped globally with OEM part numbers.
Does the system comply with CE or UL safety directives?
The CLZZ-30 is supplied as a component-level apparatus without integrated electrical elements; final system-level CE/UL certification responsibility rests with the end-user’s qualified safety engineer upon integration into a complete vacuum manifold setup.