Hanuo HNDK200-1 Dry-Block Nitrogen Evaporator

Overview

The Hanuo HNDK200-1 Dry-Block Nitrogen Evaporator is an engineered solution for parallel sample concentration in analytical laboratories requiring precise, reproducible, and oxygen-sensitive solvent removal. It operates on the principle of inert gas-assisted evaporation: nitrogen gas—delivered via adjustable stainless-steel needles—is directed tangentially across the surface of heated samples, accelerating solvent volatilization while minimizing oxidation, thermal degradation, or cross-contamination. Unlike rotary evaporation, which processes one or few samples sequentially, the HNDK200-1 enables simultaneous concentration of up to 12 samples under tightly controlled thermal and gaseous conditions. Its dry-block heating architecture eliminates oil bath maintenance, improves thermal uniformity across the heating surface, and ensures rapid heat-up (≤30 minutes from 40°C to 150°C) with minimal overshoot. Designed for integration into regulated workflows—including those aligned with GLP, ISO/IEC 17025, and FDA 21 CFR Part 11 requirements—the instrument supports traceable operation through real-time digital monitoring and built-in safety interlocks.

Key Features

• Dry-block heating system with aluminum alloy heating module for rapid thermal response and uniform temperature distribution (±0.5°C stability at 100°C)
• Individually controllable 12-channel nitrogen flow regulation—enabling selective activation per position to conserve gas and reduce operational cost
• Vertically adjustable gas manifold with height-synchronized needle positioning—accommodates varying solvent volumes and tube geometries without manual repositioning
• Modular, interchangeable heating blocks compatible with standard tube diameters (6–28 mm), microcentrifuge tubes (0.2–2.0 mL), 96-well plates, and custom fixtures (dimensions: 95.5 × 76.5 × 50 mm)
• Integrated over-temperature cutoff and self-diagnostic circuitry with audible alarm—compliant with IEC 61010-1 safety standards for laboratory equipment
• High-resolution LED display showing real-time temperature (0.1°C resolution), countdown timer (99 h 59 min max), and system status indicators
• Compact footprint (280 × 220 × 320 mm) and low power consumption (150 W)—suitable for benchtop use inside fume hoods or laminar flow cabinets when handling volatile or toxic solvents

Sample Compatibility & Compliance

The HNDK200-1 accommodates a broad range of sample containers—including 16 mm test tubes (standard configuration), 0.2–2.0 mL microcentrifuge tubes, 96-well PCR plates, and custom-fabricated holders—via its standardized modular block interface. Each block is precision-machined to ensure consistent thermal contact and mechanical stability during extended runs. The system meets essential electrical safety requirements per IEC 61010-1 and is suitable for use in environments adhering to ISO 15190 (laboratory safety) and ISO/IEC 17025 (competence of testing and calibration laboratories). While not inherently 21 CFR Part 11–certified, its digital logging capabilities (time-stamped temperature and timer values) support audit-ready documentation when paired with validated lab information management systems (LIMS) or electronic lab notebooks (ELN).

Software & Data Management

The HNDK200-1 operates as a standalone instrument with no embedded software or network connectivity. All operational parameters—including setpoint temperature, elapsed/concentration time, and real-time temperature—are displayed locally on the front-panel LED interface. For laboratories requiring data capture, external USB thermocouple loggers or RS-232-enabled data acquisition modules may be interfaced via optional analog output ports (available upon request). All user interactions are manually recorded; no electronic signature, audit trail, or user access control is implemented onboard—consistent with Class II non-critical laboratory instrumentation per GAMP 5 guidance.

Applications

• Routine concentration of extracts prior to LC-MS/MS, GC-MS, or HPLC analysis in environmental, pharmaceutical, and clinical toxicology labs
• Preparative cleanup in pesticide residue analysis (AOAC 2007.01, EN 15662) and mycotoxin quantification (ISO 17072-1)
• High-throughput sample prep for hormone profiling (e.g., cortisol, testosterone) in endocrinology research
• Stabilization of light- or oxygen-sensitive analytes—including retinoids, prostaglandins, and certain oligonucleotides—during solvent exchange
• Parallel evaporation in method development workflows where reproducibility across replicates is critical (e.g., recovery studies, matrix effect evaluation)

FAQ

Is the HNDK200-1 compatible with corrosive solvents such as chloroform or DCM?
Yes—provided the instrument is operated inside a certified fume hood and the gas needles are regularly inspected for corrosion. Aluminum heating blocks exhibit moderate resistance to halogenated solvents; prolonged exposure is not recommended without periodic cleaning and passivation.

Can the unit be used without nitrogen gas supply?
No. The HNDK200-1 requires a regulated nitrogen source (0–10 L/min, ≤0.1 MPa). Ambient air is not a substitute due to oxidation risk and uncontrolled humidity.

What is the maximum recommended fill volume per 16 mm tube?
For optimal evaporation efficiency and minimal splashing, maintain liquid levels at ≤75% of tube height. Typical working volume is 1–5 mL depending on volatility and boiling point.

Does the device support programmable multi-step temperature ramps?
No. The HNDK200-1 features single-setpoint temperature control only. Multi-stage protocols require manual intervention or external process controllers.

Are replacement modules available for purchase separately?
Yes. All NDK200-series interchangeable blocks—including 6 mm, 10 mm, 96-well, and custom configurations—are available as spare parts with documented dimensional and thermal specifications.