INNOTEG EasyPrep MP Medium-Pressure Preparative Chromatography System (Automated Flash Chromatography Workstation)

Overview

The INNOTEG EasyPrep MP is a fully integrated medium-pressure preparative chromatography system engineered for reliable, reproducible flash purification of organic compounds in research and development laboratories. Based on classical liquid chromatography principles—utilizing solvent gradient elution, UV absorbance detection, and fraction-triggered collection—the system delivers robust performance across diverse compound classes including pharmaceutical intermediates, natural products, synthetic polymers, and bioactive small molecules. Designed for operational simplicity without compromising analytical rigor, the EasyPrep MP combines a high-precision dual- or quad-solvent delivery module, a fixed-wavelength UV-Vis detector, real-time pressure monitoring, and an intelligent fraction collector—all coordinated via an embedded 12.1-inch capacitive touchscreen interface. Its architecture conforms to fundamental chromatographic best practices: laminar flow dynamics, minimized dwell volume, low-dead-volume fluidic pathways, and chemically resistant wetted materials (e.g., PEEK, stainless steel, sapphire optics), ensuring compatibility with common organic solvents (hexane, ethyl acetate, methanol, acetonitrile, DCM, and aqueous buffers).

Key Features

• Modular solvent delivery: configurable for binary (MP200) or quaternary (MP400) gradient operation with integrated solvent level sensors and automatic leak detection
• UV-Vis detection at selectable wavelengths between 200–400 nm; optimized optical path for stable baseline performance (baseline noise ≤ 1 × 10⁻⁴ AU at 254 nm with water)
• High-accuracy peristaltic or piston-driven metering pump delivering flow rates from 1 to 200 mL/min with ≤ ±2% accuracy across full range
• Real-time pressure monitoring up to 200 psi with programmable overpressure cutoff and audible/visual alerts
• Intelligent fraction collection supporting multiple modes: full-collection, peak-based (threshold- or derivative-triggered), time-based, and user-defined volume-based collection
• Automated column drying function enabling nitrogen purge post-run to extend column lifetime and prevent solvent residue buildup
• Touchscreen workstation with intuitive method editor: drag-and-drop gradient programming, live flow rate adjustment, on-the-fly gradient modification, and one-click system priming/cleaning protocols
• Integrated hardware safety suite: tube rack presence detection, waste bottle level sensing, solvent reservoir monitoring, and leak detection via drip tray sensors

Sample Compatibility & Compliance

The EasyPrep MP accommodates standard commercial flash cartridges from 4 g to 800 g (both normal-phase silica and reversed-phase C18/C8 media), supporting scalable purification from milligram to multi-gram quantities. Its fluidic design minimizes band broadening and ensures consistent resolution across load ranges. While not certified for GMP production environments, the system supports GLP-aligned workflows through audit-trail-capable method storage, timestamped run logs, PDF report generation (including chromatograms, collection maps, and system parameters), and user-accessible calibration records. It meets general laboratory safety standards per IEC 61010-1 and complies with electromagnetic compatibility requirements (EN 61326-1). All electronic modules are CE-marked and RoHS-compliant.

Software & Data Management

The embedded control software provides a dedicated chromatography environment with no external PC dependency. Methods—including gradient profiles, flow programs, detection settings, and collection logic—are stored locally with versioned backups. Each run generates a structured data package containing raw absorbance traces, pressure curves, collection event timestamps, and tube-to-peak mapping metadata. Batch reporting exports chromatograms, retention times, fraction volumes, and summary statistics as searchable PDFs compliant with internal documentation standards. Data export options include CSV for third-party analysis tools (e.g., Excel, Origin, Chromeleon). System diagnostics, maintenance logs, and error history are accessible via administrator mode for traceability during method validation or internal audits.

Applications

The EasyPrep MP serves as a core purification platform in academic and industrial R&D labs engaged in synthetic organic chemistry, medicinal chemistry, natural product isolation, process optimization, and impurity profiling. Typical use cases include: rapid parallel purification of reaction mixtures following Suzuki or Buchwald–Hartwig couplings; isolation of diastereomers from chiral syntheses; desalting and buffer exchange of peptide fractions; removal of catalyst residues from transition-metal-catalyzed reactions; and preparative separation of plant extracts for bioactivity screening. Its flexibility in column sizing and gradient control makes it suitable for both exploratory scouting runs and reproducible scale-up studies within the same instrument footprint.

FAQ

What column formats and sizes are supported?
The system accepts standard commercial flash columns ranging from 4 g to 800 g, including both normal-phase (silica gel) and reversed-phase (C18, C8) cartridges. Column adapters accommodate common diameters (10–60 mm) and lengths (50–200 mm).
Is method transfer possible between different EasyPrep MP units?
Yes—methods are saved in a portable binary format compatible across all EasyPrep MP instruments (MP200 and MP400 models). Gradient profiles, collection rules, and instrument parameters retain fidelity when imported onto another unit.
Does the system support 21 CFR Part 11 compliance?
The base configuration does not include electronic signature or role-based access controls required for full FDA 21 CFR Part 11 compliance; however, audit-trail functionality and immutable run logs provide foundational elements for internal validation under GLP or ISO 17025 frameworks.
Can I integrate the EasyPrep MP with my existing LIMS or ELN?
Direct API integration is not available; however, exported PDF reports and CSV data files can be manually ingested into most ELN platforms (e.g., LabArchives, Benchling) or LIMS systems via standard import modules.
What maintenance is required for long-term reliability?
Recommended routine maintenance includes quarterly pump seal inspection, annual UV lamp replacement, biannual solvent filter replacement, and regular verification of flow accuracy and pressure sensor calibration using certified reference standards.