METTLER TOLEDO XPR304E/AC Analytical Balance

Overview

The METTLER TOLEDO XPR304E/AC is a high-performance analytical balance engineered for precision mass measurement in regulated laboratory environments. Designed according to the principles of electromagnetic force compensation (EMFC), it delivers stable, drift-free weighing results with exceptional reproducibility and long-term stability. Its core architecture integrates an advanced monolithic sensor platform, temperature-compensated electronics, and a robust draft shield system—ensuring reliable operation under variable ambient conditions typical of QC labs, R&D facilities, and production support environments. With a maximum capacity of 320 g and certified readability of 0.1 mg (traceable to national standards), the XPR304E/AC meets the stringent requirements of pharmacopeial methods including USP for accuracy and repeatability. Its compact footprint and ergonomic 7-inch color TFT touchscreen interface facilitate seamless integration into benchtop workflows across pharmaceutical, chemical, food & beverage, and academic laboratories.

Key Features

• Electromagnetic force compensation (EMFC) transducer technology for high linearity and minimal hysteresis
• FACT (Fully Automatic Calibration Technology) with internal motorized weights—enabling temperature-triggered and time-scheduled recalibration without manual intervention
• Intelligent stabilization algorithm achieving consistent 1.5 s settling time across full range, independent of sample loading dynamics
• 7-inch capacitive touchscreen with intuitive icon-based navigation, multi-language support, and customizable home screen layouts
• Comprehensive user management system supporting unlimited accounts with role-based permissions (e.g., operator, supervisor, administrator)
• Integrated static detection warning system (optional accessory-dependent) to alert users when electrostatic interference exceeds threshold limits
• Rugged aluminum alloy housing with chemically resistant surface coating, optimized for cleanroom-compatible cleaning protocols

Sample Compatibility & Compliance

The XPR304E/AC accommodates standard analytical sample containers—including weighing boats, vials, crucibles, and filter papers—within its 78 mm × 73 mm stainless steel pan area. Its draft shield design complies with ISO 9001 and ISO/IEC 17025 environmental control guidelines, minimizing air current-induced uncertainty. The balance satisfies critical regulatory thresholds defined in USP for minimum weight determination (82 mg at 0.1% tolerance), and supports audit-ready documentation via METTLER TOLEDO’s LabX software. It is validated for use in GxP environments requiring adherence to FDA 21 CFR Part 11 (electronic records and signatures), with full traceability of all calibration events, user actions, and result modifications—including timestamps, operator IDs, and reason-for-change fields.

Software & Data Management

When connected to LabX laboratory software (v3.10 or later), the XPR304E/AC enables centralized instrument control, automated report generation, and secure data archiving. LabX provides electronic signature workflows, customizable SOP-driven weighing procedures, and real-time deviation alerts during method execution. All raw data—including metadata such as environmental temperature, humidity, and leveling status—are embedded within PDF or Excel export files. Audit trails comply with ALCOA+ principles (Attributable, Legible, Contemporaneous, Original, Accurate, Complete, Consistent, Enduring, Available), ensuring readiness for regulatory inspections under ICH, EMA, or FDA guidance.

Applications

• Quantitative assay preparation in pharmaceutical development and QC release testing
• Standard solution preparation for HPLC, GC, and ICP-MS calibration workflows
• Moisture content analysis using gravimetric loss-on-drying protocols
• Formulation development requiring precise active pharmaceutical ingredient (API) dosing
• Raw material identity verification via differential weighing against reference standards
• Stability study sample handling under ICH Q1–Q5 conditions
• Food safety testing involving allergen quantification and nutrient labeling compliance

FAQ

What is the certified readability of the XPR304E/AC, and how is it verified?
The certified readability is 0.1 mg, verified through factory calibration against NIST-traceable mass standards and documented in the included Certificate of Conformance (CoC).
Does the balance meet USP requirements for minimum weight?
Yes—the typical minimum weight is 82 mg at 0.1% tolerance, determined per USP methodology using k = 2 and U = 1% uncertainty criteria.
Is external calibration required after FACT internal calibration?
No; FACT ensures metrological integrity between scheduled calibrations, though periodic external verification with certified weights is recommended per ISO/IEC 17025 quality management systems.
Can multiple users be assigned distinct access levels?
Yes—LabX-integrated user management allows assignment of granular permissions (e.g., calibration lockout, method editing rights, data deletion restrictions).
Which connectivity options support direct integration with LIMS or ERP systems?
Ethernet and USB-B interfaces enable native communication with LabX, which provides ODBC, REST API, and HL7 protocol support for enterprise system interoperability.