Hebei Jihepu ZLGJ-12 Standard Benchtop Freeze Dryer

Overview

The Hebei Jihepu ZLGJ-12 Standard Benchtop Freeze Dryer is an integrated, air-cooled lyophilization system engineered for pilot-scale laboratory applications requiring reliable, repeatable freeze-drying performance under controlled vacuum and low-temperature conditions. Based on the fundamental principles of sublimation—where ice transitions directly from solid to vapor phase under reduced pressure—the ZLGJ-12 facilitates gentle dehydration of thermolabile biologicals, pharmaceuticals, and research samples without compromising structural integrity or bioactivity. Its compact monolithic architecture eliminates external piping and potential leakage points, making it suitable for installation in standard laboratory spaces with limited floor area. Designed for GLP-compliant workflows, all product-contact surfaces—including stainless steel condenser chamber and drying shelf—are constructed from passivated 304 stainless steel to ensure corrosion resistance, ease of cleaning, and material inertness. The system operates within a validated environmental envelope (10–30 °C ambient, ≤70% RH) and meets electrical safety requirements per IEC 61010-1 for laboratory equipment.

Key Features

• Monolithic benchtop design with sealed refrigeration loop—no external coolant lines or refrigerant leaks.
• Stainless steel condenser chamber with large-diameter opening and no internal coil obstructions, enabling rapid pre-freezing of samples directly on the shelf—eliminating dependency on ultra-low temperature freezers.
• Patented gas flow distribution technology ensures uniform ice deposition across the condenser surface, maximizing capture efficiency and extending operational cycle stability.
• High-efficiency hermetic scroll compressor (international brand) delivers consistent cooling performance at ≤−80 °C (empty), with low acoustic emission (<62 dB[A]) and extended service life.
• Dual-stage rotary vane vacuum pump (certified brand) achieves ≤5 Pa ultimate vacuum with 2 L/s nominal pumping speed; integrated vacuum pump protection logic delays pump activation until condenser reaches safe operating temperature (e.g., <−40 °C), preventing oil backstreaming and moisture ingress.
• 7-inch full-color industrial touchscreen interface powered by SH-HPSC-II modular controller—supports PID-based shelf temperature control, real-time parameter monitoring, and programmable multi-step drying protocols.
• Embedded data logging system records time-stamped curves for condenser temperature, chamber pressure, and optional shelf/sensor temperatures; exportable as CSV files for post-processing in Excel or LIMS-compatible platforms.
• User-level access control with password-protected administrator/operator modes enables role-based operation and audit-ready accountability.
• Onboard sensor calibration utility allows field verification and adjustment of temperature and pressure transducers—supporting long-term measurement traceability and regulatory alignment with ISO/IEC 17025 practices.

Sample Compatibility & Compliance

The ZLGJ-12 accommodates diverse sample formats including bulk solutions in stainless steel trays (4 × φ200 mm, 70 mm vertical spacing), standard serum vials, and pharmaceutical-grade glass vials (e.g., 920 × φ12 mm, 480 × φ16 mm, or 260 × φ22 mm per batch). Its 0.12 m² drying area and 3–4 kg/24 h water removal capacity support early-phase formulation development, analytical reference standard preparation, and small-batch biopreservation. All wetted materials comply with USP Class VI and ISO 10993-5 cytotoxicity requirements. While not certified to FDA 21 CFR Part 11 out-of-the-box, the system’s audit trail functionality (timestamped user actions, parameter changes, and alarm events) provides foundational infrastructure for GMP/GLP validation when paired with qualified electronic signature procedures and secure network configuration.

Software & Data Management

Data acquisition and process supervision are managed via the embedded SH-HPSC-II controller firmware, which supports up to 32 programmable drying stages with independent setpoints for shelf temperature, chamber pressure, and hold duration. Real-time trend visualization includes dual-axis plots for condenser temperature vs. time and vacuum level vs. time, with adjustable scaling and overlay capability. Logged datasets include metadata such as operator ID, protocol name, start/stop timestamps, and system status flags (e.g., “condenser overload”, “vacuum leak detected”). Export is restricted to USB storage devices in plain-text CSV format—ensuring compatibility with third-party statistical analysis tools and laboratory information management systems (LIMS). No cloud connectivity or remote access capabilities are implemented, preserving data sovereignty and minimizing cybersecurity exposure.

Applications

• Lyophilization of monoclonal antibodies, vaccines, and enzyme preparations in R&D and quality control laboratories.
• Stabilization of microbial cultures, probiotics, and diagnostic reagents for long-term storage.
• Preparation of reference standards for HPLC, mass spectrometry, and dissolution testing.
• Drying of botanical extracts, food matrices, and forensic evidence where volatile compound retention is critical.
• Process development and parameter optimization prior to scale-up on production-grade freeze dryers.

FAQ

What is the maximum batch volume supported by the ZLGJ-12?
The unit supports up to 4 × φ200 mm stainless steel trays (total area 0.12 m²) or up to 920 × 12 mm serum vials per cycle—equivalent to approximately 2–3 L of aqueous solution depending on fill depth and collapse temperature.

Can the system operate continuously for extended periods?
Yes—designed for unattended overnight operation, with automatic defrost triggered after each cycle via natural ambient-air thawing; total downtime between cycles is typically 60–90 minutes depending on ambient temperature and ice load.

Is external cooling water required?
No—the ZLGJ-12 uses air-cooled condensation; only standard 220 V/50 Hz power and adequate ventilation (≥30 cm clearance around rear and sides) are necessary.

Does the controller support custom protocol creation and recall?
Yes—up to 16 user-defined drying programs can be stored locally, each with configurable ramp rates, dwell times, and pressure modulation steps.

What maintenance intervals are recommended?
Vacuum pump oil replacement every 500 operating hours; condenser cleaning after every 10–15 cycles; annual verification of temperature and pressure sensor accuracy using NIST-traceable references.