METTLER TOLEDO XPR26/56 Micro Analytical Balance

Overview

The METTLER TOLEDO XPR26/56 is a high-precision micro analytical balance engineered for laboratories requiring trace-level mass measurement with uncompromising accuracy, stability, and regulatory compliance. Based on electromagnetic force compensation (EMFC) technology, it delivers metrological performance optimized for critical applications in pharmaceutical quality control, reference standard preparation, catalyst dosing, and nanomaterial characterization. Its dual-range configuration (22 g / 5.1 g and 52 g / 11 g variants) supports both ultra-low-mass weighing (down to 1.4 mg minimum weight per USP ) and extended capacity operations without sacrificing resolution. The balance integrates advanced environmental compensation—including Active Temperature Control (ATC™) and real-time air buoyancy correction—to mitigate thermal drift and convective disturbances, ensuring consistent repeatability (<0.0003 mg at 5% load) across variable lab conditions.

Key Features

• Electromagnetic force compensation (EMFC) sensor architecture with zero-point stability <0.0001 mg/30 min and linearity error <±0.0005 mg over full range
• proFACT automatic internal calibration system—triggered by time intervals or temperature deviations ≥1.0 °C—performing full internal weight verification including linearity adjustment
• Active Temperature Control (ATC™) maintains constant sensor housing temperature within ±0.1 °C, reducing thermal influence on measurement stability
• SmartSens infrared motion detection enables hands-free tare, print, and data transfer—minimizing mechanical perturbation and contamination risk
• StatusLight™ tri-color LED indicator (red/yellow/green) provides immediate visual feedback on operational readiness, leveling status, and environmental suitability
• MinWeigh™ dynamic warning function—configurable via service engineer—monitors sample mass in real time and alerts when below USP-defined minimum weight thresholds (e.g., 1.4 mg at k=2, U=0.10%)
• Patented draft shield with integrated side-loading window allows direct sample introduction into tared vessels without opening doors—reducing stabilization time to ≤2.5 s
• Capacitive color touchscreen (7″, 1280×800 px) with intuitive icon-based navigation, multi-language support (including English, German, French, Chinese), and contextual help overlays

Sample Compatibility & Compliance

The XPR26/56 accommodates diverse sample formats—from microgram-scale powders and crystalline APIs to volatile solvents and hygroscopic compounds—within its low-profile, ergonomic draft shield. Its design conforms to United States Pharmacopeia (USP) Chapters (Balances) and (Minimum Weight Determination), supporting GxP-aligned workflows. Full audit trail functionality complies with FDA 21 CFR Part 11 requirements when paired with METTLER TOLEDO LabX® software, enabling electronic signatures, user-level permission hierarchies (admin/operator/technician), and immutable change history logging. Built-in GWP® Verification ensures ongoing fitness-for-purpose through automated performance checks aligned with ISO/IEC 17025 and ICH Q7 guidelines.

Software & Data Management

Data integrity is enforced via native USB-A (4 ports) and Ethernet (1× 10/100BASE-TX) connectivity. All measurements export in CSV, XML, or PDF format with embedded metadata (timestamp, operator ID, environment log, calibration status). When integrated with LabX®, the balance supports centralized method management, SOP-driven weighing protocols, automated report generation, and seamless LIMS/ERP synchronization. Electronic signature workflows, role-based access control, and encrypted database storage meet ALCOA+ principles (Attributable, Legible, Contemporaneous, Original, Accurate, Complete, Consistent, Enduring, Available).

Applications

• Pharmaceutical QC: USP-compliant assay of reference standards, impurity quantification, and content uniformity testing
• Materials science: Precise formulation of catalysts, battery electrode slurries, and nanocomposite precursors
• Academic research: Gravimetric preparation of calibration standards for ICP-MS, HPLC, and titration
• Environmental labs: Weighing of filter media pre/post-extraction for PM2.5 and heavy metal analysis
• Forensics: Trace evidence handling with chain-of-custody documentation and tamper-proof audit trails

FAQ

What is the minimum weighable mass according to USP ?
For the XPR26/56 (52 g / 11 g version), the minimum weight is 2.0 mg at k=2 and U=0.10%, verified under controlled environmental conditions.
Does the balance support GLP/GMP-compliant data archiving?
Yes—when used with LabX® software, it generates fully compliant audit trails, electronic signatures, and secure database backups meeting 21 CFR Part 11 and Annex 11 requirements.
How often does proFACT initiate calibration?
Calibration triggers automatically upon user-defined time intervals (e.g., every 2–24 hours) or temperature shifts ≥1.0 °C—both parameters configurable via touchscreen or LabX®.
Can the MinWeigh™ function be enabled post-installation?
Yes—activation requires on-site configuration by an authorized METTLER TOLEDO service engineer to validate environmental stability and performance baseline.
Is external vibration isolation required?
While not mandatory, operation on a granite slab or active vibration-damping table is recommended for optimal repeatability in environments with >0.5 µm/s RMS floor vibration.