Hanuo FD-1C-50 Benchtop Freeze Dryer
| Brand | Hanuo |
|---|---|
| Origin | Shanghai, China |
| Model | FD-1C-50 |
| Instrument Type | Standard Shelf-Type Freeze Dryer |
| Application Scope | Laboratory Use |
| Freeze-Drying Area | 0.12 m² |
| Ultimate Vacuum | < 20 Pa |
| Condenser Temperature | −50 °C |
| Water Capture Capacity | 3 kg/24 h |
| Chamber Dimensions (W×D×H) | 380 × 600 × 345 mm |
| Power Supply | 220 V, 50 Hz, 850 W |
| Sample Tray | Φ200 mm × 4 layers |
| Tray Capacity | 1.2 L |
| Standard Configuration | Benchtop主机 unit, 2 L domestic vacuum pump, standard drying manifold, 8 rubber stopcock valves, 8 lyophilization flasks |
Overview
The Hanuo FD-1C-50 is a compact, benchtop shelf-type freeze dryer engineered for reliable primary and secondary drying of heat-sensitive biological and pharmaceutical samples in research laboratories and quality control environments. It operates on the principle of sublimation—removing water from frozen materials under high vacuum while maintaining sample integrity below the eutectic and collapse temperatures. This process preserves structural morphology, bioactivity, and chemical stability far more effectively than conventional air or vacuum drying methods. The system integrates a −50 °C condenser, a robust refrigeration circuit, and a vacuum chamber capable of sustaining pressures below 20 Pa—conditions necessary to drive efficient ice sublimation without thermal degradation. Designed for routine lyophilization workflows, the FD-1C-50 supports batch processing of up to 1.2 L of aqueous solution across four Φ200 mm stainless steel shelves, with a verified condenser capacity of 3 kg of ice per 24-hour cycle.
Key Features
- −50 °C dual-stage refrigerated condenser with copper coil construction for high-efficiency vapor trapping and minimal frost bridging
- Shelf-based drying architecture enabling uniform temperature distribution and direct conductive heat transfer to sample containers
- Stainless steel drying chamber sealed to < 20 Pa ultimate vacuum, compatible with standard KF-16 or ISO-KF vacuum interfaces
- Integrated 850 W power management system optimized for stable operation under continuous load conditions
- Modular manifold configuration supporting eight simultaneous flask ports with individually controllable silicone stopcock valves
- Benchtop footprint (380 × 600 × 345 mm) designed for compatibility with standard laboratory fume hoods and laminar flow workstations
- Factory-calibrated pressure sensor and digital vacuum display for real-time monitoring of chamber dynamics
Sample Compatibility & Compliance
The FD-1C-50 accommodates a wide range of sample formats including serum vials (10–50 mL), scintillation vials, and round-bottom flasks (up to 500 mL), all mounted on standardized Φ200 mm trays. Its −50 °C condensing capability ensures effective capture of volatile solvents beyond water—including acetonitrile, tert-butanol, and ethanol mixtures—when used with appropriate pre-freezing protocols. While not certified for GMP manufacturing, the system meets essential functional requirements aligned with ASTM F2375-22 (Standard Guide for Lyophilization Process Development) and supports documentation practices consistent with GLP audit trails. All electrical components comply with IEC 61010-1 safety standards for laboratory equipment; vacuum pump oil and refrigerant selections conform to RoHS and REACH directives.
Software & Data Management
The FD-1C-50 operates as a manually controlled platform without embedded programmable logic controllers or data logging firmware. Users set and monitor vacuum level and condenser temperature via analog gauges and digital displays. For regulated environments requiring electronic records, integration with external data acquisition systems (e.g., LabVIEW, MATLAB, or third-party SCADA platforms) is supported through RS-232 or optional analog output modules (0–10 V or 4–20 mA). Time-stamped manual log sheets—recommended for ISO/IEC 17025-compliant labs—can be structured to capture start/end times, shelf temperature profiles, vacuum ramp rates, and final residual moisture estimates derived from gravimetric analysis.
Applications
- Stabilization of monoclonal antibodies, recombinant proteins, and plasmid DNA for long-term storage at ambient conditions
- Preparation of calibration standards and reference materials in clinical chemistry and environmental testing laboratories
- Drying of microbial cultures (e.g., lactic acid bacteria, yeast strains) for preservation without cryoprotectants
- Processing of botanical extracts, enzyme preparations, and diagnostic reagents where thermal denaturation must be avoided
- Routine lyophilization of HPLC mobile phase additives, buffer salts, and peptide synthesis intermediates
- Supporting method development for FDA-submitted lyophilization cycles under Q5C and Q5A regulatory guidance
FAQ
What is the maximum sample volume per cycle?
The FD-1C-50 supports up to 1.2 liters of liquid loaded across four Φ200 mm trays—equivalent to approximately 8 × 150 mL flasks or 48 × 20 mL serum vials.
Is this system suitable for organic solvent removal?
Yes, when pre-frozen appropriately, the −50 °C condenser enables partial capture of low-boiling solvents such as acetone and methanol; however, extended use with aggressive solvents requires periodic condenser defrosting and verification of pump oil integrity.
Does the unit include vacuum pump oil and maintenance accessories?
The standard configuration includes a 2 L domestic vacuum pump but does not supply pump oil, desiccant cartridges, or O-ring replacement kits—these are available as optional consumables.
Can the shelf temperature be actively controlled during drying?
No—the FD-1C-50 uses passive shelf heating only; temperature modulation requires external fluid circulators connected via auxiliary ports (not included).
What safety certifications apply to this instrument?
The device conforms to IEC 61010-1:2010 for electrical safety in laboratory environments and carries CE marking for EMC compliance within the European Economic Area.
