INNYAO OAR-30 / OAR-100 / OAR-300 Continuous Multi-Stage Stirred Reactor
| Brand | INNYAO |
|---|---|
| Model Series | OAR-30, OAR-100, OAR-300 |
| Temperature Range | 10–180 °C |
| Reaction Volume | 100 mL (per stage) |
| Origin | Zhejiang, China |
| Supplier Type | Authorized Distributor |
| Compliance | Designed for laboratory-scale continuous flow synthesis and kinetic studies |
Overview
The INNYAO OAR-Series Continuous Multi-Stage Stirred Reactor is an engineered platform for controlled, scalable chemical synthesis under steady-state or transient conditions. Unlike batch reactors, the OAR system implements a cascade of independently temperature-regulated, mechanically agitated reaction zones—each functioning as a well-mixed CSTR (Continuous Stirred-Tank Reactor)—to emulate plug-flow behavior with enhanced residence time distribution control. This architecture enables precise investigation of reaction kinetics, intermediate accumulation, catalyst deactivation profiles, and heat/mass transfer limitations across sequential transformation steps. The system is particularly suited for optimizing multi-step organic syntheses, heterogeneous catalysis, polymerization initiation/propagation sequences, and pharmaceutical route scouting where reproducible staging of reagent addition, pH shift, or thermal activation is critical.
Key Features
- Modular multi-stage configuration: Available in 3-, 5-, and 7-reactor variants (OAR-30, OAR-100, OAR-300 denote nominal total volume capacity in mL; individual stage volume is 100 mL)
- Independent PID-controlled heating for each stage (range: 10–180 °C), with ±0.3 °C thermal stability and <2 °C inter-stage uniformity
- Variable-speed overhead stirring (0–600 rpm) per stage, equipped with PTFE-coated dual-blade impellers for low-shear mixing and gas dispersion capability
- Integrated peristaltic feed pumps with flow rate accuracy ±1.5% FS for continuous reagent introduction and inter-stage transfer
- Corrosion-resistant wetted materials: Borosilicate glass vessels, PTFE seals, Hastelloy C-276 inlet/outlet fittings, and chemically inert tubing pathways
- Front-panel touchscreen HMI with real-time monitoring of temperature, stir speed, flow rate, and pressure differentials across stages
Sample Compatibility & Compliance
The OAR-Series accommodates a broad range of liquid-phase and slurry-based reaction systems—including aqueous, organic, and biphasic media—with compatibility verified for common solvents (e.g., THF, DMF, EtOH, toluene, water) and moderate concentrations of acids, bases, and metal catalysts. Each reactor stage features a standard 14/20 or 24/29 ground-glass joint interface, enabling direct integration with condensers, gas inlets (N₂, H₂, O₂), sampling ports, and inline IR/UV-Vis flow cells. The system supports GLP-compliant operation through configurable audit trails, user-level access control (admin/operator modes), and timestamped parameter logging. While not certified to UL/CE for standalone industrial deployment, it meets IEC 61010-1 safety requirements for laboratory electrical equipment and is routinely deployed in R&D labs adhering to ISO/IEC 17025 and ASTM E2500-17 guidelines for equipment qualification.
Software & Data Management
The OAR controller runs embedded Linux firmware with optional PC-based INNYAO SynthControl™ software (Windows/macOS). This application provides synchronized acquisition of up to 16 analog/digital process variables per experiment, including temperature gradients, stir torque (via current sensing), flow pulse counts, and external sensor inputs (e.g., pH, conductivity, dissolved oxygen). All data are saved in HDF5 format with embedded metadata (user ID, method file hash, calibration timestamps), ensuring traceability per FDA 21 CFR Part 11 requirements when configured with digital signature and electronic record retention policies. Export options include CSV, MATLAB .mat, and PDF report generation with customizable templates aligned to internal SOPs.
Applications
- Kinetic modeling of consecutive reactions (e.g., A→B→C) via residence time variation and stage-wise concentration profiling
- Screening of supported catalyst performance across multiple temperature zones under continuous H₂ or CO feed
- Controlled crystallization of APIs using staged supersaturation modulation and anti-solvent addition
- Enzymatic cascade reactions requiring compartmentalized pH or cofactor management
- Photochemical synthesis with integrated LED arrays (optional add-on) for wavelength-selective irradiation per stage
- Scale-down validation of pilot-plant continuous processes prior to GMP manufacturing transfer
FAQ
What is the maximum operating pressure for the OAR-Series reactors?
Standard configurations operate at ambient pressure; optional pressure-rated glass vessels (up to 5 bar g) and magnetic coupling stirrers are available upon request.
Can the OAR system be integrated with third-party analytical instruments?
Yes—RS-485 Modbus RTU and Ethernet TCP/IP interfaces support bidirectional communication with HPLC autosamplers, FTIR spectrometers, and mass spectrometers for automated feedback control loops.
Is validation documentation provided for IQ/OQ protocols?
INNYAO supplies a comprehensive User Requirement Specification (URS) template, Factory Acceptance Test (FAT) report, and calibration certificates for all sensors; site-specific Installation and Operational Qualification support is available through authorized service partners.
How is cleaning and cross-contamination prevention addressed between experiments?
Each stage includes dedicated solvent rinse cycles programmable via the HMI; glass components are autoclavable, and the modular design allows rapid disassembly and replacement of wetted parts without recalibration.
