METTLER TOLEDO XPR225DUE/AC Advanced Analytical Balance

Overview

The METTLER TOLEDO XPR225DUE/AC is a high-precision analytical balance engineered for laboratories requiring rigorous mass measurement performance under regulated and non-regulated environments. Operating on electromagnetic force compensation (EMFC) principle, it delivers stable, drift-free weighing results with dual-range capability—220 g at 0.1 mg readability and 121 g at ultra-fine 0.01 mg resolution—enabling seamless transition between routine QC checks and critical method development tasks. Its compact yet robust architecture integrates advanced environmental compensation algorithms to mitigate thermal drift and air current effects, ensuring reproducibility across variable lab conditions. Designed as part of the XPR Essential series, the XPR225DUE/AC meets the core metrological requirements of ISO/IEC 17025-accredited testing labs while maintaining full alignment with pharmacopeial standards including USP and EP 2.1.1.

Key Features

• Dual-range weighing mode: 220 g @ 0.1 mg and 121 g @ 0.01 mg—optimized for flexibility in method validation and sample screening.
• Automatic internal calibration with FACT (Fully Automatic Calibration Technology), triggered by temperature change (>1.5 °C) or time interval—ensuring continuous traceability without manual intervention.
• 7-inch full-color TFT capacitive touchscreen with intuitive icon-driven interface, supporting multi-touch gestures and customizable home screens.
• Comprehensive user management system: unlimited user accounts, role-based permission levels (e.g., operator, supervisor, administrator), and mandatory password authentication.
• Integrated connectivity suite: native USB-A (for printers/storage), USB-B (for PC/LabX integration), Ethernet (for networked data transfer), plus optional RS232 and Bluetooth modules.
• Compact footprint (195 mm wide × 456 mm deep) with ergonomic pan geometry (78 mm × 73 mm) designed for optimal sample placement and draft shield compatibility.

Sample Compatibility & Compliance

The XPR225DUE/AC supports standard analytical workflows involving solids, powders, liquids, and small-volume containers—including volumetric flasks, vials, and crucibles—within its specified pan dimensions and height clearance. It is fully compatible with METTLER TOLEDO’s GWP® (Good Weighing Practice) verification framework and satisfies minimum weight criteria per USP (20 mg at 0.1% tolerance, 2 mg at 1% uncertainty). While it does not include active electrostatic detection hardware, its grounded weighing cell design and optional anti-static accessories (e.g., ionizing bars, conductive mats) support compliance in low-humidity environments. The balance is certified to OIML R 76-1 (Class I) and conforms to regulatory expectations for audit-ready documentation under GLP, GMP, and FDA 21 CFR Part 11 when used with LabX software.

Software & Data Management

Data integrity and process control are enforced through seamless integration with METTLER TOLEDO LabX laboratory software. LabX provides electronic signatures, full audit trail (including user actions, parameter changes, and calibration events), and automated report generation compliant with 21 CFR Part 11 Annex 11 requirements. All weighing data—including timestamps, metadata (operator ID, method name, location), and raw sensor output—is stored centrally and exportable in CSV, PDF, or XML formats. Local device logging retains up to 10,000 records with timestamped entries, enabling offline traceability during network outages. Customizable SOP-driven workflows can be deployed directly to the balance interface, reducing transcription errors and enforcing procedural consistency across shifts.

Applications

• Pharmaceutical QC/QA: Active pharmaceutical ingredient (API) assay, reference standard preparation, content uniformity testing, and dissolution sample weighing.
• Chemical R&D: Catalyst dosage, stoichiometric reagent dispensing, and gravimetric titration standardization.
• Food & Beverage: Nutrient labeling compliance (e.g., vitamin fortification), moisture loss determination, and batch release testing.
• Academic & Contract Research: Method validation studies requiring documented repeatability, intermediate precision, and uncertainty budgets.
• Regulatory Audits: Pre-configured GWP® reports, calibration history logs, and electronic signature workflows satisfy inspection readiness requirements.

FAQ

Is the XPR225DUE/AC compliant with USP for minimum weight determination?
Yes—the balance meets USP criteria for both typical (20 mg at 0.1% tolerance) and statistical (2 mg at U = 1%, k = 2) minimum weight thresholds.
Does it support 21 CFR Part 11 compliance out of the box?
Hardware-level compliance requires LabX software deployment; the balance provides all necessary controls (user authentication, audit trail logging, electronic signatures) when integrated with LabX.
Can the internal calibration be scheduled manually or only via FACT triggers?
Manual calibration initiation is available via the touchscreen menu; FACT remains active as an autonomous safeguard but does not override operator-initiated calibrations.
What draft shields are compatible with this model?
It is designed for use with METTLER TOLEDO’s universal GWP-compatible draft shields (e.g., XS-FS, XS-PS series), which mount directly without tools and maintain full touchscreen accessibility.
Is Ethernet connectivity enabled by default or requires configuration?
Ethernet port is physically present and enabled upon first boot; IP assignment supports DHCP or static configuration via LabX or local setup wizard.