Hexion H/T18MM High-Speed Benchtop Centrifuge

Overview

The Hexion H/T18MM is a high-performance benchtop refrigerated centrifuge engineered for precision separation in life science, clinical diagnostics, and pharmaceutical research laboratories. Operating on the principle of sedimentation under controlled centrifugal force, it delivers reproducible pelleting, layering, and clarification of biological suspensions—including mammalian cells, subcellular organelles, nucleic acids, and viral particles—within defined thermal and mechanical parameters. With a maximum rotational speed of 18,500 rpm and an RCF of 24,640 × g, the system supports high-resolution differential centrifugation protocols while maintaining sample integrity across temperature-sensitive workflows. Its integrated refrigeration module ensures stable operation between –20 °C and +40 °C, critical for preserving enzyme activity, preventing protein denaturation, and minimizing thermal drift during extended runs.

Key Features

• Brushless DC motor drive with high-torque output and microprocessor-based closed-loop speed control, enabling ±50 rpm speed accuracy and low-vibration performance (≤60 dB[A])
• TFT-LCD true-color touchscreen interface with bilingual (English/Chinese) and multilingual menu support (including Russian and Portuguese), dual-input mode (touch + physical keys), and real-time display of setpoints vs. actual values
• 10-step programmable acceleration/deceleration profiles to optimize pelleting integrity and minimize resuspension—especially vital for fragile pellets such as lymphocytes or exosomes
• Airtight fixed-angle rotors featuring RoHS-compliant silicone elastomer gaskets (EU Directive 2015/863), validated to contain aerosols during high-speed operation and meet biosafety level 2 (BSL-2) containment requirements
• Triple-damping mechanical suspension system combined with a reinforced 304 stainless steel centrifuge chamber and triple-layer steel protective housing for structural stability and operator safety
• Auto-sensing motorized door lock mechanism requiring only gentle lid closure; integrated safety interlock prevents operation unless fully sealed and balanced
• 20 user-programmable protocol slots with automatic recall of last-used method at power-on

Sample Compatibility & Compliance

The H/T18MM accommodates a broad range of primary and secondary sample containers via interchangeable rotors and adapters. Standard configurations include a 6 × 50 mL fixed-angle rotor (most widely deployed in routine serum/plasma processing), alongside optional aviation-grade aluminum rotors compatible with tubes from 0.2 mL PCR strips to 100 mL conical centrifuge bottles. It also supports microtiter plates (MTPs), PCR plates, and cell culture plates using dedicated carriers. All rotors are dynamically balanced and certified for continuous operation at rated speeds. The device holds CFDA registration as a Class II medical device and complies with ISO 9001:2015 (quality management) and ISO 13485:2016 (medical device quality systems). While not FDA 510(k)-cleared, its design aligns with general principles outlined in CLSI EP05-A3 and ISO 20943 for centrifuge performance verification.

Software & Data Management

The embedded firmware supports audit-ready operation through timestamped parameter logging, including run start/end time, speed, RCF, temperature, acceleration profile, and fault event records. Though no external PC connectivity or cloud synchronization is built-in, all data remain accessible via on-device history review and can be exported manually via USB interface (optional accessory). The system adheres to GLP-aligned practices by retaining full traceability of user-defined programs and operational states. Firmware updates are performed locally via secure USB media, ensuring version control without network exposure. No proprietary software suite is required—basic calibration, validation, and maintenance procedures follow documented internal routines compliant with ISO/IEC 17025 clause 6.4.3 for equipment verification.

Applications

• Differential centrifugation of whole blood to isolate platelet-rich plasma (PRP), buffy coat, and erythrocyte fractions
• Purification of extracellular vesicles (exosomes) from cell culture supernatants or biofluids using sequential ultracentrifugation-compatible protocols
• Nucleic acid precipitation and recovery following phenol-chloroform extraction or ethanol precipitation steps
• Clarification of bacterial lysates prior to chromatographic purification or SDS-PAGE analysis
• Concentration of low-abundance proteins or antibodies from dilute solutions in immunoassay development
• Routine QC testing of vaccine formulations involving adjuvant particle size distribution assessment

FAQ

Is the H/T18MM suitable for GMP-regulated environments?
Yes—it meets ISO 13485:2016 requirements for medical device manufacturing and includes features essential for regulated workflows, including programmable method recall, parameter logging, and mechanical safety redundancies. However, formal 21 CFR Part 11 compliance requires supplemental procedural controls, as the unit lacks electronic signature capability.
Can I use this centrifuge for virus purification?
It supports initial concentration and crude fractionation steps commonly used in viral vector workflows, but does not replace ultracentrifuges (>100,000 × g) required for density gradient purification of intact virions.
What rotor certifications are provided?
Each rotor carries individual serial-numbered certification confirming dynamic balance, material traceability (Al 6061-T6 or equivalent), and fatigue-tested service life per ISO 15527 Annex B guidelines.
Does the unit support remote monitoring or network integration?
No native Ethernet or Wi-Fi interface is included; all operation and diagnostics occur locally via the onboard interface.
How often does the refrigeration system require servicing?
Under standard laboratory conditions (25 °C ambient, 50% RH), the sealed R134a-based cooling circuit is maintenance-free for ≥5 years; annual verification of temperature uniformity and compressor efficiency is recommended per ISO/IEC 17025.