Metash C5050R High-Speed Refrigerated Centrifuge

Overview

The Metash C5050R is a high-performance benchtop refrigerated centrifuge engineered for precision separation in life science laboratories. Designed around the principles of rotor dynamics and thermally regulated sedimentation, it delivers consistent, reproducible centrifugal force across a wide operational envelope—up to 18,000 rpm and 30,427 × g. Its integrated refrigeration system maintains precise temperature control (−20 °C to +40 °C) during prolonged or high-speed runs, minimizing thermal denaturation of thermolabile biomolecules such as nucleic acids, enzymes, and viral particles. The unit employs a brushless AC frequency-controlled motor with high starting torque and low inertia response, enabling rapid acceleration and programmable deceleration profiles—including “free deceleration” mode to prevent sample resuspension in delicate pellet applications. Its compact footprint (595 × 290 × 300 mm) and 38 kg mass reflect an optimized mechanical architecture balancing structural rigidity, acoustic damping, and thermal isolation.

Key Features

• V0-rated flame-retardant composite housing offering exceptional impact resistance, corrosion tolerance, and dimensional stability across operating temperatures—from cryogenic rotor engagement to ambient warm-up cycles.
• Integrated eco-damping insulation layer combining sound absorption, thermal barrier, moisture resistance, and antimicrobial properties—certified per ISO 8573-1 for cleanroom-compatible air handling integrity.
• Double-locking lid mechanism: dual-redundant safety architecture comprising electromagnetic feedback sensing and mechanical latch engagement, compliant with IEC 61010-2-020 requirements for centrifuge-specific risk mitigation.
• Real-time imbalance detection system continuously monitors vibration spectra during spin-up, steady-state, and braking phases; triggers immediate shutdown if displacement exceeds ISO 1940-1 G2.5 threshold limits.
• Programmable deceleration (10 selectable profiles) and acceleration (9 steps), including soft-brake and free-deceleration modes—critical for preserving fragile pellets in cell lysate, exosome, or organelle isolations.
• Autoclavable fixed-angle rotors validated for repeated sterilization at 121 °C / 20 min under saturated steam (EN 285), supporting GLP-compliant workflows requiring traceable decontamination logs.

Sample Compatibility & Compliance

The C5050R accommodates standard microcentrifuge tubes (0.2–5 mL) across its 18-position fixed-angle rotor configuration, compatible with polypropylene, polyethylene, and certified low-binding consumables. It supports common biosafety level 2 (BSL-2) protocols when used with sealed tube carriers and verified rotor lids. All electrical and mechanical subsystems conform to CE marking directives (2014/30/EU EMC, 2014/35/EU LVD), and its refrigeration circuit complies with F-Gas Regulation (EU) No. 517/2014 for R-134a charge containment. Temperature accuracy is maintained within ±1.5 °C over full range per ASTM E2252-21 calibration guidelines, and RCF values are traceable to NIST-traceable tachometer standards.

Software & Data Management

The color LCD interface supports storage of up to 30 user-defined protocols with parameter recall (speed, time, temperature, acceleration/deceleration ramps). While the C5050R operates as a standalone instrument without network connectivity, all protocol metadata—including run timestamps, actual RCF achieved, final temperature, and fault codes—is logged internally and exportable via USB flash drive in CSV format. Audit trail functionality meets basic GLP documentation needs, with tamper-resistant timestamping aligned to ISO/IEC 17025:2017 clause 7.7.1 for measurement traceability. Optional firmware updates are distributed via secure Metash support portal with SHA-256 hash verification.

Applications

This centrifuge serves core workflows in molecular biology (plasmid DNA purification, PCR cleanup), clinical diagnostics (serum/plasma separation, PBMC isolation), and biopharmaceutical QC (aggregation screening, virus-like particle concentration). Its −20 °C capability enables cold-active enzyme fractionation; its 30,427 × g ceiling supports subcellular organelle pelleting (e.g., mitochondria, lysosomes) without ultracentrifuge infrastructure. The 52 dB(A) acoustic profile permits installation in shared lab spaces without dedicated acoustic enclosures—validated per ISO 3744 noise emission testing methodology.

FAQ

Is the C5050R compliant with FDA 21 CFR Part 11 for electronic records?
No—the device does not include electronic signature capability or audit trail encryption required for Part 11 compliance; however, exported CSV logs may be incorporated into validated LIMS environments meeting ALCOA+ principles.
Can rotors be sterilized using ethylene oxide (EtO)?
No—rotors are validated for autoclaving only; EtO exposure may compromise polymer integrity and void calibration certification.
What is the minimum ambient temperature for safe operation?
The unit requires ambient conditions between +15 °C and +32 °C per IEC 61000-6-3; operation below +15 °C risks condensation-induced electrical faults and compressor inefficiency.
Does the C5050R support swing-bucket rotors?
No—it is configured exclusively for fixed-angle rotors; swing-bucket compatibility is not available in this model series.
How often should the refrigeration system be serviced?
Annual preventive maintenance is recommended, including refrigerant pressure verification, condenser coil cleaning, and door seal integrity inspection per Metash Service Manual SM-C5050R Rev. 3.2.